Ethanone, 2-bromo-1-cyclopropyl-
- CAS No.
- 69267-75-0
- Chemical Name:
- Ethanone, 2-bromo-1-cyclopropyl-
- Synonyms
- 2-Bromo-1-cyclopropylethan-1-one;2-BROMO-1-CYCLOPROPYL ETHANONE;Bromoacetylcyclopropane;Cyclopropylbromomethylketone;Bromomethyl cyclopropylketone;2-bromo-1-cyclopropyl ethenone;2-Bromomethyl Cyclopropylketone;2-Bromo-1-Cycloproplyethan-1-One;1-bromomethyl cyclopropyl ketone;Ethanone, 2-bromo-1-cyclopropyl-
- CBNumber:
- CB5260627
- Molecular Formula:
- C5H7BrO
- Molecular Weight:
- 163.01
- MDL Number:
- MFCD08460238
- MOL File:
- 69267-75-0.mol
- MSDS File:
- SDS
| Boiling point | 60-65 °C(Press: 10 Torr) |
|---|---|
| Density | 1.669 |
| refractive index | 1.543 |
| storage temp. | Inert atmosphere,Store in freezer, under -20°C |
| solubility | Chloroform, Ethyl Acetate (Slightly) |
| form | Liquid |
| color | Clear Colourless |
| InChI | 1S/C5H7BrO/c6-3-5(7)4-1-2-4/h4H,1-3H2 |
| InChIKey | WCCCDMWRBVVYCQ-UHFFFAOYSA-N |
| SMILES | O=C(C1CC1)CBr |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H319 |
| Precautionary statements | P301+P310+P330-P305+P351+P338 |
| Risk Statements | 36 |
| Safety Statements | 26 |
| RIDADR | UN 2811 6.1 / PGIII |
| WGK Germany | WGK 3 |
| HazardClass | IRRITANT |
| HS Code | 2914790090 |
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
| Hazard Classifications | Acute Tox. 3 Oral Eye Irrit. 2 |
Ethanone, 2-bromo-1-cyclopropyl- price More Price(48)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | TMT00623 | 2-Bromo-1-cyclopropylethanone | 69267-75-0 | 1g | $586 | 2026-04-30 | Buy |
| TCI Chemical | B6077 | 2-Bromo-1-cyclopropylethanone min. 95.0 % | 69267-75-0 | 1G | $53 | 2026-04-30 | Buy |
| TCI Chemical | B6077 | 2-Bromo-1-cyclopropylethanone min. 95.0 % | 69267-75-0 | 5G | $162 | 2026-04-30 | Buy |
| Usbiological | 415668 | 2-Bromo-1-cyclopropylethanone | 69267-75-0 | 1g | $319 | 2026-06-03 | Buy |
| Usbiological | 415668 | 2-Bromo-1-cyclopropylethanone | 69267-75-0 | 5g | $482 | 2026-06-03 | Buy |
Ethanone, 2-bromo-1-cyclopropyl- Chemical Properties, Uses, Production
Uses
2-Bromo-1-cyclopropylethanone is an intermediate used to prepare pyrrolo[2,1-f]purine-2,4-dione and imidazo[2,1-f]purine-2,4-dione derivatives as potent and selective human A3 adenosine receptor antagonists. It is also used to synthesize indolizine derivatives incorporating a cyclopropylcarbonyl group against Hep-G2 cancer cell line.
Synthesis
765-43-5
69267-75-0
The general procedure for the synthesis of 1-cyclopropyl-2-bromoacetophenone from cyclopropylmethyl ketone was as follows: a methanol (MeOH, 100 mL) solution of cyclopropylmethyl ketone (20.7 mL, 220 mmol) was treated with bromine (11.3 mL, 220 mmol) at -5 °C and the reaction lasted for 2 hours. Subsequently, 50 mL of water was added to the reaction mixture and the reaction system was slowly warmed to room temperature and left to stand overnight. After completion of the reaction, the mixture was diluted with 150 mL of water and extracted with ether. The organic phase was separated, washed with sodium bicarbonate (NaHCO3) solution, dried over anhydrous sodium sulfate (Na2SO4), and concentrated to remove the solvent to give the light yellow oily product 1-cyclopropyl-2-bromoacetophenone (35 g, 99% yield). The structure of the product was confirmed by 1H NMR (CDCl3): δ 0.91-1.02 (m, 2H), 1.03-1.16 (m, 2H), 2.08-2.20 (m, 1H), 4.02 (s, 2H).
References
[1] Patent: US2010/196321, 2010, A1. Location in patent: Page/Page column 22
[2] Patent: WO2013/184734, 2013, A1. Location in patent: Paragraph 00299; 00300
[3] Synlett, 2010, # 6, p. 873 - 876
[4] Patent: WO2010/96395, 2010, A1. Location in patent: Page/Page column 34
[5] Patent: WO2015/76800, 2015, A1. Location in patent: Page/Page column 318
Ethanone, 2-bromo-1-cyclopropyl- Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Jia Xing Isenchem Co.,Ltd | 0573-85285100 18627885956 | isenchem@163.com | China | 9389 | 66 |
| Accela ChemBio Co.,Ltd. | 021-50795510 4000665055 | marketing@accelachem.com | China | 10972 | 64 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Shanghai Ennopharm Co., Ltd. | +86 (21) 6435-5022 | China | 4263 | 65 | |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Nanjing Kaitian Chemical Co., Ltd. | +86 (25) 5860-8846 | kt_chem@126.com | China | 218 | 62 |
| Atop-Pharma (Shanghai) Technology Co., Ltd. | +86 (21) 5196-9732 | China | 996 | 57 | |
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9509 | 58 |
View Latest Price from Ethanone, 2-bromo-1-cyclopropyl- manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-18 | ETHANONE, 2-BROMO-1-CYCLOPROPYL-
69267-75-0
|
1KG | 95% | 2000 | Shenzhen Nexcon Pharmatechs Ltd. | ||
 |
2019-07-06 | ETHANONE, 2-BROMO-1-CYCLOPROPYL-
69267-75-0
|
$1.00 | 1kg | 98% | 200kg | Career Henan Chemical Co |
-
- ETHANONE, 2-BROMO-1-CYCLOPROPYL-
69267-75-0
- 95%
- Shenzhen Nexcon Pharmatechs Ltd.
-
- ETHANONE, 2-BROMO-1-CYCLOPROPYL-
69267-75-0
- $1.00
- 98%
- Career Henan Chemical Co
