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REVERSE T3

REVERSE T3 Structure
REVERSE T3 structure
CAS No.
5817-39-0
Chemical Name:
REVERSE T3
Synonyms
T3;TRIIODOTHYRONINE;rT3;LIOTHYRONIN;Reverse triiodothyronine;(2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid;L-T3-13C6;REVERSE T3;3,3',5'-T3;linothyronine
CBNumber:
CB5221268
Molecular Formula:
C15H12I3NO4
Molecular Weight:
650.97
MDL Number:
MFCD00036864
MOL File:
5817-39-0.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-15 13:06:51
Product description Number Pack Size Price
3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant? T-075 1mL $144
3,3'',5''-Triiodo-L-thyronine ≥95% 17598 5mg $109
3,3'',5''-Triiodo-L-thyronine ≥95% 17598 10mg $207
3,3'',5''-Triiodo-L-thyronine ≥95% 17598 25mg $464
3,3'',5''-Triiodo-L-thyronine ≥95% 17598 50mg $818
More product size
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REVERSE T3 Properties

Melting point 234-238 °C(lit.)
Boiling point 534.6±50.0 °C(Predicted)
Density 2.387±0.06 g/cm3(Predicted)
Flash point 9℃
storage temp. Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility DMSO (Slightly), Methanol (Slightly)
form powder
pka 2.17±0.20(Predicted)
color Pale Beige to Brown
Stability Light Sensitive
Major Application clinical testing
clinical testing
InChI InChI=1S/C15H12I3NO4/c16-9-3-7(4-12(19)15(21)22)1-2-13(9)23-8-5-10(17)14(20)11(18)6-8/h1-3,5-6,12,20H,4,19H2,(H,21,22)/t12-/m0/s1
InChIKey HZCBWYNLGPIQRK-LBPRGKRZSA-N
SMILES C(O)(=O)[C@H](CC1=CC=C(OC2=CC(I)=C(O)C(I)=C2)C(I)=C1)N
NCI Dictionary of Cancer Terms T-3; triiodothyronine
FDA UNII 8NZ4Y08T96
UNSPSC Code 41116107
NACRES NA.26

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302+H312+H332
Precautionary statements  P261-P264-P280-P301+P312-P302+P352+P312-P304+P340+P312
target organs Eyes,Central nervous system
Hazard Codes  Xn,T,F
Risk Statements  36/37/38-20/21/22-39/23/24/25-23/24/25-11
Safety Statements  36-45-36/37-16
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  3
RTECS  AY6750000
F  8
HS Code  29379000
Storage Class 3 - Flammable liquids
Hazard Classifications Acute Tox. 3 Dermal
Acute Tox. 3 Inhalation
Acute Tox. 3 Oral
Aquatic Chronic 3
Flam. Liq. 2
STOT SE 1
NFPA 704
0
3 0

REVERSE T3 price More Price(80)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T-075 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution 100?μg/mL in methanol with 0.1N NH3, ampule of 1?mL, certified reference material, Cerilliant? 5817-39-0 1mL $144 2026-04-30 Buy
Cayman Chemical 17598 3,3'',5''-Triiodo-L-thyronine ≥95% 5817-39-0 5mg $109 2026-04-30 Buy
Cayman Chemical 17598 3,3'',5''-Triiodo-L-thyronine ≥95% 5817-39-0 10mg $207 2026-04-30 Buy
Cayman Chemical 17598 3,3'',5''-Triiodo-L-thyronine ≥95% 5817-39-0 25mg $464 2026-04-30 Buy
Cayman Chemical 17598 3,3'',5''-Triiodo-L-thyronine ≥95% 5817-39-0 50mg $818 2026-04-30 Buy
Product number Packaging Price Buy
T-075 1mL $144 Buy
17598 5mg $109 Buy
17598 10mg $207 Buy
17598 25mg $464 Buy
17598 50mg $818 Buy

REVERSE T3 Chemical Properties,Uses,Production

Description

Either a derivative or precursor of thyroxine. Triiodothyronine increases themetabolic rate and oxygen consumption of animal tissues. Used in biochemical research, medicine (metabolic insufficiency).

Chemical Properties

Beige Powder

Uses

Of interest for the early detection and treatment of congenital or drug-induced hypothyroidism in the developing human fetus.

Uses

One of the hormones produced by the thyroid gland that is involved in the maintenance of metabolic homeostasis. Also produced in peripheral tissues as the active metabolite of Thyroxine.

Definition

ChEBI: 3,3',5'-triiodo-L-thyronine is a 3,3',5'-triiodothyronine. It is a tautomer of a 3,3',5'-triiodo-L-thyronine zwitterion.

Biological Activity

3,3',5'-triiodo-l-thyronine (reverse t3 or rt3) and 3,5,3'-triiodo-l-thyronine (t3) are the metabolism of thyroxine (t4) [1]. 3,3',5'-triiodo-l-thyronine is thyroid hormone receptors trα and trβ antagonist [1].thyroid hormones play important roles in the development of the mammalian brain by acting on migration and differentiation of neural cells, synaptogenesis, and myelination. the actions of thyroid hormones are mediated by nuclear thyroid hormone receptors (trs) and regulation of gene expression. trs have been also involved in adult brain function. in adult mice, trα1 deletion and a dominant negative mutant receptor expression induce consistent behavioral changes leading to severe anxiety and morphological changes in the hippocampus [2].the rt3 was about 1,000-fold less active at the thyroid hormone receptors trα and trβ compared with 3,3',5-triiodo-l-thyronine and commonly described as inactive [1].it has been reported that rt3 activates a native form of trα, trδα1, which lacks a nuclear localization signal and functions in the cytoplasm. through this action, rt3 initiates actin polymerization, particularly in astrocytes and neurons [3].

References

[1] nicod p, burger a, staeheli v, et al. a radioimmunoassay for 3, 3′, 5′-triiodo-l-thyronine in unextracted serum: method and clinical results[j]. the journal of clinical endocrinology & metabolism, 1976, 42(5): 823-829.
[2] bernal j. thyroid hormone receptors in brain development and function[j]. nature clinical practice endocrinology & metabolism, 2007, 3(3): 249-259.
[3] senese r, cioffi f, de lange p, et al. thyroid: biological actions of ‘nonclassical’thyroid hormones[j]. journal of endocrinology, 2014, 221(2): r1-r12.

REVERSE T3 synthesis

59302-19-1
5817-39-0
Synthesis of REVERSE T3 from N-Acetyl-3-iodo-L-tyrosine, Amide

REVERSE T3 Preparation Products And Raw materials

Raw materials

Preparation Products

REVERSE T3 Suppliers

Global( 262)Suppliers
Supplier Tel Email Country ProdList Advantage
Dingwang Technology (Wuhan) Co., Ltd.
+undefined-27-2786652399 +undefined13627115097 market02@senwayer.com China 887 58
Shenzhen Monkono Technology Co.,Ltd
+86-17063441314 sansbiotech@outlook.com China 677 58
Shaanxi Dideu Medichem Co. Ltd 		+86-29-81139210 17389186172 1077@dideu.com China 3796 58
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998 sales@czwytech.com CHINA 904 58
Shochem(Shanghai) Co.,Ltd 		86-21-50800795 info@shochem.com CHINA 288 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14332 58
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19936 58
Shanghai Longyu Biotechnology Co., Ltd. 		info@longyupharma.com China 2430 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29792 58
Suzhou Ryan Pharmachem Technology Co.,Ltd. 		+86-512-68780025 sales@ryanchem.com China 169 58
Supplier Advantage
Dingwang Technology (Wuhan) Co., Ltd.
58
Shenzhen Monkono Technology Co.,Ltd
58
Shaanxi Dideu Medichem Co. Ltd 		58
Cangzhou Wanyou New Material Technology Co.,Ltd 		58
Shochem(Shanghai) Co.,Ltd 		58
Standardpharm Co. Ltd. 		58
BOC Sciences 		58
Shanghai Longyu Biotechnology Co., Ltd. 		58
career henan chemical co 		58
Suzhou Ryan Pharmachem Technology Co.,Ltd. 		58

View Lastest Price from REVERSE T3 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
REVERSE T3 pictures 2026-07-15 REVERSE T3
5817-39-0
 $35.00-139.00 98.89% 10g TargetMol Chemicals Inc.
REVERSE T3 pictures 2025-12-12 REVERSE T3
5817-39-0
 $1.00-4.00 1KG 99% 200000KG Shaanxi Dideu Medichem Co. Ltd
Triiodothyronine/REVERSE T3 pictures 2025-08-22 Triiodothyronine/REVERSE T3
5817-39-0
 $8470.00 1KG 99% min 20 TONS Dingwang Technology (Wuhan) Co., Ltd.
  • REVERSE T3 pictures
  • REVERSE T3
    5817-39-0
  • $35.00-139.00
  • 98.89%
  • TargetMol Chemicals Inc.
  • REVERSE T3 pictures
  • REVERSE T3
    5817-39-0
  • $1.00-4.00
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd

REVERSE T3 Spectrum

REVERSE T3(5817-39-0)1HNMR

5817-39-0(REVERSE T3)Related Search:

Sodium levothyroxine 3,3',5-Triiodo-L-thyronine Benzenepropanoic acid, 5-[4-(cyclopentyloxy)-2-hydroxybenzoyl]-2-[(2,3-dihydro-3-oxo-1,2-benzisoxazol-6-yl)Methoxy]- T0901317 T5601640
Thyroxine-4-hydroxy-3,5-diiodophenyl Ether DISCONTINUED 4-(4-Hydroxyphenoxy)-3,5-diiodo-benzaldehyde 3,5-DIIODO-4'-(4-HYDROXYPHENOXY)BENZOIC ACID Levothyroxine EP Impurity B Levothyroxine Impurity 16
N-ForMyl Thyroxine 3,5,3',5'-Tetraiodo Thyroaldehyde Levothyroxine O-Methyl Amine Impurity O-(4-hydroxy-3-iodophenyl)-3-iodo-L-tyrosine 3,5-Diiodo-4-(p-Methoxyphenoxy)-benzaldehyde
3,5-Diiodo-L-thyronine 3,3',5-TRIIODOTHYROPROPIONIC ACID 3-IODO-L-TYROSINE

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Reverse T3 (3,3',5'-Triiodo-L-Thyronine) L-Tyrosine,O-(4-hydroxy-3,5-diiodophenyl)-3-iodo- (2S)-2-aMino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid REVERSE T3 LIOTHYRONIN L-3,3',5'-TRIIODOTHYRONINE 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution Levothyroxine EP Impurity K 3,3',5'-TRIIODO-L-THYRONINE, THYROID Reverse L-triiodothyronine (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl)propanoic acid Levothyroxine Impurity 10（Levothyroxine EP Impurity K） Levothyroxine Impurity K Reverse T3 3,3',5'-triiodo-L-thyronine free acid Isoliothyronine 3,3’,5-Triiodo-L-thyronine-13C6 3,3’,5-Triiodothyronine-13C6 Liothyronine-13C6 L-T3-13C6 O-(4-Hydroxy-3-iodophenyl)-3,5-diiodo-L-tyrosine-13C6 T3 (Hormone)-13C6 Tresitope-13C6 Triiodothyronine-13C6 (3,5,3')-TRIIODO-L-THYRONINE (S)-3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-2-aminopropanoic acid triiodothyronine,reverse 3,3′,5′-Triiodo-L-thyronine 3,3′,5′-Triiodo-L-thyronine 3,3′,5′-Triiodo-L-thyronine thyroid horMone analog O-(4-hydroxy-3,5-diiodophenyl)-3-iodo-L-Tyrosine Levothyroxine EP Imp K 3, 3', 5'- Triiodothyronine (Solution) Triiodothyronine (L-Liothyronine Reverse Triiodothyronine hydrochloride (Reverse T3) (S)-2-Amino-3-(4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyL REVERSE T3 USP/EP/BP Levothyroxine EP Impurity KQ: What is Levothyroxine EP Impurity K Q: What is the CAS Number of Levothyroxine EP Impurity K Q: What is the storage condition of Levothyroxine EP Impurity K Q: What are the applications of Levothyroxine EP Impurity K 3,3',5'-L-Triiodothyronine 3,3',5'-T3 Alanine,3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]-, L- (8CI) 6-Tetramethyl-4-piperidinone Triiodothyronine。REVERSE T3 Levothyroxine Sodium Impurity K Levothyroxine Sodium EP Impurity K Levothyroxine EP Impurity K (3,3',5'-Triiodo-L-thyronine) Liothyronine Triiodothyronin 3, 3', 5'- Triiodothyronine 3,3',5'-Triiodo-L-thyronine 3,3'',5''-Triiodo-L-thyronine 3,3',5'-triiodo-L-thyronine(T3) Levothyroxine t3 3',5',3-Triiodothyronine 3.3‘.5‘- Triiodothyronine (Rev T3) in Methanol 3,3',5'-triiodo-L-thyroninefreeacid (2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic Acid (3,3',5'-Triiodo-L-Thyro 3,3′,5′-Triiodo-L-thyronine (Reverse T3) solution 3,3′,5′-Triiodo-L-thyronine Zebrafish triiodothyronine (T3) ELISA Kit