ChemicalBook >> CAS DataBase List >>trans-N-Boc-1,4-cyclohexanediamine

trans-N-Boc-1,4-cyclohexanediamine

trans-N-Boc-1,4-cyclohexanediamine structure

CAS No.: 177906-48-8

Chemical Name:: trans-N-Boc-1,4-cyclohexanediamine

Synonyms: N-BOC-TRANS-1,4-CYCLOHEXANEDIAMINE;N-Boc-transcyclohexanediamine;trans-4-(Boc-amino)cyclohexanamine;trans-4-(Boc-aMino)cyclohexylaMine;trans-N-Boc-1,4-cyclohexanediamine;Trans-N-Boc-cyclohexane-1,4-diamine;1-N-BOC-TRANS-1,4-CYCLOHEXYLDIAMINE;Trans-1-N-Boc-1,4-Cyclohexanediamine;Trans-1N-Boc-cyclohexane-1,4-diamine;trans-4-(Boc-amino)cyclohexylamine,97%

CBNumber:: CB1268261

Molecular Formula:: C11H22N2O2

Molecular Weight:: 214.31

MDL Number:: MFCD03001719

MOL File:: 177906-48-8.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-09-12 18:49:08

Request For Quotation

trans-N-Boc-1,4-cyclohexanediamine Properties

Boiling point	322.1±31.0 °C(Predicted)
Density	1.02±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	solid
pka	12.44±0.40(Predicted)
color	White
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-9-6-4-8(12)5-7-9/h8-9H,4-7,12H2,1-3H3,(H,13,14)/t8-,9-
InChIKey	FEYLUKDSKVSMSZ-KYZUINATSA-N
SMILES	C(OC(C)(C)C)(=O)N[C@@H]1CC[C@@H](N)CC1
CAS DataBase Reference	177906-48-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2922498590

NFPA 704

	0
2		0

trans-N-Boc-1,4-cyclohexanediamine price More Price(78)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	264006	N-Boc-trans-1,4-Cyclohexyldiamine Asreported	177906-48-8	1g	$305	2026-06-03	Buy
Usbiological	264006	N-Boc-trans-1,4-Cyclohexyldiamine Asreported	177906-48-8	2g	$403	2026-06-03	Buy
Usbiological	264006	N-Boc-trans-1,4-Cyclohexyldiamine Asreported	177906-48-8	5g	$559	2026-06-03	Buy
Usbiological	264006	N-Boc-trans-1,4-Cyclohexyldiamine Asreported	177906-48-8	10g	$744	2026-06-03	Buy
Usbiological	264006	N-Boc-trans-1,4-Cyclohexyldiamine Asreported	177906-48-8	25g	$1097	2026-06-03	Buy

Product number	Packaging	Price	Buy
264006	1g	$305	Buy
264006	2g	$403	Buy
264006	5g	$559	Buy
264006	10g	$744	Buy
264006	25g	$1097	Buy

trans-N-Boc-1,4-cyclohexanediamine Chemical Properties, Uses, Production

Uses

trans-N-Boc-1,4-cyclohexanediamine is used in the preparation of orally bioavailable and selective V1A receptor antagonist.

Uses

trans-4-(Boc-amino)cyclohexylamine is used in the preparation of orally bioavailable and selective V1A receptor antagonist.

Synthesis

24424-99-5

2615-25-0

177906-48-8

Example 17. General procedure for the synthesis of tert-butyl trans-(4-aminocyclohexyl)carbamate (SB1-E-21-1) from di-tert-butyl dicarbonate and trans-1,4-cyclohexanediamine: To a methanol (100 mL) solution of SM-21-1 (2.0 g, 17.5 mmol) was slowly added dropwise a methanol (60 mL) solution of di-tert-butyl dicarbonate (1.1 g, 5.04 mmol). ) solution in methanol (60 mL) for 30 minutes. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. Water (50 mL) was added to the residue and stirring was continued for 20 minutes at room temperature, followed by filtration. The filtrate was extracted with ethyl acetate (120 mL x 2), and the organic phases were combined and washed sequentially with water (50 mL x 2) and saturated saline (50 mL x 2). The organic phase was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent to afford the target product SB1-E-21-1 (off-white solid, 900 mg, 83% yield).

References

[1] Chemistry - An Asian Journal, 2010, vol. 5, # 4, p. 877 - 886
[2] Patent: WO2016/160617, 2016, A2. Location in patent: Paragraph 00401
[3] Journal of Organic Chemistry, 1996, vol. 61, # 25, p. 8811 - 8818
[4] Patent: WO2016/116563, 2016, A1. Location in patent: Page/Page column 34-35
[5] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 352

trans-N-Boc-1,4-cyclohexanediamine synthesis

Synthesis of trans-N-Boc-1,4-cyclohexanediamine from Di-tert-butyl dicarbonate and trans-1,4-Diaminocyclohexane

trans-N-Boc-1,4-cyclohexanediamine Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate trans-1,4-Diaminocyclohexane

Preparation Products

(1R,4R)-(4-MethylaMino-cyclohexyl)-carbaMic acid tert-butyl ester tert-Butyl (1R*,4R*)-4-(benzylamino)cyclohexylcarbamate (1R,4R)- [4-(2-Chloro-acetylaMino)-cyclohexyl]-carbaMic acid tert-butyl ester tert-Butyl (1R*,4R*)-4-acetamidocyclohexylcarbamate

trans-N-Boc-1,4-cyclohexanediamine Suppliers

Global Suppliers ( 232)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Co TC SR Technology Co., Ltd.	027-13487090-306 13487090306	48011371@qq.com	China	98	58
Chengdu Firster Pharmaceutical Co., Ltd.	028-87078428 028-87074958	chengzhenyong@cdfirster.com	China	2580	60
Shanghai Balmxy Pharmaceutical Co., Ltd	021-24206007 13764915196	sales@balmxy.com	China	6959	55
Tangshan Huanhe Technology Co., Ltd	022-13615473007 13615473007	760076777@qq.com	China	80	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
Capot Chemical Co., Ltd	+86 (0) 571 85 58 67 18		China	18187	66
JinYan Chemicals(ShangHai) Co.,Ltd.	13817811078	sales@jingyan-chemical.com	China	9963	60
Accela ChemBio Co.,Ltd.	021-50795510 4000665055	marketing@accelachem.com	China	10972	64
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64

Supplier	Advantage
Wuhan Co TC SR Technology Co., Ltd.	58
Chengdu Firster Pharmaceutical Co., Ltd.	60
Shanghai Balmxy Pharmaceutical Co., Ltd	55
Tangshan Huanhe Technology Co., Ltd	58
J & K SCIENTIFIC LTD.	76
Alfa Aesar	84
Capot Chemical Co., Ltd	66
JinYan Chemicals(ShangHai) Co.,Ltd.	60
Accela ChemBio Co.,Ltd.	64
Nanjing Chemlin Chemical Co., Ltd	64

View Latest Price from trans-N-Boc-1,4-cyclohexanediamine manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-09-15	TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE 177906-48-8	$8.50	1KG	99%	15MT	Wuhan Han Sheng New Material Technology Co.，Ltd
2023-09-15	N-Boc-transcyclohexanediamine 177906-48-8	$8.60	1KG	99%	15MT	Wuhan Han Sheng New Material Technology Co.，Ltd
2023-09-15	tert-butyl (1r,4r)-4-aminocyclohexylcarbamate 177906-48-8	$8.70	1KG	99%	15MT	Wuhan Han Sheng New Material Technology Co.，Ltd

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
177906-48-8
$8.50
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

N-Boc-transcyclohexanediamine
177906-48-8
$8.60
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

tert-butyl (1r,4r)-4-aminocyclohexylcarbamate
177906-48-8
$8.70
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

trans-N-Boc-1,4-cyclohexanediamine Spectrum

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE(177906-48-8)¹HNMR

177906-48-8 (trans-N-Boc-1,4-cyclohexanediamine) Related Search:

Z-Hyp-OMe (4-aminocyclohexyl)methanol trans-4-Aminocyclohexanemethanol Dibutyl fumarate Monomethyl fumarate

Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Fmoc-L-hydroxyproline Trans-(4-aminomethylcyclohexyl)acetic acid HCl trans-3-fluoro-3-methylcyclobutane-1-carboxylic acid tert-Butyl trans-4-formylcyclohexylcarbamate

trans-1,4-Cyclohexanedicarboxylic acid monomethyl ester Dimethyl trans-1,4-cyclohexanedicarboxylate Cyclohexane carbonyl chlorlde 1-N-Boc-1,2-trans-cyclohexyldiamine trans-N-Boc-1,4-cyclohexanediamine

N-Boc-1,4-cyclohexanediamine trans-1,4-Diaminocyclohexane (1S,2S)-trans-N-Boc-1,2-Cyclohexanediamine

1of4

tert-butyl (1r,4r)-4-aminocyclohexylcarbamate tert-Butyl (trans-4-aminocyclohex-1-yl)carbamate, trans-1,4-Diaminocyclohexane, N-BOC protected trans-Cyclohexane-1,4-diamine, N-BOC protected rel-tert-butyl N-[(1R,4R)-4-aMinocyclohexyl]carbaMate trans-4-(Boc-aMino)cyclohexylaMine Trans-1-(N-Boc AMino)-4-AMino cyclohexane tert-butyl ((1r,4r)-4-aMinocyclohexyl)carbaMate hydrochloride Trans-1-N-Boc-1,4-Cyclohexanediamine tert-Butyl trans-N-(4-aminocyclohexyl)carbamate trans-N-Boc-1,4-cyclohexanediamine, >=98% trans-tert-Butyl (4-aminocyclohexyl) carbamate Trans-N-Boc-cyclohexane-1,4-diamine TERT-BUTYL TRANS-4-AMINOCYCLOHEXYLCARBAMATE TRANS-(4-AMINO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER TRANS-1-BOC-AMINO-1,4-CYCLOHEXANEDIAMINE 1-N-BOC-TRANS-1,4-CYCLOHEXYLDIAMINE CarbaMic acid, N-(trans-4-aMinocyclohexyl)-, 1,1-diMethylethyl ester trans-4-(Boc-amino)cyclohexanamine Trans-1N-Boc-cyclohexane-1,4-diamine trans-Cyclohexane-1,4-diamine, N1-BOC protected trans-4-(Boc-amino)cyclohexylamine,97% 1,1-Dimethylethyl N-(trans-4-aminocyclohexyl)carbamate 177906-48-8 tert-Butyl N-(trans-4-aminocyclohexyl)-carbamate N-Boc-transcyclohexanediamine N-BOC-TRANS-1,4-CYCLOHEXANEDIAMINE trans-N-Boc-1,4-cyclohexanediamine 177906-48-8 pharmacetical 177906-48-8