T5601640
- CAS No.
- 924473-59-6
- Chemical Name:
- T5601640
- Synonyms
- T5601640;T56-LIMKi;T56-LIMKi ，S6498;T-5601640(T56-LIMKi);T56-LIMKi - T5601640;T56-LIMKi, 10 mM in DMSO;T5601640;T 5601640;T56-LIMKI;3-Methyl-N-(3-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoxazole-5-carboxamide;3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide;3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide
- CBNumber:
- CB33163675
- Molecular Formula:
- C19H14F3N3O3
- Molecular Weight:
- 389.33
- MDL Number:
- MFCD08495674
- MOL File:
- 924473-59-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| T56-LIMKi ≥98% (HPLC) | SML1305 | 25MG | $451 |
| T56-LIMKi ≥98% (HPLC) | SML1305 | 5MG | $105 |
| T5601640 ≥98% | 22140 | 1mg | $36 |
| T5601640 ≥98% | 22140 | 5mg | $117 |
| T5601640 ≥98% | 22140 | 10mg | $208 |
| More product size | |||
| Boiling point | 403.4±45.0 °C(Predicted) |
|---|---|
| Density | 1.426±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml |
| form | powder |
| pka | 11.41±0.70(Predicted) |
| color | white to beige |
| InChI | 1S/C19H14F3N3O3/c1-11-8-16(28-25-11)18(27)24-14-6-2-4-12(9-14)17(26)23-15-7-3-5-13(10-15)19(20,21)22/h2-10H,1H3,(H,23,26)(H,24,27) |
| InChIKey | XVOKFRPKSAWELK-UHFFFAOYSA-N |
| SMILES | O=C(NC1=CC(C(F)(F)F)=CC=C1)C2=CC(NC(C3=CC(C)=NO3)=O)=CC=C2 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H413 |
| Precautionary statements | P273-P301+P310+P330 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 4 |
T5601640 price More Price(67)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1305 | T56-LIMKi ≥98% (HPLC) | 924473-59-6 | 25MG | $451 | 2023-01-07 | Buy |
| Sigma-Aldrich | SML1305 | T56-LIMKi ≥98% (HPLC) | 924473-59-6 | 5MG | $105 | 2022-05-15 | Buy |
| Cayman Chemical | 22140 | T5601640 ≥98% | 924473-59-6 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 22140 | T5601640 ≥98% | 924473-59-6 | 5mg | $117 | 2026-04-30 | Buy |
| Cayman Chemical | 22140 | T5601640 ≥98% | 924473-59-6 | 10mg | $208 | 2026-04-30 | Buy |
T5601640 Chemical Properties,Uses,Production
Uses
T 5601640 is a LIMK inhibitor and is used for the treatment of proliferative disorders such as cancer, neurofibromatosis and neuronal differentiation associated disaeses.
Biochem/physiol Actions
T56-LIMKi is a LIMK2 inhibitor that reduces phosphorylated cofilin, and induces disassembly of actin stress fibers in NF1-/- MEFs cells.
in vivo
T56-LIMKi can induce inhibition of cofilin phosphorylation and Panc-1 tumor shrinkage in vivo. Mice treated with T56-LIMKi (60 mg/kg) shows a significant decrease in tumor volume compared to control[1].
IC 50
LIMK2
storage
Store at +4°C
T5601640 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32468 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30224 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11680 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9942 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
