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TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE structure

CAS No.: 177906-48-8

Chemical Name:: TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE

Synonyms: N-BOC-TRANS-1,4-CYCLOHEXANEDIAMINE;trans-4-(Boc-amino)cyclohexanamine;N-Boc-transcyclohexanediamine;trans-4-(Boc-aMino)cyclohexylaMine;TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE;Trans-N-Boc-cyclohexane-1,4-diamine;1-N-BOC-TRANS-1,4-CYCLOHEXYLDIAMINE;Trans-1-N-Boc-1,4-Cyclohexanediamine;Trans-1N-Boc-cyclohexane-1,4-diamine;trans-4-(Boc-amino)cyclohexylamine,97%

CBNumber:: CB1268261

Molecular Formula:: C11H22N2O2

Molecular Weight:: 214.3

MDL Number:: MFCD03001719

MOL File:: 177906-48-8.mol

MSDS File:: SDS

Last updated:2025-07-24 18:13:45

Product description	Number	Pack Size	Price
trans-N-Boc-1,4-cyclohexanediamine	B646235	1g	$120
N-Boc-trans-1,4-cyclohexanediamine	239999	1g	$289
N-Boc-trans-1,4-cyclohexyldiamine	FB34174	50g	$400
tert-Butyltrans-N-(4-aminocyclohexyl)carbamate ≥98.0%	CS-B0868	100g	$420
N-Boc-trans-1,4-Cyclohexyldiamine	J90922	100g	$590
More product size

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TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Properties

Boiling point	322.1±31.0 °C(Predicted)
Density	1.02±0.1 g/cm3(Predicted)
storage temp.	under inert gas (nitrogen or Argon) at 2–8 °C
form	solid
pka	12.44±0.40(Predicted)
color	White
Water Solubility	Slightly soluble in water.
InChI	InChI=1S/C11H22N2O2/c1-11(2,3)15-10(14)13-9-6-4-8(12)5-7-9/h8-9H,4-7,12H2,1-3H3,(H,13,14)/t8-,9-
InChIKey	FEYLUKDSKVSMSZ-KYZUINATSA-N
SMILES	C(OC(C)(C)C)(=O)N[C@@H]1CC[C@@H](N)CC1
CAS DataBase Reference	177906-48-8(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2922498590

NFPA 704

	0
2		0

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE price More Price(35)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	B646235	trans-N-Boc-1,4-cyclohexanediamine	177906-48-8	1g	$120	2021-12-16	Buy
Usbiological	239999	N-Boc-trans-1,4-cyclohexanediamine	177906-48-8	1g	$289	2021-12-16	Buy
Biosynth Carbosynth	FB34174	N-Boc-trans-1,4-cyclohexyldiamine	177906-48-8	50g	$400	2021-12-16	Buy
ChemScene	CS-B0868	tert-Butyltrans-N-(4-aminocyclohexyl)carbamate ≥98.0%	177906-48-8	100g	$420	2021-12-16	Buy
AK Scientific	J90922	N-Boc-trans-1,4-Cyclohexyldiamine	177906-48-8	100g	$590	2021-12-16	Buy

Product number	Packaging	Price	Buy
B646235	1g	$120	Buy
239999	1g	$289	Buy
FB34174	50g	$400	Buy
CS-B0868	100g	$420	Buy
J90922	100g	$590	Buy

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Chemical Properties,Uses,Production

Uses

trans-N-Boc-1,4-cyclohexanediamine is used in the preparation of orally bioavailable and selective V1A receptor antagonist.

Uses

trans-4-(Boc-amino)cyclohexylamine is used in the preparation of orally bioavailable and selective V1A receptor antagonist.

Synthesis

24424-99-5

2615-25-0

177906-48-8

Example 17. General procedure for the synthesis of tert-butyl trans-(4-aminocyclohexyl)carbamate (SB1-E-21-1) from di-tert-butyl dicarbonate and trans-1,4-cyclohexanediamine: To a methanol (100 mL) solution of SM-21-1 (2.0 g, 17.5 mmol) was slowly added dropwise a methanol (60 mL) solution of di-tert-butyl dicarbonate (1.1 g, 5.04 mmol). ) solution in methanol (60 mL) for 30 minutes. The reaction mixture was stirred at room temperature overnight. Upon completion of the reaction, the solvent was removed by concentration under reduced pressure. Water (50 mL) was added to the residue and stirring was continued for 20 minutes at room temperature, followed by filtration. The filtrate was extracted with ethyl acetate (120 mL x 2), and the organic phases were combined and washed sequentially with water (50 mL x 2) and saturated saline (50 mL x 2). The organic phase was dried with anhydrous sodium sulfate, filtered, and concentrated under reduced pressure to remove the solvent to afford the target product SB1-E-21-1 (off-white solid, 900 mg, 83% yield).

References

[1] Chemistry - An Asian Journal, 2010, vol. 5, # 4, p. 877 - 886
[2] Patent: WO2016/160617, 2016, A2. Location in patent: Paragraph 00401
[3] Journal of Organic Chemistry, 1996, vol. 61, # 25, p. 8811 - 8818
[4] Patent: WO2016/116563, 2016, A1. Location in patent: Page/Page column 34-35
[5] Patent: WO2008/57468, 2008, A1. Location in patent: Page/Page column 352

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE synthesis

Synthesis of TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE from Di-tert-butyl dicarbonate and trans-1,4-Diaminocyclohexane

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Preparation Products And Raw materials

Raw materials

Di-tert-butyl dicarbonate trans-1,4-Diaminocyclohexane

Preparation Products

(1R,4R)-(4-MethylaMino-cyclohexyl)-carbaMic acid tert-butyl ester tert-Butyl (1R*,4R*)-4-(benzylamino)cyclohexylcarbamate (1R,4R)- [4-(2-Chloro-acetylaMino)-cyclohexyl]-carbaMic acid tert-butyl ester tert-Butyl (1R*,4R*)-4-acetamidocyclohexylcarbamate

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Suppliers

Global( 231)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Capot Chemical Co.,Ltd.	+86-（0）57185586718; +8613336195806	sales@capot.com	China	29640	60
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13815	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29822	58
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Accela ChemBio Inc.	+1-858-6993322	info@accelachem.com	United States	21193	58
Wuhan Chemwonders Technology Inc.	027-85778276	info@chemwonders.com	CHINA	176	58
Changzhou Ditong Chemical Co.,Ltd	+86-0519-88298848	info@edengenechem.com	China	2176	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58

Supplier	Advantage
Capot Chemical Co.,Ltd.	60
Shanghai Daken Advanced Materials Co.,Ltd	58
Beijing Cooperate Pharmaceutical Co.,Ltd	55
career henan chemical co	58
Jinan Carbotang Biotech Co.,Ltd.	58
Accela ChemBio Inc.	58
Wuhan Chemwonders Technology Inc.	58
Changzhou Ditong Chemical Co.,Ltd	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58

View Lastest Price from TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2023-09-15	TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE 177906-48-8	US $8.50 / KG	1KG	99%	15MT	Wuhan Han Sheng New Material Technology Co.，Ltd
2023-09-15	N-Boc-transcyclohexanediamine 177906-48-8	US $8.60 / KG	1KG	99%	15MT	Wuhan Han Sheng New Material Technology Co.，Ltd
2023-09-15	tert-butyl (1r,4r)-4-aminocyclohexylcarbamate 177906-48-8	US $8.70 / KG	1KG	99%	15MT	Wuhan Han Sheng New Material Technology Co.，Ltd

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE
177906-48-8
US $8.50 / KG
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

N-Boc-transcyclohexanediamine
177906-48-8
US $8.60 / KG
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

tert-butyl (1r,4r)-4-aminocyclohexylcarbamate
177906-48-8
US $8.70 / KG
99%
Wuhan Han Sheng New Material Technology Co.，Ltd

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE Spectrum

TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE(177906-48-8)¹HNMR

177906-48-8(TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE)Related Search:

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Z-HYP-OME TERT-BUTYL TRANS-4-FORMYLCYCLOHEXYLCARBAMATE Methyl 2,2-difluoro-2-(fluorosulfonyl)acetate Monomethyl fumarate Dibutyl fumarate

trans-4-Aminocyclohexanemethanol (4-aminocyclohexyl)methanol CYCLOHEXANE CARBONYL CHLORLDE Trans-N-Boc-1,2-Cyclohexanediamine TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE

N-Boc-1,4-cyclohexanediamine trans-1,4-Diaminocyclohexane (1S,2S)-trans-N-Boc-1,2-Cyclohexanediamine

1of4

N-Boc-transcyclohexanediamine tert-butyl (1r,4r)-4-aminocyclohexylcarbamate tert-Butyl (trans-4-aminocyclohex-1-yl)carbamate, trans-1,4-Diaminocyclohexane, N-BOC protected trans-Cyclohexane-1,4-diamine, N-BOC protected rel-tert-butyl N-[(1R,4R)-4-aMinocyclohexyl]carbaMate trans-4-(Boc-aMino)cyclohexylaMine Trans-1-(N-Boc AMino)-4-AMino cyclohexane tert-butyl ((1r,4r)-4-aMinocyclohexyl)carbaMate hydrochloride Trans-1-N-Boc-1,4-Cyclohexanediamine tert-Butyl trans-N-(4-aminocyclohexyl)carbamate trans-N-Boc-1,4-cyclohexanediamine, >=98% trans-tert-Butyl (4-aminocyclohexyl) carbamate Trans-N-Boc-cyclohexane-1,4-diamine N-BOC-TRANS-1,4-CYCLOHEXANEDIAMINE TERT-BUTYL TRANS-4-AMINOCYCLOHEXYLCARBAMATE TRANS-N-BOC-1,4-CYCLOHEXANEDIAMINE TRANS-(4-AMINO-CYCLOHEXYL)-CARBAMIC ACID TERT-BUTYL ESTER TRANS-1-BOC-AMINO-1,4-CYCLOHEXANEDIAMINE 1-N-BOC-TRANS-1,4-CYCLOHEXYLDIAMINE CarbaMic acid, N-(trans-4-aMinocyclohexyl)-, 1,1-diMethylethyl ester trans-4-(Boc-amino)cyclohexanamine Trans-1N-Boc-cyclohexane-1,4-diamine trans-Cyclohexane-1,4-diamine, N1-BOC protected trans-4-(Boc-amino)cyclohexylamine,97% 1,1-Dimethylethyl N-(trans-4-aminocyclohexyl)carbamate 177906-48-8 tert-Butyl N-(trans-4-aminocyclohexyl)-carbamate 177906-48-8 pharmacetical 177906-48-8