6-ForMylindolo[3,2-b]carbazole
![6-ForMylindolo[3,2-b]carbazole Structure](CAS/GIF/172922-91-7.gif)
- CAS No.
- 172922-91-7
- Chemical Name:
- 6-ForMylindolo[3,2-b]carbazole
- Synonyms
- FICZ;FICZ, 10 mM in DMSO;6-FORMYLINDOLO A CARBAZOLE;6-FORMYLINDOLO [3,2-B] CARBAZOLE;6-Formylindolo[3,2-b]carbazole (FICZ);Indolo[3,2-b]carbazole-6-carbaldehyde;5H,11H-indolo[3,2-b]carbazole-6-carbaldehyde;5,11-dihydroindolo[3,2-b]carbazole-6-carbaldehyde;5,11-Dihydroindolo[3,2-b]carbazole-6-carboxaldehyde;inhibit,Inhibitor,Aryl Hydrocarbon Receptor,AhR,FICZ
- CBNumber:
- CB5312397
- Molecular Formula:
- C19H12N2O
- Molecular Weight:
- 284.31
- MDL Number:
- MFCD09879259
- MOL File:
- 172922-91-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 630.3±35.0 °C(Predicted) |
|---|---|
| Density | 1.463±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | Soluble in DMSO (up to 10 mg/ml). |
| form | powder |
| pka | 15.66±0.30(Predicted) |
| color | yellow to orange |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month. |
| InChI | InChI=1S/C19H12N2O/c22-10-14-18-12-6-2-4-8-16(12)20-17(18)9-13-11-5-1-3-7-15(11)21-19(13)14/h1-10,20-21H |
| InChIKey | ZUDXFBWDXVNRKF-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2)C2=C1C(C=O)=C1C3=C(NC1=C2)C=CC=C3 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302 | |||||||||
| Precautionary statements | P301+P312+P330 | |||||||||
| WGK Germany | 1 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral | |||||||||
| NFPA 704 |
|
6-ForMylindolo[3,2-b]carbazole price More Price(53)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1489 | FICZ ≥95% (HPLC) | 172922-91-7 | 1MG | $148 | 2026-04-30 | Buy |
| Sigma-Aldrich | SML1489 | FICZ ≥95% (HPLC) | 172922-91-7 | 5MG | $599 | 2026-04-30 | Buy |
| Cayman Chemical | 19529 | 6-Formylindolo[3,2-b]carbazole ≥95% | 172922-91-7 | 500μg | $69 | 2026-04-30 | Buy |
| Cayman Chemical | 19529 | 6-Formylindolo[3,2-b]carbazole ≥95% | 172922-91-7 | 1mg | $127 | 2026-04-30 | Buy |
| Cayman Chemical | 19529 | 6-Formylindolo[3,2-b]carbazole ≥95% | 172922-91-7 | 5mg | $493 | 2026-04-30 | Buy |
6-ForMylindolo[3,2-b]carbazole Chemical Properties, Uses, Production
Description
6-Formylindolo(3,2-b)carbazole (FICZ) (172922-91-7) is a very potent (Kd= 0.07 nM) endogenous ligand for the aryl hydrocarbon receptor (AhR).1,2
Uses
6-Formylindolo[3,2-b]carbazole is a tryptophan photoproduct, suppresses pulmonary eosinophilia and Th2-type cytokine production in a mouse model of ovalbumin-induced allergic asthma.
Biochem/physiol Actions
FICZ is a potent high affinity ligand of the aryl hydrocarbon receptor (AhR), which is a ligand-activated transcription factor that activates the expression of aromatic hydrocarbon metabolizing enzyme genes such as the CYP1A1 gene and has also been shown to have multiple additional roles in cell-cycle regulation, development and maturation of many tissues, control of inflammation, and immune response. FICZ is a photoproduct of tryptophan and is believed to be an endogenous AhR ligand. It is extremely potent, with a Kd value of 0.07 nM.
storage
Store at -20°C
References
[1] A RANNUG. Certain photooxidized derivatives of tryptophan bind with very high affinity to the Ah receptor and are likely to be endogenous signal substances.[J]. The Journal of Biological Chemistry, 1987, 262 32: 15422-15427.
[2] EMMA WINCENT. The suggested physiologic aryl hydrocarbon receptor activator and cytochrome P4501 substrate 6-formylindolo[3,2-b]carbazole is present in humans.[J]. The Journal of Biological Chemistry, 2009: 2690-2696. DOI:10.1074/jbc.m808321200
6-ForMylindolo[3,2-b]carbazole Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Wuxi Donghe Pharmaceutical Technology Co., Ltd. | 63313187 15358055255 | 63313187@qq.com | China | 1982 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| CEG Chemical Science&Technology Co., Ltd. | Mobile:13665161512 | China | 1784 | 58 | |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Shanghai Macklin Biochemical Co.,Ltd. | 15221275939 15221275939 | shenlinxing@macklin.cn | China | 15775 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51389 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9909 | 65 |
| Yancheng KangdiSen Pharmaceutical Co., Ltd. | 13812573443;18052965989 | tongbenwan22@163.com | China | 1975 | 55 |
