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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Structure
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate structure
CAS No.
27143-07-3
Chemical Name:
Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate
Synonyms
Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate;(Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Apixaban Impurity B;Apixaban Impurity 2;Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate;Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester;Apixaban-2;hydrazono);Ethyl chloro
CBNumber:
CB92500866
Molecular Formula:
C11H13ClN2O3
Molecular Weight:
256.69
MDL Number:
MFCD02852962
MOL File:
27143-07-3.mol
MSDS File:
SDS
Last updated:2026-05-28 05:28:28
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Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Properties

Melting point 94℃
Boiling point 349.0±44.0 °C(Predicted)
Density 1.23
storage temp. 2-8°C
solubility Chloroform (Sparingly), Methanol (Slightly)
form Solid
pka 11.63±0.10(Predicted)
color Yellow to Dark Yellow
InChI InChI=1S/C11H13ClN2O3/c1-3-17-11(15)10(12)14-13-8-4-6-9(16-2)7-5-8/h4-7,13H,3H2,1-2H3
InChIKey ATNPZEGMKLGIFA-UHFFFAOYSA-N
SMILES C(OCC)(=O)C(Cl)=NNC1=CC=C(OC)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H315
Precautionary statements  P264-P280-P302+P352-P321-P332+P313-P362

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate price More Price(71)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Usbiological 275920 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Asreported 27143-07-3 10g $319 2026-06-03 Buy
Usbiological 275920 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Asreported 27143-07-3 25g $453 2026-06-03 Buy
Usbiological 275920 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Asreported 27143-07-3 50g $602 2026-06-03 Buy
Usbiological 275920 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Asreported 27143-07-3 100g $799 2026-06-03 Buy
Usbiological 275920 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Asreported 27143-07-3 250g $1200 2026-06-03 Buy
Product number Packaging Price Buy
275920 10g $319 Buy
275920 25g $453 Buy
275920 50g $602 Buy
275920 100g $799 Buy
275920 250g $1200 Buy

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Chemical Properties, Uses, Production

Physical properties

Light yellow to dark yellow solid

Uses

Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester is an ester derivative and can be used as an intermediate in the synthesis of apixaban.

Synthesis

Step-1:Water (600 ml) was added to p-anisidine (100 g) at room temperature and the resulting mixture was cooled to 10°C, followed by the addition of concentrated hydrochloric acid (133.5 g). The resulting mixture was cooled to —5°C to 0°C, followed by portion-wise addition of 40 % aqueous sodium nitrite solution over 45 minutes to 1 hour. The resulting mass was stirred for 1 hour 30 minutes at —5°C to0°C, followed by slow addition of 11 % sulfamic acid solution over 1 hour to 1 hour 30 minutes to produce a reaction mass (first part).Step-2:Sodium acetate (146 g) was added to water (300 ml) at room temperature and then stirred for 10 minutes to 15 minutes, followed by the addition of ethyl 2-chloroacetoacetate (160.4g) and acetone (300 ml) at room temperature to form a reaction mixture. The resulting mixture was cooled to 0°C. The resulting mixture was added to the reaction mass (first part) obtained in step-i at —5°C to 0°C and then stirred for 1 hour at the same temperature. Acetone (200 ml) was added to the resulting mass and stirred for 30 minutes at —5°C to 0°C. The resulting mass was settled for 5 hours at —5°C to 0°Cand then filtered the solid. Methanol (150 ml) was added to the resulting solid at room temperature and then stirred for 2 hours at the same temperature. Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazone)acetate was obtained through further purity.

References

[1] Patent: CN104513239, 2017, B. Location in patent: Paragraph 0197; 0238; 0243; 0244
[2] European Journal of Medicinal Chemistry, 2016, vol. 123, p. 431 - 446
[3] Patent: CN107400131, 2017, A. Location in patent: Paragraph 0026; 0031; 0042-0044
[4] Patent: CN105384739, 2016, A. Location in patent: Paragraph 0391; 0392; 0393
[5] Patent: CN104395312, 2016, B. Location in patent: Paragraph 0396; 0451-0455; 0501; 0502-0506

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate synthesis

104-94-9
609-15-4
27143-07-3
Synthesis of Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate from p-Anisidine and Ethyl 2-chloroacetoacetate

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Preparation Products And Raw materials

Raw materials

p-Anisidine Ethyl 4-chloroacetoacetate Ethyl 2-chloroacetoacetate Sodium acetate Hydrochloric acid
Sodium nitrite

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Preparation Products

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Suppliers

Global Suppliers ( 496)
Supplier Tel Email Country ProdList Advantage
Jinan Jianfeng Chemical Co., Ltd. 0531-88110457; 18954159893 demi@pharmachemm.com China 205 58
Jiangsu Vcare PharmaTech Co., Ltd. 025-58741518 13327700685 sales@vcarepharmatech.com China 281 61
ChemFuture PharmaTech (Jiangsu) Ltd 5108538618 suger.wang@chemfuture.com China 832 65
Shandong kelikang drug co., ltd 053-88113608 17854192669 sales07@pharmachemm.com China 149 58
Anhui Cheer-Our Medical technology Co.,Ltd 63535381 13485700777 gaylen@cheer-our.com China 101 58
Jilin Lianben Technology Development Co., Ltd China 46 58
Jinan zhongdaoanran chemical Co;Ltd 18678233466; 18678233466 122574856@qq.com China 199 58
ShangHai DEMO Chemical Co.,Ltd 400-021-7337 2355568890 sales@demochem.com China 2569 57
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 0311-89250318 13582355795 master@sjzsdyn.com China 2776 65
Adamas Reagent, Ltd. 400-6009262 15618770481 yhx@titansci.com China 14098 59
Supplier Advantage
Jinan Jianfeng Chemical Co., Ltd. 58
Jiangsu Vcare PharmaTech Co., Ltd. 61
ChemFuture PharmaTech (Jiangsu) Ltd 65
Shandong kelikang drug co., ltd 58
Anhui Cheer-Our Medical technology Co.,Ltd 58
Jilin Lianben Technology Development Co., Ltd 58
Jinan zhongdaoanran chemical Co;Ltd 58
ShangHai DEMO Chemical Co.,Ltd 57
Shijiazhuang Sdyano Fine Chemical Co., Ltd. 65
Adamas Reagent, Ltd. 59

View Latest Price from Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate pictures 2026-09-20 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate
27143-07-3
 $20.00 1KG 98% 20 tons Speranza Chemical Co., Ltd.
Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester pictures 2026-09-20 Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester
27143-07-3
 0.99 RongNa Biotechnology Co.,Ltd
Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate pictures 2026-09-20 Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate
27143-07-3
 $12.00 1KG 99% 200mt/year Jinan Finer Chemical Co., Ltd

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate Spectrum

Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate(27143-07-3)1HNMR

27143-07-3 (Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate) Related Search:

Apixaban Impurity 20 (4,4'‐didodecyl‐2,2'‐ bithiophene‐5,5'‐ diyl)bis(triMethylstann ane) 1-(4-Methoxyphenyl)-6-(4-(2-Methyl-6-oxopiperidin-1-yl)phenyl)-7-oxo-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Impurity 13 1-(4-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid
Apixaban IMpurity 3 1-(4-chlorophenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxaMide Apixaban Impurity 11 Apixaban IMpurity 5 (BMS-591329-01) 3-Morpholino-1-(4-(2-oxopiperidin-1-yl)phenyl)-5,6-dihydropyridin-2(1H)-one
3-Morpholino-1-(4-nitrophenyl)-5,6-dihydropyridin-2(1H)-one 1-(4-AMinophenyl)-5,6-dihydro-3-(4-Morpholinyl)-2(1h)-pyridinone 1-(4-Methoxyphenyl)-7-oxo-6-[4-(2-oxopiperidin-1-yl)phenyl]-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxylic acid ethyl ester 1-(4-Nitrophenyl)-2-piperidinone 4,5,6,7-Tetrahydro-1-(4-methoxyphenyl)-6-[4-(5-methyl-2-oxo-1-piperidinyl)phenyl]-7-oxo-1H-pyrazolo[3,4-c]pyridine-3-carboxamide
(S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl (R)-3-Piperidinamine dihydrochloride Ethyl (2E)-chloro[(4-chlorophenyl)hydrazono]acetate

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2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate (Z)-Ethyl 2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Apixaban) Apixaban-2 1-(4-methoxyphenyl)-4-(2-((4-(2-oxopiperidin-1-yl)phenyl)amino)ethyl)-1H-pyrazole-3,5-dicarboxamide Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester (Z)- Ethyl chloro[(4-Methoxyphenyl)hydrazono]acetate Ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl ester 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene], ethyl ester ethyl chloro[2-(4-Methoxyphenyl)hydrazinylidene]acetate thyl chloro[2-(4-methoxyphenyl)hydrazinylidene]acetate Chloro((4-Methoxyphenyl)hydrazone)acetic acid ethyl ester 1. 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene]acetic acid ethyl ester 2-chloro-2-[2-(4-Methoxyphenyl)hydrazinylidene] acetic acid, ethyl ester Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Chloro[(4-methoxyphenyl)hydrazono]acetic acid ethyl ester ethyl (2Z)-2-chloro-2-[(4-methoxyphenyl)hydrazinylidene]acetate Apixaban Intermediate 1 Ethyl 2-chloro-2-(2-(4-methoxyphenyl) hydrazono) Acetic acid, chloro[(4-methoxyphenyl)hydrazono]-, ethyl ester Apixaban intermediates，Ethyl chloro[2-(4- methoxyphenyl)hydrazinylidene]acetate ethyl 7-chloro-8-methyl-4-oxo-1,4-dihydroquinoline-3-carboxylate，Aceticacid,2-chloro-2-[2-(4- methoxyphenyl)hydrazinylidene], ethyl ester Apixaban ethyl chloroacetate Apixaban Impurity 158 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene] Apixaban Impurity 18 Ethyl 2-chloro-2-(2 -(4-methoxyphenyl)hydrazono)acetate chloro ester Impurity of apixaban382 ethyl 2-chloro-2-[(4-methoxyphenyl)hydrazono]acetate Acetic acid, 2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene], ethyl este Aceticacid,2-chloro-2-[2-(4-methoxyphenyl)hydrazinylidene]-,ethylester,(8Z)- RSYY（Avanafil)-38 RSYY（Avanafil)-43 Ethyl [(4-methoxyphenyl)hydrazono]chloroacetate Ethyl chloro (Z)-Ethyl-2-C-2-(2-(4-Methoxy Phenyl) Hydrazone acetate Ethyl chloro[(4-methoxyphenyl)hydrazono]acetat Ethyl 2-chloro-2-[2-(4-methyoxyphenyl)hydrazono]acetate Ethyl[(4-methoxyphenyl)hydrazino]chloroacetate (4-methoxyphenyl) hydrazino] chloroacetic acid ethyl ester Ethyl 2-chloro-2-[2-(4-methoxyphenyl)hydrazineylidene]acetate ETHYL 2-CHLORO-2-(2-(4-METHOXYPHENYL)HYDRAZONO)ACETATE 99% Ethyl-2-chloro-2-(2-(4-methoxyphenyl)hydrazono)acetate (Intermediate of Apixaban) 2-chloro-2-[2-(4-methoxyphenyl)isohydrazineyl]acetic acidethyl ester Apixaban Impurity 27 (Mixture of Z and E Isomers) Apixaban Impurity 18(Z/Emixture) (Z)-ethyl 2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate (4-Methoxyphenyl)hydrazino]chloroacetic acid ethyl ester(Apixaban Intermediate) Apixaban Impurity B Apixaban Impurity 2 Ethyl(z)-2-chloro-2-(2-(4-Methoxyphenyl)hydrazono)acetate Ethyl chloro[(4-methoxyphenyl)hydrazono]acetate Apixaban Related Impurity 1-(2-methoxyphenyl)-7-oxo-6-(4-(2-oxopiperidin-1-yl)phenyl)-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-c]pyridine-3-carboxamide 27143-07-3 27143-07-0 27143-07-2 27143-07-9 27143-07-3