SR 1001
- CAS No.
- 1335106-03-0
- Chemical Name:
- SR 1001
- Synonyms
- SR 1001;SR-1001;SR 1001;SR1001 >=98% (HPLC);SR1001, 10 mM in DMSO;SR1001, RORalpha and RORgammat inverse agonist;N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulfamoyl)-4-methylthiazol-2-yl)acetamide;N-(5-(N-(4-(1,1,1,3,3,3-Hexafluoro-2-hydroxypropan-2-yl)phenyl)sulphamoyl)-4-methylthiazol-2-yl)acetamide;N-(5-{[4-(1,1,1,3,3,3-Hexafluoro-2-hydroxy-2-propanyl)phenyl]sulfamoyl}-4-methyl-1,3-thiazol-2-yl)acetamide;N-[4-Methyl-5-[[[4-[2,2,2-trifluoro-1-hydroxy-1-(trifluoromethyl)ethyl]phenyl]amino]sulfonyl]-2-thiazolylacetamide;SR1001,N-{4-Methyl-5-[4-(2,2,2-trifluoro-1-hydroxy-1-trifluoroMethyl-ethyl)-phenylsulfaMoyl]-thiazol-2-yl}-acetaMide
- CBNumber:
- CB52592586
- Molecular Formula:
- C15H13F6N3O4S2
- Molecular Weight:
- 477.4
- MDL Number:
- MFCD23160036
- MOL File:
- 1335106-03-0.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SR1001 ≥98% (HPLC) | SML0322 | 5mg | $159 |
| SR1001 ≥98% (HPLC) | SML0322 | 25mg | $527 |
| SR 1001 ≥98% | 10922 | 1mg | $36 |
| SR 1001 ≥98% | 10922 | 5mg | $117 |
| SR 1001 ≥98% | 10922 | 10mg | $205 |
| Density | 1.640±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | Sealed in dry,2-8°C |
| solubility | DMSO: >5mg/mL |
| form | powder |
| pka | 5.90±0.50(Predicted) |
| color | white to beige |
| Stability | Stable for 2 years from date of purchase as supplied. Protect from moisture. Solutions in DMSO may be stored at -20° for up to 3 months. |
| InChI | 1S/C15H13F6N3O4S2/c1-7-11(29-12(22-7)23-8(2)25)30(27,28)24-10-5-3-9(4-6-10)13(26,14(16,17)18)15(19,20)21/h3-6,24,26H,1-2H3,(H,22,23,25) |
| InChIKey | OZBSSKGBKHOLGA-UHFFFAOYSA-N |
| SMILES | CC(=O)Nc1nc(C)c(s1)S(=O)(=O)Nc2ccc(cc2)C(O)(C(F)(F)F)C(F)(F)F |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H319 | |||||||||
| Precautionary statements | P264-P270-P280-P301+P312-P305+P351+P338-P337+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 |
|||||||||
| NFPA 704 |
|
SR 1001 price More Price(73)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0322 | SR1001 ≥98% (HPLC) | 1335106-03-0 | 5mg | $159 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML0322 | SR1001 ≥98% (HPLC) | 1335106-03-0 | 25mg | $527 | 2026-04-30 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 1335106-03-0 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 1335106-03-0 | 5mg | $117 | 2026-04-30 | Buy |
| Cayman Chemical | 10922 | SR 1001 ≥98% | 1335106-03-0 | 10mg | $205 | 2026-04-30 | Buy |
SR 1001 Chemical Properties,Uses,Production
Description
SR1001 (1335106-03-0) is a high affinity synthetic ligand for both RORα and RORγt acting as an inverse agonist. It binds specifically to the ligand-binding domain, inducing a conformational change which leads to diminished affinity for co-activators and increased affinity for co-repressors resulting in suppression of transcriptional activity.1SR-1001 inhibits the development of murine TH17 cells2 and suppresses the expression of cytokines1. Suppresses insulitis and prevents hyperglycemia in a type 1 diabetes mouse model.3 Protects against pathologic neovascularization in various mouse models of retinopathy.4Active in vivo
Uses
SR 1001 is a selective RORc inverse agonist.
Definition
ChEBI: SR 1001 is a sulfonamide.
in vivo
SR1001 effectively suppresses the clinical severity of autoimmune disease in mice. Administration of SR1001 to C57BL/6 mice suppresses the expression of hepatic ROR target genes, Cyp7b1, Rev-erbα, and Serpine 1[1]. SR1001 a RORα inverse agonist eliminats the circadian pattern of expression of citrate synthase mRNA in mice[2].
References
[1] LAURA A. SOLT. Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand[J]. Nature, 2011, 472 7344: 491-494. DOI:10.1038/nature10075
[2] ELÉONORE BEUREL Richard S J Laurie E Harrington. Inflammatory T Helper 17 Cells Promote Depression-like Behavior in Mice[J]. Biological Psychiatry, 2013, 73 7: Pages 622-630. DOI:10.1016/j.biopsych.2012.09.021
[3] LAURA A SOLT. ROR inverse agonist suppresses insulitis and prevents hyperglycemia in a mouse model of type 1 diabetes.[J]. Endocrinology, 2015, 156 3: 869-881. DOI:10.1210/en.2014-1677
[4] YE SUN. Nuclear receptor RORα regulates pathologic retinal angiogenesis by modulating SOCS3-dependent inflammation.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2015, 112 33: 10401-10406. DOI:10.1073/pnas.1504387112
SR 1001 Preparation Products And Raw materials
Raw materials
Preparation Products
SR 1001 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| BOC Sciences | 16314854226; +16314854226 | inquiry@bocsci.com | United States | 19853 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8467 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43333 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131956 | 58 |
| Shanghai Xiannuo Biotechnology Co., Ltd. | 021-50718719 13918719472 | China | 979 | 58 | |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
