Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Structure
tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate structure
CAS No.
558442-96-9
Chemical Name:
tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate
Synonyms
105471;tert-butyl N-(4-morpholinocyclohexyl)carbamate;tert-Butyl (trans-4-morpholinocyclohexyl)carbamate;tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate;(trans-4-morpholinecyclohexyl)aminomacetic acidtertbutyl ester;Carbamic acid, N-[trans-4-(4-morpholinyl)cyclohexyl]-, 1,1-dimethylethyl ester
CBNumber:
CB52684445
Molecular Formula:
C15H28N2O3
Molecular Weight:
284.4
MDL Number:
MFCD27978480
MOL File:
558442-96-9.mol
MSDS File:
SDS
Last updated:2026-05-28 04:58:09
Request For Quotation

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Properties

Boiling point 396.3±37.0 °C(Predicted)
Density 1.07±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka 12.50±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P280-P305+P351+P338

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Matrix Scientific 120887 tert-Butyl ((1r,4r)-4-morpholinocyclohexyl)-carbamate 558442-96-9 5.00g $1486 2026-05-18 Buy
Matrix Scientific 120887 tert-Butyl ((1r,4r)-4-morpholinocyclohexyl)-carbamate 558442-96-9 10.00g $2376 2026-05-18 Buy
aablocks AA00E89W tert-Butyl (trans-4-morpholinocyclohexyl)carbamate 95% 558442-96-9 100mg $127 2026-05-28 Buy
aablocks AA00E89W tert-Butyl (trans-4-morpholinocyclohexyl)carbamate 95% 558442-96-9 250mg $173 2026-05-28 Buy
aablocks AA00E89W tert-Butyl (trans-4-morpholinocyclohexyl)carbamate 95% 558442-96-9 1g $467 2026-05-28 Buy
Product number Packaging Price Buy
120887 5.00g $1486 Buy
120887 10.00g $2376 Buy
AA00E89W 100mg $127 Buy
AA00E89W 250mg $173 Buy
AA00E89W 1g $467 Buy

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Chemical Properties, Uses, Production

Synthesis

2,2'-Dibromodiethyl ether

5414-19-7

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE

177906-48-8

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate

558442-96-9

The general procedure for the synthesis of tert-butyl (trans-4-morpholinocyclohexyl)carbamate from 2,2'-dibromodiethyl ether and tert-butyl trans-(4-aminocyclohexyl)carbamate was as follows: 21.43 g (0.1 mol) of tert-butyl N-(trans-4-aminocyclohexyl)carbamate was dissolved into 250 mL of N,N-dimethylformamide, followed by addition of 16.76 mL (0.12 mol) bis(2-bromoethyl) ether and 34.85 mL (0.25 mol) triethylamine. The reaction mixture was stirred at 70°C for 6 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure. The residue was dissolved in ethyl acetate, and the organic layer was washed sequentially with aqueous sodium carbonate and saturated brine solution, and then dried over anhydrous sodium sulfate. The solvent was again removed by reduced pressure distillation and the residue was purified by silica gel column chromatography (elution gradient: from pure chloroform to chloroform/methanol=30/1) to give 19.92 g (70% yield) of tert-butyl (trans-4-morpholino cyclohexyl)carbamate.

References

[1] Patent: EP1775298, 2007, A1. Location in patent: Page/Page column 33-34

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate synthesis

111-44-4
177906-48-8
558442-96-9
Synthesis of tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate from 2,2'-Dichlorodiethyl ether and trans-N-Boc-1,4-cyclohexanediamine

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Preparation Products And Raw materials

Raw materials

2,2'-Dibromodiethyl ether trans-N-Boc-1,4-cyclohexanediamine Triethylamine N,N-Dimethylformamide

Preparation Products

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate Suppliers

Global Suppliers ( 28)
Supplier Tel Email Country ProdList Advantage
ChemShuttle, Inc. 0510-83588313-811 18800520310 sales@chemshuttle.com China 2999 62
Shanghai Raise Chemical Technology Co.,Ltd 15026594951 rs@raise-chem.com China 4905 55
Shanghai JiYi Biotechnology Co. Ltd. 13621943973 sales@shjiyipharmatech.com China 1166 55
Shanghai Uchem Inc. 15618758386 15618758386 sales3@myuchem.com China 1990 55
ShangHai Wisacheam Pharmaceutical Co., Ltd. 13817485796 tim@wisacheampharm.com China 3698 58
Wuxi KaideRui Pharmaceutical Technology Co., Ltd 19906241957 1557216087@qq.com China 1853 55
Wuxi AppTec 022-59987777 13552403979 jia_guoqiang@wuxiapptec.com China 22344 58
Wuxi jinluoli Pharmaceutical Technology Co., Ltd. 18021193238 534936027@qq.com China 363 58
Jiangsu aikang biomedical research and development co., LTD 025-58859352 17714375163 qzhang@aikonchem.com China 15525 58
Henan Weituxi Chemical Technology Co., Ltd. 0371-63284658 18135795563 3905209149@qq.com China 9711 58
Supplier Advantage
ChemShuttle, Inc. 62
Shanghai Raise Chemical Technology Co.,Ltd 55
Shanghai JiYi Biotechnology Co. Ltd. 55
Shanghai Uchem Inc. 55
ShangHai Wisacheam Pharmaceutical Co., Ltd. 58
Wuxi KaideRui Pharmaceutical Technology Co., Ltd 55
Wuxi AppTec 58
Wuxi jinluoli Pharmaceutical Technology Co., Ltd. 58
Jiangsu aikang biomedical research and development co., LTD 58
Henan Weituxi Chemical Technology Co., Ltd. 58

558442-96-9 (tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate) Related Search:

tert-Butyl (6-bromo-3-methylpyridin-2-yl)carbamate N-(Boc-amino)phthalimide tert-Butyl 6-iodohexylcarbamate (6-Oxo-1,6-dihydro-pyridin-3-yl)-carbaMic acid tert-butyl ester Carbamic acid, N-[(1R)-1-cyano-2-(1,1-dimethylethoxy)ethyl]-, 1,1-dimethylethyl ester
tert-Butyl (((tert-butoxycarbonyl)imino)(3,5-dimethyl-4-oxo-1,3,5-triazinan-1-yl)methyl)carbam tert-butyl 1-(2-hydroxypropyl)piperidin-4-ylcarbaMate tert-butyl (4-fluoro-4-phenylcyclohexyl)carbamate Carbamic acid, (4-ethynylphenyl)-, 1,1-dimethylethyl ester (9CI) (R)-tert-butyl (1-(1H-indol-3-yl)propan-2-yl)carbamate

1of2

tert-butyl ((1r,4r)-4-Morpholinocyclohexyl)carbaMate tert-Butyl (trans-4-morpholinocyclohexyl)carbamate 105471 Carbamic acid, N-[trans-4-(4-morpholinyl)cyclohexyl]-, 1,1-dimethylethyl ester tert-butyl N-(4-morpholinocyclohexyl)carbamate (trans-4-morpholinecyclohexyl)aminomacetic acidtertbutyl ester 558442-96-9