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MK-2206 2HCl

MK-2206 2HCl structure

CAS No.: 1032350-13-2

Chemical Name:: MK-2206 2HCl

Synonyms: MK-2206;MK-2206 Dihydrochloride;CS-260;MK-2206 2HCl;MK-2206 HCl salt;MK-2206 2HCL;MK2206;MK-2206 2HCl ，S1078;Benodanil Impurity 9;MK-2206 2HCl USP/EP/BP;MK 2206 (hydrochloride)

CBNumber:: CB72489901

Molecular Formula:: C25H22ClN5O

Molecular Weight:: 443.94

MDL Number:: MFCD14584463

MOL File:: 1032350-13-2.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-20 20:20:01

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MK-2206 2HCl Properties

Melting point	>255°C (dec.)
storage temp.	-20°C
solubility	Soluble in DMSO (up to 10 mg/ml with warming)
form	Yellow powder.
color	Yellow
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
InChIKey	LFYOZCBFOSSLNJ-UHFFFAOYSA-N
SMILES	O=C1NN=C2C3=CC(C4C=CC=CC=4)=C(C4C=CC(C5(CCC5)N)=CC=4)N=C3C=CN12.Cl
FDA UNII	Q34I3E28IO

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

HS Code

2933998090

NFPA 704

	0
2		0

MK-2206 2HCl price More Price(82)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	11593	MK-2206 (hydrochloride) ≥98%	1032350-13-2	1mg	$48	2026-04-30	Buy
Cayman Chemical	11593	MK-2206 (hydrochloride) ≥98%	1032350-13-2	5mg	$94	2026-04-30	Buy
Cayman Chemical	11593	MK-2206 (hydrochloride) ≥98%	1032350-13-2	10mg	$117	2026-04-30	Buy
Cayman Chemical	11593	MK-2206 (hydrochloride) ≥98%	1032350-13-2	25mg	$151	2026-04-30	Buy
Biosynth	FA26026	MK 2206 dihydrochloride	1032350-13-2	50mg	$317	2026-06-04	Buy

Product number	Packaging	Price	Buy
11593	1mg	$48	Buy
11593	5mg	$94	Buy
11593	10mg	$117	Buy
11593	25mg	$151	Buy
FA26026	50mg	$317	Buy

MK-2206 2HCl Chemical Properties,Uses,Production

Description

MK-2206 (CAS 1032350-13-2) is a potent and selective allosteric inhibitor of Akt (IC50’s: Akt1 = 5 nM, Akt2 = 12 nM, Akt3 = 65 nM) that enhances thein vitroandin vivoantitumor efficacy of several standard chemotherapeutic agents.1It was able to decrease insulin-stimulated glucose uptake, glycogen synthesis and glycogen synthase activity in rat muscle.2MK-2206 induced G1-phase cycle arrest and sensitized HepG2 hepatocellular carcinoma cells to TRAIL-induced apoptosis.3

Uses

A highly selective inhibitor of Akt. Akt1, IC50=8 nM; Akt2, IC50=12 nM; Akt3, IC50=65 nM.

Uses

AZD 6244 and MK 2206 are targeted small-molecule drugs that inhibit MEK and AKT responses. The combination of AZD6244 and MK2206 has a significant synergistic effect on tumor growth in vitro and in vivo and leads to increased survival rates in mice bearing highly aggressive human lung tumors. Antitumor agents. Potent AKT inhibitor.

in vivo

Both MK-2206 dihydrochloride (MK-2206 (2HCl)) doses (oral gavage; 480 mg/kg once a week and 240 mg/kg three times a week; for 2 weeks) can inhibit the growth of human CNE-2 xenografts in nude mice. No other obvious toxicity is observed in mice^[2].
MK-2206 dihydrochloride (orally; 120 mg/kg; alternate days; for 3 weeks) significantly inhibits tumor growth in 3-5 week old athymic nude mice with GEO colon carcinoma cells^[3].

Animal Model:	Four- to 6-week-old male BALB/c nude mice with CNE-2 xenografts^[2]
Dosage:	240 mg/kg and 480 mg/kg
Administration:	Oral gavage; 240 mg/kg for three times a week; 480 mg/kg for once a week; for 2 weeks
Result:	Both doses inhibited the growth of human CNE-2 xenografts in nude mice.

target

Akt1

IC 50

Akt1: 8 nM (IC₅₀); Akt2: 12 nM (IC₅₀); Akt3: 65 nM (IC₅₀)

storage

-20°C

References

[1] HIROSHI HIRAI. MK-2206, an allosteric Akt inhibitor, enhances antitumor efficacy by standard chemotherapeutic agents or molecular targeted drugs in vitro and in vivo.[J]. Molecular Cancer Therapeutics, 2010, 9 7: 1956-1967. DOI:10.1158/1535-7163.mct-09-1012
[2] YU-CHIANG LAI. A novel PKB/Akt inhibitor, MK-2206, effectively inhibits insulin-stimulated glucose metabolism and protein synthesis in isolated rat skeletal muscle.[J]. Biochemical Journal, 2012, 447 1: 137-147. DOI:10.1042/bj20120772
[3] PENG JIAO. MK-2206 induces cell cycle arrest and apoptosis in HepG2 cells and sensitizes TRAIL-mediated cell death.[J]. Molecular and Cellular Biochemistry, 2013, 382 1-2: 217-224. DOI:10.1007/s11010-013-1737-0

MK-2206 2HCl Preparation Products And Raw materials

Raw materials

Preparation Products

MK-2206 2HCl Suppliers

Global( 268)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Xianning Shen Lan Biomedical Research and Development Co., Ltd.	18171815831	1341138380@qq.com	China	4572	58
TargetMol Chemicals Inc.	021-021-33632979 15002134094	marketing@targetmol.com	China	7993	58
Wuhan Augda Biotechnology Co., Ltd	15071299552	262933239@qq.com	China	7200	58
Shanghai jerryxing Biomedical Technology Co., Ltd	17521512546 17721492509	460170712@qq.com	China	4965	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2915	55
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Chembest Research Laboratories Limited	021-20908456	sales@BioChemBest.com	China	5996	61
Shangchem Co., Ltd.	+86-21-68182121		China	881	52
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	17702719238	sales@sun-shinechem.com	China	1197	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50

Supplier	Advantage
Xianning Shen Lan Biomedical Research and Development Co., Ltd.	58
TargetMol Chemicals Inc.	58
Wuhan Augda Biotechnology Co., Ltd	58
Shanghai jerryxing Biomedical Technology Co., Ltd	58
Shanghai Boyle Chemical Co., Ltd.	55
J & K SCIENTIFIC LTD.	76
Chembest Research Laboratories Limited	61
Shangchem Co., Ltd.	52
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50

View Lastest Price from MK-2206 2HCl manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-20	MK-2206 dihydrochloride 1032350-13-2	$30.00-64.00		99.73%	10g	TargetMol Chemicals Inc.
2023-09-07	MK-2206 2HCl 1032350-13-2	$30.00	1kg	99%	1000t/year	Anhui Ruihan Technology Co., Ltd
2019-07-06	MK-2206 2HCl 1032350-13-2	$2.00	1kg	99%	100kg	Career Henan Chemical Co

MK-2206 dihydrochloride
1032350-13-2
$30.00-64.00
99.73%
TargetMol Chemicals Inc.

MK-2206 2HCl
1032350-13-2
$30.00
99%
Anhui Ruihan Technology Co., Ltd

MK-2206 2HCl
1032350-13-2
$2.00
99%
Career Henan Chemical Co

MK-2206 2HCl Spectrum

MK-2206 2HCl(1032350-13-2)¹HNMR

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1of4

8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride MK 2206 2HCL;MK2206 2HCL CS-260 MK2206; MK-2206; MK 2206; MK2206 DIHYDROCHLORIDE; MK2206 HCL. 8-[4-(1-AMinocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one Hydrochloride 8-(4-(1-aminocyclobutyl)phenyl)-9-phenyl-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3(2H)-one 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride MK-2206 MK-2206 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochloride MK 2206 (hydrochloride) MK-2206 2HCl MK-2206 dihydrochloride, >=98% MK-2206 2HCL;MK2206 8-[4-(1-Aminocyclobutyl)phenyl]-9-phenyl-1,2,4-triazolo[3,4-f][1,6]naphthyridin-3(2H)-one dihydrochlorideMK-2206 Dihydrochloride MK-2206 HCl salt 1,2,4-Triazolo[3,4-f][1,6]naphthyridin-3(2H)-one, 8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-, hydrochloride (1:2) (8-[4-(1-aminocyclobutyl)phenyl]-9-phenyl-2H-[1,2,4]triazolo[3,4-f][1,6]naphthyridin-3-one) dihydrochloride MK 2206 dihydrochloride, 98%, an allosteric Akt inhibitor 8-[4-(1-AMINOCYCLOBUTYL)PHENYL]-9-PHENYL-1,2,4-TRIAZOLO[3,4-F][1,6]NAPHTHYRIDIN-3(2H)-ONE 2HCL MK 2206 2HCL;MK2206 2HCL;MK-2206 DIHYDROCHLORIDE;MK2206 DIHYDROCHLORIDE MK-2206 2HCl USP/EP/BP MK-2206 2HCl/MK-2206 dihydrochloride MK-2206 dihydrochloride MK2206 MK-2206 DIHYDROCHLORIDE SALT (2XHCL SALT) Benodanil Impurity 9 MK-2206 dihydrochloride, 10 mM in DMSO MK-2206 2HCl ，S1078 MK-2206 MK-2206 Dihydrochloride 1032350-13-2 C25H21N5O2HCl C25H23Cl2N5O C25H21N5O2ClH Inhibitor PI3K/Akt/mTOR Inhibitors Akt mTOR PI3K Amines Heterocycles Intermediates & Fine Chemicals Pharmaceuticals