ChemicalBook >> CAS DataBase List >>N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine structure

CAS No.: 81256-88-4

Chemical Name:: N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

Synonyms: 5'-DMT-4'-TBDMS-Bz-rA;5'-DMT-3'-TBDMS-Bz-rA;5'-O-DMT-3'-O-TBDMS-Bz-rA;N6-benzoyl-5'-O-DMT-3'-O-TBDM;N6-benzoyl-5'-O-DMT-3'-O-TBDMS-adenosine;5'-O-DMT-3'-O-TBDMS-N6-Benzoyl-Adenosine;N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine;5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-N6-benzoyl-Adenosine;N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine;Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]-

CBNumber:: CB52630871

Molecular Formula:: C44H49N5O7Si

Molecular Weight:: 787.98

MDL Number:: MFCD00274103

MOL File:: 81256-88-4.mol

MSDS File:: SDS

Last updated:2026-07-28 08:09:34

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N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Properties

Density	1.232±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp.	2-8°C
solubility	DMSO : 100 mg/mL (126.91 mM)
pka	7.871±0.43(predicted)
form	Solid
color	White to off-white

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H332-H335
Precautionary statements	P261-P280-P305+P351+P338

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine price More Price(43)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	295511	N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine Asreported	81256-88-4	2g	$1351	2026-06-03	Buy
Usbiological	295511	N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine Asreported	81256-88-4	5g	$2088	2026-06-03	Buy
Usbiological	295511	N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine Asreported	81256-88-4	10g	$3575	2026-06-03	Buy
Usbiological	295511	N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine Asreported	81256-88-4	25g	$6476	2026-06-03	Buy
Usbiological	295511	N6-Benzoyl-3'-O-tert-butyldimethylsilyl-5'-O-DMT-adenosine Asreported	81256-88-4	50g	$11148	2026-06-03	Buy

Product number	Packaging	Price	Buy
295511	2g	$1351	Buy
295511	5g	$2088	Buy
295511	10g	$3575	Buy
295511	25g	$6476	Buy
295511	50g	$11148	Buy

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Chemical Properties, Uses, Production

Uses

5'-DMT-3'-TBDMS-Bz-rA is a nucleoside with protective and modification effects.

Synthesis

Benzamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-α-D-ribofuranosyl]-9H-purin-6-yl]-

129666-75-7

18162-48-6

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine

81256-88-4

Benzamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-2-O-[(1,1-dimethylethyl)dimethylsilyl]-α-D-ribofuranosyl]-9H-purin-6-yl]-

129681-71-6

Synthesis of N-(9-((2R,3R,4S,5R)-5-((bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide ( CAS:129681-71-6) was prepared in the following general procedure: to a mixed solution of tetrahydrofuran (THF, 800 mL) and pyridine (15 mL) of the product of the previous step (200 g, 296.9 mmol) was added, in sequence, silver cyanide (AgNCb, 83.2 g, 489.8 mmol, 1.65 eq.) and tert-butyldimethylchlorosilane ( TBSCl, 78.7 g, 522.5 mmol, 1.76 equiv). The reaction mixture was stirred at room temperature for 16 hours. After completion of the reaction, the mixture was filtered, diluted with water (H2O, 1.0 L) and extracted with ethyl acetate (EtOAc, 3 x 1.0 L). The organic layers were combined, washed with brine (2 × 1.0 L), dried over anhydrous sodium sulfate (Na2SO4) and concentrated under reduced pressure. The residue was purified by silica gel (SiO2) column chromatography with petroleum ether/ethyl acetate (3:1 to 1:1) as eluent to give the products D-2a (114 g, 145 mmol, 49% yield) and D-2b (53 g, 68 mmol, 23% yield).

References

[1] Patent: WO2018/156625, 2018, A1. Location in patent: Paragraph 0296
[2] Canadian Journal of Chemistry, 1982, vol. 60, p. 111 - 120

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Preparation Products And Raw materials

Raw materials

Benzamide, N-[9-[5-O-[bis(4-methoxyphenyl)phenylmethyl]-α-D-ribofuranosyl]-9H-purin-6-yl]- tert-Butyldimethylsilyl chloride Silver nitrate Tetrahydrofuran Pyridine

Preparation Products

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Suppliers

Global Suppliers ( 59)

Supplier	Tel	Email	Country	ProdList	Advantage
Nanjing Baifuli Technology Co., Ltd.	25-25-58740604 15951658055	sales@unisyn.cn	China	622	58
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Cool Pharm, Ltd	021-60455363 18019463053	sales@coolpharm.com	China	8455	58
Wuhu Nuowei Chemical Technology Co., Ltd	0553-8233716 18055326116	sales@nuowei-chem.com	China	742	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.	027-50664929, 13971561712	hubxys2001@163.com	China	1436	55
Aikon International Limited	025-66061636 19370895928	qqyang@aikonchem.com	China	15810	58
Wuhu Huaren Science and Technology Co., Ltd.	5842013 18155347026	xujuan@hdpharm.com	China	547	58
Maanshan geneyan biotech Co.,LTD	18913822354	market@geneyan-bio.com	China	299	58
Shanghai Jizhi Biochemical Technology Co. Ltd.	021-4009004166/18616739031 18616739031	3007523370@qq.com	China	40000	58

Supplier	Advantage
Nanjing Baifuli Technology Co., Ltd.	58
Bide Pharmatech Ltd.	60
Cool Pharm, Ltd	58
Wuhu Nuowei Chemical Technology Co., Ltd	55
Amadis Chemical Company Limited	58
Hubei Xinyuanshun Pharmaceutical Chemical Co., Ltd.	55
Aikon International Limited	58
Wuhu Huaren Science and Technology Co., Ltd.	58
Maanshan geneyan biotech Co.,LTD	58
Shanghai Jizhi Biochemical Technology Co. Ltd.	58

View Latest Price from N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-08-13	5'-DMT-3'-TBDMS-Bz-rA 81256-88-4		1G	98%	2000	Shenzhen Nexcon Pharmatechs Ltd.
	2025-07-18	5'-DMT-3'-TBDMS-Bz-rA 81256-88-4	$42.00			10g	TargetMol Chemicals Inc.

5'-DMT-3'-TBDMS-Bz-rA
81256-88-4
98%
Shenzhen Nexcon Pharmatechs Ltd.

5'-DMT-3'-TBDMS-Bz-rA
81256-88-4
$42.00
TargetMol Chemicals Inc.

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine Spectrum

N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine(81256-88-4)¹HNMR

81256-88-4 (N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine) Related Search:

5'-DMT-ribo adenosine (N-Bz) o-Phenetidine Ceteareth-5 Sodium levothyroxine 2,2-Diphenylacetic acid

5'-O-DMTr-N2-isobutyrylguanosine 5'-O-DMT-2'-O-TBDMS-N-Bz-Adenosine N2-isobutyryl-5'-O-(4,4'-dimethoxytrityl)-3'-O-tert-butyldimethylsilyl guanosine 5'-O-DMT-2'-O-iBu-N-Bz-Guanosine

1of2

N6-benzoyl-5'-O-DMT-3'-O-TBDMS-adenosine N6-benzoyl-3'-O-t-butyldiMethylsilyl-5'-O-(4,4'-diMethoxytrityl)-adenosine 5'-DMT-3'-TBDMS-Bz-rA Adenosine, N-benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethyl ethyl)dimethylsilyl]- 5'-DMT-4'-TBDMS-Bz-rA N-Benzoyl-5'-O-[bis(4-methoxyphenyl)phenylmethyl]-3'-O-[(1,1-dimethylethyl)dimethylsilyl]adenosine N6-benzoyl-5'-O-DMT-3'-O-TBDM 5'-O-DMT-3'-O-TBDMS-Bz-rA 5'-O-(4,4'-dimethoxytrityl)-3'-O-(t-butyl-dimethylsilyl)-N6-benzoyl-Adenosine 5'-O-DMT-3'-O-TBDMS-N6-Benzoyl-Adenosine N-(9-((2R,3R,4S,5R)-5-((Bis(4-methoxyphenyl)(phenyl)methoxy)methyl)-4-((tert-butyldimethylsilyl)oxy)-3-hydroxytetrahydrofuran-2-yl)-9H-purin-6-yl)benzamide N-[9-[(2R,3R,4S,5R)-5-[[Bis(4-methoxyphenyl)(phenyl)methoxy]methyl]-4-[(tert-butyldimethylsilyl)oxy]-3-hydroxytetrahydro-2-furyl]-9H-6-purinly]benzamide 81256-88-4