KURARINONE
- CAS No.
- 34981-26-5
- Chemical Name:
- KURARINONE
- Synonyms
- Kurarinon;Marini;KURARINONE;Kurarinone >=98% (HPLC);Kurarinone, 10 mM in DMSO;2-(2,4-dihydroxyphenyl)-5,7-dihydroxy-8-(5-methyl-2-prop-1-en-2-ylhex-4-enyl)-2,3-dihydrochromen-4-one;(S)-2-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-8-((R)-5-methyl-2-(prop-1-en-2-yl)hex-4-en-1-yl)chroman-4-one;2-(2,4-Dihydroxyphenyl)-2,3-dihydro-7-hydroxy-5-methoxy-8-[5-methyl-2-(1-methylethenyl)-4-hexenyl]-4H-1-benzopyran-4-one;4H-1-Benzopyran-4-one,2-(2,4-dihydroxyphenyl)-2,3-dihydro-7-hydroxy-5-methoxy-8-[(2R)-5-methyl-2-(1-methylethenyl)-4-hexen-1-yl]-,(2S)-
- CBNumber:
- CB5230365
- Molecular Formula:
- C26H30O6
- Molecular Weight:
- 438.51
- MDL Number:
- MFCD03411889
- MOL File:
- 34981-26-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 117-119℃ |
|---|---|
| Boiling point | 651.4±55.0 °C(Predicted) |
| Density | 1+-.0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc. |
| form | Powder |
| pka | 7.49±0.40(Predicted) |
| color | Light yellow to yellow |
| biological source | (isolated from Caragana sinica) |
| InChI | 1S/C25H28O6/c1-13(2)5-6-15(14(3)4)9-18-20(28)11-21(29)24-22(30)12-23(31-25(18)24)17-8-7-16(26)10-19(17)27/h5,7-8,10-11,15,23,26-29H,3,6,9,12H2,1-2,4H3 |
| InChIKey | XRYVAQQLDYTHCL-UHFFFAOYSA-N |
| SMILES | CC([C@H](CC=C(C)C)CC1=C2C(C(C[C@@H](C3=CC=C(O)C=C3O)O2)=O)=C(OC)C=C1O)=C |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
KURARINONE price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 38966 | Kurarinone ≥98% | 1049662-21-6 | 5mg | $149 | 2026-04-30 | Buy |
| Cayman Chemical | 38966 | Kurarinone ≥98% | 1049662-21-6 | 10mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 38966 | Kurarinone ≥98% | 1049662-21-6 | 25mg | $594 | 2026-04-30 | Buy |
| Cayman Chemical | 38966 | Kurarinone ≥98% | 1049662-21-6 | 50mg | $1040 | 2026-04-30 | Buy |
| ChemScene | CS-0019608 | Kurarinone 99.47% | 34981-26-5 | 5mg | $162 | 2026-06-04 | Buy |
KURARINONE Chemical Properties, Uses, Production
Uses
Kurarinone is an orally active flavonoid isolated from matrine that inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting cell differentiation of Th1 and Th17. Kurarinone has antitumor and anti-inflammatory activity[1][2][3].
Definition
ChEBI: (2S)-(-)-kurarinone is a trihydroxyflavanone that is (2S)-flavanone substituted by hydroxy groups at positions 7, 2' and 4', a lavandulyl group at position 8 and a methoxy group at position 5. Isolated from the roots of Sophora flavescens, it exhibits cytotoxicity against human myeloid leukemia HL-60 cells. It has a role as a metabolite and an antineoplastic agent. It is a trihydroxyflavanone, a monomethoxyflavanone and a member of 4'-hydroxyflavanones. It is functionally related to a (2S)-flavanone.
Biological Activity
Kurarinone, a flavonoid isolated from Sophora flavescens, inhibits the pathogenesis of experimental autoimmune encephalomyelitis by inhibiting the differentiation of Th1 and Th17 cells.
Physiological effects
Kurarinon has an anti-endothelial cell proliferative activity, and it has a significant inhibitory effect on endothelial cell proliferation with a median inhibitory concentration (IC50) of 12ug/ml.
in vivo
Kurarinone (100 mg/kg, oral, days 21-42) has therapeutic effects in a collagen-induced arthritis (CIA) mouse model[3].
Kurarinone (100 mg/kg, po, from day 21-42) has a therapeutic effect in a mouse model of collagen-induced arthritis (CIA)[3].
| Animal Model: | CIA Mouse Model[3] |
| Dosage: | 100 mg/kg |
| Administration: | po |
| Result: | Reduced the levels of proinflammatory cytokines, TNF-α, IL-6, IFN-γ, and IL-17A. Reduced STAT1 and STAT3 phosphorylation and the proportions of Th1 and Th17 cells in lymph nodes. |
References
[1] Xie L, et al. The flavonoid kurarinone inhibits clinical progression of EAE through inhibiting Th1 and Th17 cell differentiation and proliferation. Int Immunopharmacol. 2018 Sep;62:227-236. DOI:10.1016/j.intimp.2018.06.022
[2] Nishikawa S, et al. Kurarinone from Sophora Flavescens Roots Triggers ATF4 Activation and Cytostatic Effects Through PERK Phosphorylation. Molecules. 2019 Aug 27;24(17):3110. DOI:10.3390/molecules24173110
[3] Tang KT, et al. Kurarinone Attenuates Collagen-Induced Arthritis in Mice by Inhibiting Th1/Th17 Cell Responses and Oxidative Stress. Int J Mol Sci. 2021 Apr 13;22(8):4002. DOI:10.3390/ijms22084002
KURARINONE Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16306 | 64 |
| BioBioPha Co., Ltd. | 0871-65217109 | y.liu@mail.biobiopha.com | China | 5641 | 65 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-028-82633397 18982077548 | cwb1@biopurify.cn | China | 2376 | 60 |
| The future of Shanghai Industrial Co., Ltd. | 021-61552785 | sales@shshiji.com | China | 9531 | 55 |
| Shanghai Tauto Biotech Co., Ltd. | 021-51320588 | tauto@tautobiotech.com | China | 3984 | 66 |
| Cheng Du Pufeide Biotechnology Co., Ltd. | 028-82610909 13388174823 | scglp@glp-china.com | China | 1064 | 58 |
| Shanghai JONLN Reagent Co., Ltd. | 400-0066400 13621662912 | 422131432@qq.com | China | 9970 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
View Latest Price from KURARINONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | Kurarinone
34981-26-5
|
$39.00-197.00 | 98.34% | 10g | TargetMol Chemicals Inc. | ||
 |
2024-08-11 | KURARINONE
34981-26-5
|
$1.00 | 1KG | 99% | 20T | Shaanxi Dideu Medichem Co. Ltd | |
 |
2023-02-24 | Kurarinone
34981-26-5
|
5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. |
-
- Kurarinone
34981-26-5
- $39.00-197.00
- 98.34%
- TargetMol Chemicals Inc.
-
- KURARINONE
34981-26-5
- $1.00
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Kurarinone
34981-26-5
- $0.00
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
