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XtalFluor-E

XtalFluor-E structure

CAS No.: 63517-29-3

Chemical Name:: XtalFluor-E

Synonyms: DiethylaMinodifluorosulfiniuM tetrafluoroborate;(Diethylamino)difluorosulfonium tetrafluoroborate;tetrafluoroboranuide;1-fluoro-2,4,6-trimethylpyridin-1-ium;triethylphosphanium;DAST difluorosulfinium salt;3,5-dichloro-1-fluoropyridin-1-ium;diethylamino(difluoro)sulfanium,tetrafluoroborate;N,N-Diethylamino-S,S-difluorosulfinium tetrafluoroborate;Xtalfiuor-E

CBNumber:: CB52491469

Molecular Formula:: C4H10BF6NS

Molecular Weight:: 228.9953192

MDL Number:: MFCD15144877

MOL File:: 63517-29-3.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-04 16:00:12

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XtalFluor-E Properties

Melting point	84-87℃
storage temp.	-20°C
form	solid
Appearance	Off-white to light brown Solid
InChI	InChI=1S/C4H10F2NS.BF4/c1-3-7(4-2)8(5)6;2-1(3,4)5/h3-4H2,1-2H3;/q+1;-1
InChIKey	YLNKFQWRRIXZPJ-UHFFFAOYSA-N
SMILES	S(F)(F)=[N+](CC)CC.[B-](F)(F)(F)F
UNSPSC Code	12352101
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS05,GHS06
Signal word	Danger
Hazard statements	H301+H311+H331-H314
Precautionary statements	P260-P270-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes	T
Risk Statements	23/24/25-34
Safety Statements	26-36/37/39-45
RIDADR	UN 2923 8/PG 3
WGK Germany	3
HazardClass	8, 6.1
Storage Class	6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects
Hazard Classifications	Acute Tox. 3 Dermal Acute Tox. 3 Inhalation Acute Tox. 3 Oral Eye Dam. 1 Skin Corr. 1B
Limited Quantities	1 Kg (2.2 lbs) (solid)
Excepted Quantities	Max Inner Pack (30g or 30ml) and Max Outer Pack (500g or 500ml)

XtalFluor-E price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	719439	XtalFluor-E®	63517-29-3	5G	$57.9	2026-04-30	Buy
Sigma-Aldrich	719439	XtalFluor-E®	63517-29-3	25G	$224	2026-04-30	Buy
Sigma-Aldrich	719439	XtalFluor-E®	63517-29-3	250G	$1750	2026-04-30	Buy
Sigma-Aldrich	719439	XtalFluor-E®	63517-29-3	1KG	$5700	2026-04-30	Buy
Biosynth	FX31882	XtalFluor-E	63517-29-3	0.5kg	$973.5	2026-06-04	Buy

Product number	Packaging	Price	Buy
719439	5G	$57.9	Buy
719439	25G	$224	Buy
719439	250G	$1750	Buy
719439	1KG	$5700	Buy
FX31882	0.5kg	$973.5	Buy

XtalFluor-E Chemical Properties, Uses, Production

Description

XtalFluor-E, [Et2NSF2]BF4, is best known as a useful, versatile and inexpensive commercially available reagent for the deoxyfluorination of carbonyl compounds and alcohols. Although XtalFluor-E is commonly used in combination with an exogenous fluoride source as a deoxofluorinating reagent, it has also been widely employed in other chemical transformations such as dehydration, cyclodehydration, ring expansion, formylation, and proto-functionalization, etc.

Uses

XtalFluor-E [(F2SNEt2)BF4] is an efficient coupling reagent for amidation of carboxylic acids with amines under mild conditions (THF, 0°C to room temperature) and easy workup (Na2CO3, H2O). XtalFluor-E was further applied in peptide synthesis, producing dipeptides with excellent diastereomeric excess. The study concludes that XtalFluor-E is a versatile and mild reagent for amide bond formation, offering high efficiency and substrate compatibility without compromising optical integrity.^[3]

Uses

XtalFluor-E can be used as convenient crystalline highly chemoselective deoxofluorination reagent with a broad substrate scopeDeoxofluorination reagent with a better safety profile.

Application

Convenient crystalline highly chemoselective deoxofluorination reagent with a broad substrate scope
Deoxofluorination reagent with a better safety profile, that doesn′t generate corrosive HF which makes it suitable for use in standard borosilicate vessels, and does not react violently with water
Reactant for:
Preparation of fluorodisaccharides
Triisopropylsilanethiol was recently reported by MacMillian and coworkers to be used as an organocatalyst, in tandem with Ir(III) specifically Aldrich product 688096, in photoredox catalysis. This approach directly couples a cyano-containing arene with an allylic sp3 C-H bond.

References

1.XtalFluor-E: A useful and versatile reagent in organic transformations
(DOI): 10.1016/j.jfluchem.2019.06.006
2.XtalFluorE effects the C3H sulfenylation of indoles to form di indole sulfides
(DOI): 10.1002/ejoc.202101394
3.AURÉLIE ORLIAC. XtalFluor-E, an Efficient Coupling Reagent for Amidation of Carboxylic Acids[J]. Organic Letters, 2013, 15 4: 902-905. DOI:10.1021/ol400045d.

XtalFluor-E Preparation Products And Raw materials

Raw materials

Preparation Products

XtalFluor-E Suppliers

Global Suppliers ( 116)

Supplier	Tel	Email	Country	ProdList	Advantage
BTC Pharmaceutical CO. Ltd	+86-15716293042 15716293042	info@btcpharm.com	China	822	55
SHANG FLUORO	021-65170832 15601903708	qinba_1@163.com	China	401	60
Beijing HwrkChemical Technology Co., Ltd	89508211 18501085097	sales.bj@hwrkchemical.com	China	9407	55
Energy Chemical	400-0056266	sales8178@energy-chemical.com	China	44850	61
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Shanghai Sunway Pharmaceutical Technology Co., Ltd	13761987713	hxzheng@sunwaypharm.cn	China	8663	57
Shanghai Topbiochem Technology Co., Ltd	+86-21-60341587	sales@topbiochem.com	China	6166	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	400-6206333 13167063860	anhua.mao@aladdin-e.com	China	29977	65
Shanghai Arbor Chemical Co., Ltd.	021-60451683 15021268886	sales@arborchemical.com	China	837	55
Shanghai Yolne Chemical Co., Ltd.	021-62960152	934678158@qq.com	China	9886	55

Supplier	Advantage
BTC Pharmaceutical CO. Ltd	55
SHANG FLUORO	60
Beijing HwrkChemical Technology Co., Ltd	55
Energy Chemical	61
Accela ChemBio Co.,Ltd.	64
Shanghai Sunway Pharmaceutical Technology Co., Ltd	57
Shanghai Topbiochem Technology Co., Ltd	58
Shanghai Aladdin Bio-Chem Technology Co.,LTD	65
Shanghai Arbor Chemical Co., Ltd.	55
Shanghai Yolne Chemical Co., Ltd.	55

View Latest Price from XtalFluor-E manufacturers

Update time	Product	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	(Diethylamino)difluorosulfonium Tetrafluoroborate 63517-29-3	1KG	95%min	30tons/month	WUHAN FORTUNA CHEMICAL CO., LTD
2026-09-11	XtalFluor-E 63517-29-3	100g	97%	500g,1kg,5kg,10kg,50kg,100kg...	Zjartspharm Co., Ltd
2025-04-04	XtalFluor-E 63517-29-3	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.

(Diethylamino)difluorosulfonium Tetrafluoroborate
63517-29-3
$0.00
95%min
WUHAN FORTUNA CHEMICAL CO., LTD

XtalFluor-E
63517-29-3
$0.00
97%
Zjartspharm Co., Ltd

XtalFluor-E
63517-29-3
98%
Henan Aochuang Chemical Co.,Ltd.

XtalFluor-E Spectrum

XtalFluor-E(63517-29-3)¹HNMR

63517-29-3 (XtalFluor-E) Related Search:

XtalFluor-M Ethanaminium, N-(difluoro-λ4-sulfanylidene)-N-ethyl- XtalFluor-E

N,N-Diethyl-S,S-difluorosulfiliminium tetrafluoroborate XtalFluor-E(R) XtalFluor-E Xtalfiuor-E N-(Difluoro-λ4-sulfanylidene)-N-ethyl-ethanaminium tetrafluoroborate (difluoro-λ-sulfanylidene)diethylazanium 4-acetyl-3-phenylpiperazin-1-ium iethylamino(difluoro)sulfanium,tetrafluoroborate 1-butylpyridin-1-ium di-tert-butyl(phenyl)phosphanium 4-(difluoro--sulfanylidene)-4-morpholin-4-ylium 2-(methoxycarbonyl)thiophene-3-diazonium 4-tert-butyl-2,6-dimethyl-1-pyran-1-ylium 2-bromo-1-methylpyridin-1-ium methyldiphenylsulfanium 1-propyl-2-(1,2,2,2-tetrafluoroethyl)pyridin-1-ium 1-methoxy-4-phenylpyridin-1-ium 2-ethyl-1,3-dimethyl-1H-1,3-benzodiazol-3-ium 1-(dimethyl-2H-1,3-dithiol-2-ylidene)-1-piperidin-1-ylium 1-(cyanomethyl)-2,4,6-trimethylpyridin-1-ium 1,3-dimethyl-2-(trifluoromethyl)-1H-1,3-benzodiazol-3-ium 1,3-bis(propan-2-yl)-4,5-dihydro-1H-imidazol-3-ium phenyl[2-(trimethylsilyl)ethynyl]iodanium N,N-dimethylcyclopentaniminium triethylphosphanium trimethyldisulfanium 2,4,6-trimethyl-1-phenyl-1-pyridin-1-ylium 2,4,6-trimethyl-1-(prop-2-en-1-yl)pyridin-1-ium 3-(4-bromophenyl)-4-[1,3]thiazolo[3,2-a]pyridin-4-ylium 1-benzyl-2,4,6-trimethylpyridin-1-ium 1-benzyl-2,6-diethyl-4-phenylpyridin-1-ium 1-[chloro(pyrrolidin-1-yl)methylidene]-1-pyrrolidin-1-ylium 1-[(4-methoxyphenyl)methyl]pyridin-1-ium ethynyl(phenyl)iodanium ethyldiphenylsulfanium [(dimethylamino)[(2-oxo-1,2-dihydropyridin-1-yl)oxy]methylidene]dimethylazanium (dimethylamino)(methyl)oxo(phenyl)--sulfanylium 3,5-dichloro-1-fluoropyridin-1-ium 3,5-bis(trifluoromethyl)benzene-1-diazonium (4-chlorophenyl)(pentafluoroethyl)iodanium 2-tert-butyl-1,3-dimethyl-1H-1,3-benzodiazol-3-ium diethylamino(difluoro)sulfanium TIANFU-CHEM XtalFluor-E (difluoro-λ?-sulfanylidene)-diethyl-ammonium DAST difluorosulfinium saltXtalFluor-E Ethanaminium, N-(difluoro-λ4-sulfanylidene)-N-ethyl-, tetrafluoroborate(1-) (1:1) (difluoro-lambda4-sulfanylidene)-diethyl-ammonium tetrafluoroborate XtalFluor-E^? (Diethylamino)difluorosulfonium tetrafluoroborate 1-fluoro-2,4,6-trimethylpyridin-1-ium DAST difluorosulfinium salt diethylamino(difluoro)sulfanium,tetrafluoroborate DiethylaMinodifluorosulfiniuM tetrafluoroborate N,N-Diethylamino-S,S-difluorosulfinium tetrafluoroborate tetrafluoroboranuide 63517-29-3 C4H10F2NSBF4 Chemical Synthesis