ChemicalBook >> CAS DataBase List >>1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone structure

CAS No.: 1267610-26-3

Chemical Name:: 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone

Synonyms: 1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one;Apixaban intA;Apixaban Impurity S;Apixaban Impurity 50;Apixaban Impurity 47;Apixaba inretMediate A;Apixaban related impurities 2;4-Pyrimidinol,2-methoxy-12-methyl-;1-(4-aminophenyl)-5,6-dihydro-3-(4-;1-(4-Aminophenyl)-5,6-Dihydro-3-(4-Morpholinyl)-2(1H)-Py

CBNumber:: CB52660744

Molecular Formula:: C15H19N3O2

Molecular Weight:: 273.33

MDL Number:: MFCD22581648

MOL File:: 1267610-26-3.mol

MSDS File:: SDS

Last updated:2026-07-16 07:06:08

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1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Properties

Melting point	>246°C (dec.)
Boiling point	491.5±45.0 °C(Predicted)
Density	1.277±0.06 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	4.96±0.10(Predicted)
color	Off-White to Pale Beige
InChI	InChI=1S/C15H19N3O2/c16-12-3-5-13(6-4-12)18-7-1-2-14(15(18)19)17-8-10-20-11-9-17/h2-6H,1,7-11,16H2
InChIKey	YUGIGSPFTMLIMA-UHFFFAOYSA-N
SMILES	C1(=O)N(C2=CC=C(N)C=C2)CCC=C1N1CCOCC1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338
REACH Registrations	Active

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Synthonix	A58339	1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 95+%	1267610-26-3	5g	$25	2026-05-06	Buy
Synthonix	A58339	1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 95+%	1267610-26-3	10g	$40	2026-05-06	Buy
Synthonix	A58339	1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 95+%	1267610-26-3	25g	$60	2026-05-06	Buy
Synthonix	A58339	1-(4-Aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one 95+%	1267610-26-3	100g	$230	2026-05-06	Buy
ACHEMBLOCK	W169004	1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridinone 95%	1267610-26-3	250G	$290	2026-05-27	Buy

Product number	Packaging	Price	Buy
A58339	5g	$25	Buy
A58339	10g	$40	Buy
A58339	25g	$60	Buy
A58339	100g	$230	Buy
W169004	250G	$290	Buy

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Chemical Properties, Uses, Production

Uses

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone is an intermediate in the synthesis of Apixaban (A726700), A potent, direct, selective, and orally active inhibitor of coagulation factor Xa. It is a potential new oral coagulant that may be useful prevention of venous thromboembolism in total hip, knee replacement orthopedic surgery and stroke in treatment of patient with venous thromboembolic disorder or with atrial fibrillation.

Synthesis

Synthesis_1267610-26-3
Add 25L of water and 25L of methanol to the 500L reactor, add 2.5kg of compound (I) and 250g of Raney cobalt under stirring, raise the temperature to 40-50 C, slowly add 2.0kg of hydrazine hydrate (content 80%), keep warm 60-70 C, reaction for 3h, the reaction was completed, filtered with diatomaceous earth, concentrated solvent was removed, and MTBE was added to the filter cake.2.20 kg of a white solid were obtained with a yield of 98% and a purity of 99.8%.

Synthesis

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in laboratory research and development processes and chemical production In the process.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone synthesis

Synthesis of 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone from 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Preparation Products And Raw materials

Raw materials

Preparation Products

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Suppliers

Global Suppliers ( 291)

Supplier	Tel	Email	Country	ProdList	Advantage
Jinan Jianfeng Chemical Co., Ltd.	0531-88110457; 18954159893	demi@pharmachemm.com	China	205	58
Jiangsu Vcare PharmaTech Co., Ltd.	025-58741518 13327700685	sales@vcarepharmatech.com	China	281	61
Shandong kelikang drug co., ltd	053-88113608 17854192669	sales07@pharmachemm.com	China	149	58
Jinan Billion Pharmaceutical Technology Co., Ltd	+86-15589952515	80912934@qq.com	China	57	58
Hefei Topway Biotechnology Co.,Ltd	0551-65326752 14755135869	xxhasym@163.com	China	47	60
Shandong Jianfeng Chemical Co.,Ltd.	0531-0531-88110457 18954159739	demi@pharmachemm.com	China	108	58
Jinan zhongdaoanran chemical Co;Ltd	18678233466; 18678233466	122574856@qq.com	China	199	58
Suzhou lipin Chemical Co., Ltd	0512-67509664 19888480046	3516936381@qq.com	China	111	58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD	0755-83725350 13380397412	3001280422@qq.com	China	10000	58
ChemFuture PharmaTech (Jiangsu) Ltd	5108538618	suger.wang@chemfuture.com	China	832	65

Supplier	Advantage
Jinan Jianfeng Chemical Co., Ltd.	58
Jiangsu Vcare PharmaTech Co., Ltd.	61
Shandong kelikang drug co., ltd	58
Jinan Billion Pharmaceutical Technology Co., Ltd	58
Hefei Topway Biotechnology Co.,Ltd	60
Shandong Jianfeng Chemical Co.,Ltd.	58
Jinan zhongdaoanran chemical Co;Ltd	58
Suzhou lipin Chemical Co., Ltd	58
SHENZHEN PHYSTANDARD BIO-TECH CO.,LTD	58
ChemFuture PharmaTech (Jiangsu) Ltd	65

View Latest Price from 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3	$2.00	1kg	99%	1200KG/M	Jinan Million Pharmaceutical Co., Ltd
2026-09-18	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3	$25.00	1KG	98%	20 tons	Speranza Chemical Co., Ltd.
2026-07-15	1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1267610-26-3			98.26%	10g	TargetMol Chemicals Inc.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
1267610-26-3
$2.00
99%
Jinan Million Pharmaceutical Co., Ltd

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
1267610-26-3
$25.00
98%
Speranza Chemical Co., Ltd.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone
1267610-26-3
$0.00
98.26%
TargetMol Chemicals Inc.

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone Spectrum

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone(1267610-26-3)¹HNMR

1267610-26-3 (1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone) Related Search:

Apixaban Impurity BMS-591329 Apixaban Apixaban Impurity 16 Apixaban IMpurity 2 Apixaban IMpurity 3

1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide ethyl 1-(4-methoxyphenyl)-6-(4-nitrophenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate Apixaban Impurity 11 Apixaban IMpurity(BMS-591329-01) Ethyl (2Z)-chloro[(4-methoxyphenyl)hydrazono]ethanoate

ethyl 6-(4-aMinophenyl)-1-(4-Methoxyphenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylate 3-Chloro-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one 3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one

1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone 1-(4-Iodo-phenyl)-piperidin-2-one

1of4

1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 2(1H)-Pyridinone, 1-(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)- Apixaba inretMediate A Apixaban Impurity S Apixaban Impurity 47 Apixaban intA Apixaban related impurities 2 Apixaban Impurity 50 ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，1-(4-AMinophenyl)-5,6-dihydro-3-(4- Morpholinyl)-2(1h)-pyridinone -(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridi... 2(1H)-Pyridinone,1-Chemicalbook(4-aMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)- 1-(4-aminophenyl)-5,6-dihydro-3-(4- 4-Pyrimidinol,2-methoxy-12-methyl- 1-(4-Aminophenyl)-5-Morpholin-4-yl-2,3-Dihydropyridin-6-One 5.6-Dihydro-3-(4-morpholinyl)-1-(4-aminophenyl)-2(1H)-pyridinone 1-(4-Aminophenyl)-3-(4-morpholinyl)-5,6-dihydro-2(1H)-pyridinone 1-(4-Amino Phenyl)-5,6-Dihydro-3-Morpholino-Pyridin-2(1H)-one 1-(4-aminophenyl)-5, 6-dihydro-3 -(4-morpholine)-2(1H) -pyridone 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholinyl)-2(1H)-pyridone 1-(4-Aminophenyl)-5,6-Dihydro-3-(4-Morpholinyl)-2(1H)-Py 1-(4-Amino-phenyl)-3-morpholin-4-yl-5,6-dihydro-1H-pyridin-2-one 1-(4-Aminophenyl)-3-(morpholin-4-yl)-5,6-dihydropyridin-2(1H)-one 1-(4-aminophenyl)-3-morpholino-5,6-dihydropyridin-2(1H)-one (Intermediate of Apixaban) 3-(4-Morpholinyl)-2(1h)-pyridinone-1-(4-AMinophenyl) -5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-aMinophenyl)-3-Morpholino-5,6-dihydropyridin-2(1H)-one 1-(4-Aminophenyl)-5,6-dihydro-3-(4-morpholino)pyridin-2(1H)-one 1-(4-Aminophenyl)-5,6-dihydro-3-(morpholin-4-yl)pyridin-2(1H)-one 1267610-26-3 267610-26-3