1-Bromomethyl-isoquinoline
- CAS No.
- 74417-44-0
- Chemical Name:
- 1-Bromomethyl-isoquinoline
- Synonyms
- 1-Bromomethyl-isoquinoline;Isoquinoline, 1-(bromomethyl)-
- CBNumber:
- CB5276389
- Molecular Formula:
- C10H8BrN
- Molecular Weight:
- 222.08
- MDL Number:
- MFCD06657041
- MOL File:
- 74417-44-0.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H319 |
| Precautionary statements | P305+P351+P338 |
1-Bromomethyl-isoquinoline price More Price(37)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Activate Scientific | AS90714 | 1-(Bromomethyl)isoquinoline 95% | 74417-44-0 | 1g | $271 | 2026-06-04 | Buy |
| Activate Scientific | AS90714 | 1-(Bromomethyl)isoquinoline 95% | 74417-44-0 | 5g | $1052 | 2026-06-04 | Buy |
| Synthonix | B64961 | 1-(Bromomethyl)isoquinoline >98% | 74417-44-0 | 250mg | $180 | 2026-05-06 | Buy |
| Synthonix | B64961 | 1-(Bromomethyl)isoquinoline >98% | 74417-44-0 | 1g | $360 | 2026-05-06 | Buy |
| Synthonix | B64961 | 1-(Bromomethyl)isoquinoline >98% | 74417-44-0 | 5g | $1800 | 2026-05-06 | Buy |
1-Bromomethyl-isoquinoline Chemical Properties, Uses, Production
Synthesis
1721-93-3
74417-44-0
The general procedure for the synthesis of 1-(bromomethyl)isoquinoline from 1-methylisoquinoline is as follows: 1. 1-methylisoquinoline (0.99 g, 6.91 mmol), N-bromosuccinimide (NBS, 1.35 g, 1.1 eq.), azobisisobutyronitrile (AIBN, 10 mg, catalytic amount), and carbon tetrachloride (CCl4, 1 mL) were added to a reaction flask. 2. The reaction mixture was heated to reflux for 2 hours. 3. Upon completion of the reaction, the suspended solid particles were removed by filtration and the solids were washed with a small amount of CCl4. 4. The filtrate and washings were combined and concentrated under reduced pressure to remove the solvent. 5. The crude product was purified by column chromatography (eluent: 30% ethyl acetate/hexane) to afford 1-(bromomethyl)isoquinoline (270 mg, yield: 18%) as a violet solid. 6. The structure of the product was determined by 1H-1H-quinolysis. 6. The structure of the product was confirmed by 1H-NMR (500 MHz, CDCl3): δ 8.48 (d, 1H), 8.25 (d, 1H), 7.87 (d, 1H), 7.75-7.67 (m, 2H), 7.65 (d, 1H).
References
[1] Patent: WO2008/16239, 2008, A1. Location in patent: Page/Page column 57-58
1-Bromomethyl-isoquinoline Preparation Products And Raw materials
Raw materials
Preparation Products
1-Bromomethyl-isoquinoline Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Shanghai yirong biology science and technology co., ltd | 18049974220 | 3060526242@qq.com | China | 999 | 60 |
| Amber MolTech LLC | 086-010-62176588 | amber@jyamber.com | China | 10150 | 56 |
| Shanghai Jian Chao Chemical Technology Co., Ltd. | 150-2103-5486 18017383231 | 983544897@qq.com | China | 9335 | 55 |
| SynAsst Chemical. | 021-60343070 | China | 12731 | 55 | |
| Shanghai Xingui Biotechnology Co., Ltd. | 15121041756 | xingui2022@126.com | China | 9954 | 58 |
| ShangHai AmK Pharmaceutical Technology Co., Ltd. | 微信 18019252918 18019252918 | sale@amkchem.com | China | 14982 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Aikon International Limited | 025-66113011 19370895928 | qzhang@aikonchem.com | China | 15390 | 58 |
| Shanghai WangFa Chemical Technology Co., Ltd. | 13918479294 | xiebenfa@163.com | China | 4354 | 58 |
