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ChemicalBook >> CAS DataBase List >>2-Chloro-1,5-naphthyridine

2-Chloro-1,5-naphthyridine

2-Chloro-1,5-naphthyridine Structure
2-Chloro-1,5-naphthyridine structure
CAS No.
7689-62-5
Chemical Name:
2-Chloro-1,5-naphthyridine
Synonyms
2-Chloro-1,5-naphthyridine;1,5-Naphthyridine, 2-chloro-
CBNumber:
CB52484715
Molecular Formula:
C8H5ClN2
Molecular Weight:
164.59
MDL Number:
MFCD13189452
MOL File:
7689-62-5.mol
MSDS File:
SDS
Last updated:2026-05-28 02:00:40
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2-Chloro-1,5-naphthyridine Properties

Melting point 109-111℃
Boiling point 281℃
Density 1.349
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
pka 1.32±0.10(Predicted)
Appearance White to off-white Solid
InChI InChI=1S/C8H5ClN2/c9-8-4-3-6-7(11-8)2-1-5-10-6/h1-5H
InChIKey JUYRQGHDOBBUEA-UHFFFAOYSA-N
SMILES N1C2C(=NC=CC=2)C=CC=1Cl

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H335-H319-H315-H312-H302-H332
Precautionary statements  P264-P280-P305+P351+P338-P337+P313P-P264-P280-P302+P352-P321-P332+P313-P362-P280-P302+P352-P312-P322-P363-P501-P261-P271-P304+P340-P312-P264-P270-P301+P312-P330-P501
HS Code  2933998090

2-Chloro-1,5-naphthyridine price More Price(59)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Apolloscientific OR933028 2-Chloro-1,5-naphthyridine 97% 7689-62-5 100mg $44 2026-06-04 Buy
Apolloscientific OR933028 2-Chloro-1,5-naphthyridine 97% 7689-62-5 250mg $62 2026-06-04 Buy
Apolloscientific OR933028 2-Chloro-1,5-naphthyridine 97% 7689-62-5 1g $146 2026-06-04 Buy
Apolloscientific OR933028 2-Chloro-1,5-naphthyridine 97% 7689-62-5 5g $500 2026-06-04 Buy
Apolloscientific OR933028 2-Chloro-1,5-naphthyridine 97% 7689-62-5 25g $1745 2026-06-04 Buy
Product number Packaging Price Buy
OR933028 100mg $44 Buy
OR933028 250mg $62 Buy
OR933028 1g $146 Buy
OR933028 5g $500 Buy
OR933028 25g $1745 Buy

2-Chloro-1,5-naphthyridine Chemical Properties, Uses, Production

Synthesis

1,5-naphthyridine N-(1)-oxide

27305-48-2

2-Chloro-1,5-naphthyridine

7689-62-5

4-CHLORO-1,5-NAPHTHYRIDINE

7689-63-6

(2) Synthesis of 2-chloro-1,5-diazanaphthalene. A 50 mL round bottom flask was charged with 1,5-diazanaphthalene N-oxide (98 mg, 1.355 mmol) and phosphorochloride (2 mL, 21.457 mmol). The reaction mixture was placed in an oil bath at 100 °C and the reaction was stirred for 8 hours. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was neutralized with saturated NaHCO3 solution (2 mL) and extracted with ethyl acetate (2 x 20 mL). The organic phases were combined, washed with saturated NaCl solution (2 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with 60% ethyl acetate/hexane as eluent to afford 2-chloro-1,5-diazanaphthalene (78 mg, 35% yield). Mass spectrum (ESI positive ion mode) m/z: calculated value C8H5ClN2 [M+H]+ 165.0, measured value 165.0. 1H NMR (300 MHz, CDCl3) δ ppm: 7.64 (d, J=8.77 Hz, 1H), 7.66-7.72 (m, J=4.38 Hz, 1H), 8.35 (t, J=8.77 Hz, 2H), 8.99 (dd, J=4.17,1.68Hz, 1H). 4-Chloro-1,5-diazaphthalene (86 mg, 39% yield) was also isolated. Mass spectrum (ESI positive ion mode) m/z: calculated value C8H5ClN2 [M+H]+ 165.0, measured value 165.0. 1H NMR (300 MHz, CDCl3) δ ppm: 7.75 (dd, J=8.55,4.17Hz, 1H), 7.79 (d, J=4.68Hz, 1H), 8.47 (dd, J=8.62,1.68Hz, 1H), 8.47 (dd, J=8.62,1.62Hz, 1.68Hz, 1H). 8.62,1.61Hz, 1H), 8.87 (d, J=4.68Hz, 1H), 9.11 (dd, J=4.09,1.61Hz, 1H).

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4735 - 4751
[2] Patent: WO2009/155121, 2009, A2. Location in patent: Page/Page column 104

2-Chloro-1,5-naphthyridine Preparation Products And Raw materials

Raw materials

2-Hydroxy-1,5-naphthyridine 1,5-naphthyridine N-(1)-oxide

Preparation Products

2-Chloro-1,5-naphthyridine Suppliers

Global Suppliers ( 68)
Supplier Tel Email Country ProdList Advantage
Carbott PharmTech Inc. 0535-6385396 info@carbottpharm.com China 996 56
PharmaBlock Sciences (Nanjing),Inc. 025-86918202 4000255188 sales@pharmablock.com China 5000 55
SynAsst Chemical. 021-60343070 China 12731 55
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 微信 18019252918 18019252918 sale@amkchem.com China 14982 55
Tianjin Anhao Biological Technology Co., Ltd. sales@ahpharmatech.com China 5734 55
Shanghai HuanChuan Industry Co.,Ltd. 021-61478794 sales@hcshhai.com China 9781 50
Accela ChemBio Inc. +1(858) 699-3322 marketing@accelachem.com United States 6022 65
Shanghai Boyners Pharm-Tech Co., Ltd. 13817873692 mkt@boynerspharm.com China 1707 55
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Supplier Advantage
Carbott PharmTech Inc. 56
PharmaBlock Sciences (Nanjing),Inc. 55
SynAsst Chemical. 55
Bide Pharmatech Ltd. 60
ShangHai AmK Pharmaceutical Technology Co., Ltd. 55
Tianjin Anhao Biological Technology Co., Ltd. 55
Shanghai HuanChuan Industry Co.,Ltd. 50
Accela ChemBio Inc. 65
Shanghai Boyners Pharm-Tech Co., Ltd. 55
Shanghai YuanYe Biotechnology Co., Ltd. 60

View Latest Price from 2-Chloro-1,5-naphthyridine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-1,5-naphthyridine pictures 2019-12-31 2-Chloro-1,5-naphthyridine
7689-62-5
 1g 95%min 20kg/month Nanjing jinheyou Trading Co., Ltd.

2-Chloro-1,5-naphthyridine Spectrum

2-Chloro-1,5-naphthyridine(7689-62-5)1HNMR

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