SHP099
- CAS No.
- 1801747-42-1
- Chemical Name:
- SHP099
- Synonyms
- SHP099;SHP099 ，S6388;SHP-099 (SHP099);SHP-099 (free base);SHP099, 10 mM in DMSO;6-(4-Amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine;6-(4-amino-4-methylpiperidin-1-yl)-3-(2,3-dichlorophenyl)pyrazin-2-amine;2-Pyrazinamine, 6-(4-amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-;6-(4-Azanyl-4-Methyl-Piperidin-1-Yl)-3-[2,3-Bis(Chloranyl)phenyl]pyrazin-2-Amine
- CBNumber:
- CB53128920
- Molecular Formula:
- C16H19Cl2N5
- Molecular Weight:
- 352.26
- MDL Number:
- MFCD29059453
- MOL File:
- 1801747-42-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| SHP099 ≥98% | 20000 | 500μg | $49 |
| SHP099 ≥98% | 20000 | 1mg | $93 |
| SHP099 ≥98% | 20000 | 5mg | $423 |
| SHP099 ≥98% | 20000 | 10mg | $748 |
| SHP099 | BXC74742 | 1mg | $150 |
| More product size | |||
| Boiling point | 530.4±50.0 °C(Predicted) |
|---|---|
| Density | 1.326±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility |
Water:1.0(Max Conc. mg/mL);2.84(Max Conc. mM) DMSO:21.0(Max Conc. mg/mL);34.07(Max Conc. mM) |
| form | A crystalline solid |
| pka | 9.05±0.20(Predicted) |
| color | Light yellow to yellow |
| InChI | InChI=1S/C16H19Cl2N5/c1-16(20)5-7-23(8-6-16)12-9-21-14(15(19)22-12)10-3-2-4-11(17)13(10)18/h2-4,9H,5-8,20H2,1H3,(H2,19,22) |
| InChIKey | YGUFCDOEKKVKJK-UHFFFAOYSA-N |
| SMILES | C1(N)=NC(N2CCC(N)(C)CC2)=CN=C1C1=CC=CC(Cl)=C1Cl |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
SHP099 price More Price(43)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 20000 | SHP099 ≥98% | 1801747-42-1 | 500μg | $49 | 2026-04-30 | Buy |
| Cayman Chemical | 20000 | SHP099 ≥98% | 1801747-42-1 | 1mg | $93 | 2026-04-30 | Buy |
| Cayman Chemical | 20000 | SHP099 ≥98% | 1801747-42-1 | 5mg | $423 | 2026-04-30 | Buy |
| Cayman Chemical | 20000 | SHP099 ≥98% | 1801747-42-1 | 10mg | $748 | 2026-04-30 | Buy |
| Biosynth | BXC74742 | SHP099 | 1801747-42-1 | 1mg | $150 | 2026-06-04 | Buy |
SHP099 Chemical Properties,Uses,Production
Uses
SHP099 is an allosteric SHP2 inhibitor, with IC50s of 0.690, 1.241, 0.416, 1.968, 2.896 μM for SHP2, SHP2D61Y, SHP2E69K, SHP2A72V, SHP2E76K. SHP099 inhibits cancer cell growth, such as MV4-11 and TF-1 cell (IC50: 0.32 and 1.73 μM). SHP099 inhibits RAS-ERK signaling and inhibits tumor growth[1][2].
in vivo
After a single dose of 30 and 100 mg/kg (red and blue lines, respectively), dose-dependent exposure and modulation of the pharmacodynamic marker p-ERK is observed in the xenografts. A daily oral dose of 10 or 30 mg/kg yield 19% and 61% tumor growth inhibition, respectively. Tumor stasis is achieved at 100 mg/kg[1].
References
[1] Chen YN, et al. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Nature. 2016 Jul 7;535(7610):148-52. DOI:10.1038/nature18621
[2] Sun X, et al. Selective inhibition of leukemia-associated SHP2E69K mutant by the allosteric SHP2 inhibitor SHP099. Leukemia. 2018 May;32(5):1246-1249. DOI:10.1038/s41375-018-0020-5
SHP099 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| career henan chemical co | +86-0371-86658258 | factory@coreychem.com | China | 29780 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10378 | 58 |
| Alfa Chemistry | +1-5166625404; | Info@alfa-chemistry.com | United States | 20000 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 38999 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +86-15965530500 | nickzhang@hangyubiotech.com | China | 9930 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501 | product@acmec-e.com | China | 33301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 54746 | 58 | |
| NANJING YINGWEN BIOTECHNOLOGY CO LTD | +86-13382787392 | sales@aeechem.com | China | 10001 | 58 |
View Lastest Price from SHP099 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | SHP099
1801747-42-1
|
$31.00-72.00 | 99.48% | 10g | TargetMol Chemicals Inc. | ||
 |
2022-02-25 | 6-(4-Amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine
1801747-42-1
|
$3.49 | 1KG | 98% | 10KG | Hong Kong Tiansheng New Material Trading Co., Ltd | |
 |
2022-02-25 | SHP099
1801747-42-1
|
$3.49 | 1KG | 98% | 10kg | Hong Kong Tiansheng New Material Trading Co., Ltd |
-
- SHP099
1801747-42-1
- $31.00-72.00
- 99.48%
- TargetMol Chemicals Inc.
-
- 6-(4-Amino-4-methyl-1-piperidinyl)-3-(2,3-dichlorophenyl)-2-pyrazinamine
1801747-42-1
- $3.49
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
-
- SHP099
1801747-42-1
- $3.49
- 98%
- Hong Kong Tiansheng New Material Trading Co., Ltd
