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alpha-lipoic acid-NHS

CAS No.
40846-94-4
Chemical Name:
alpha-lipoic acid-NHS
Synonyms
lipoic acid-NHS;α-Lipoic acid-NHS;DL-α-Lipoic Acid-NHS;alpha-lipoic acid-NHS;N-Hydroxysuccinimidyl Lipoate;Thioctic acid N-hydroxysuccinimide ester;1,2-Dithiolane-3-pentanoic acid succinimidyl ester;1,2-Dithiolane-3-pentanoic acid succinimidyl ester, 95%;2,5-Dioxopyrrolidin-1-yl 5-(1,2-Dithiolan-3-yl)pentanoate;1,2-Dithiolane-3-pentanoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber:
CB53162829
Molecular Formula:
C12H17NO4S2
Molecular Weight:
303.4
MDL Number:
MFCD09028032
MOL File:
40846-94-4.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-07-16 07:06:08

alpha-lipoic acid-NHS Properties

Melting point 95 °C
Boiling point 437.1±28.0 °C(Predicted)
Density 1.36±0.1(20.0000℃)
solubility Soluble in DMSO, DMF, DCM
form powder to crystal
color White to Yellow to Orange

SAFETY

Risk and Safety Statements

HS Code  29349990

alpha-lipoic acid-NHS price More Price(29)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical L0345 DL-α-Lipoic Acid-NHS 40846-94-4 50MG $87 2026-04-30 Buy
TCI Chemical L0345 DL-α-Lipoic Acid-NHS 40846-94-4 250MG $304 2026-04-30 Buy
Biosynth FL177264 DL-a-Lipoic Acid-NHS 40846-94-4 5mg $900 2026-06-04 Buy
Biosynth FL177264 DL-a-Lipoic Acid-NHS 40846-94-4 50mg $900 2026-06-04 Buy
Biosynth FL177264 DL-a-Lipoic Acid-NHS 40846-94-4 25mg $900 2026-06-04 Buy
Product number Packaging Price Buy
L0345 50MG $87 Buy
L0345 250MG $304 Buy
FL177264 5mg $900 Buy
FL177264 50mg $900 Buy
FL177264 25mg $900 Buy

alpha-lipoic acid-NHS Chemical Properties, Uses, Production

Description

alpha-lipoic acid-NHS contains a lipoic acid group and a terminal NHS group. The NHS group can participate in reactions with primary amine groups to form amide bonds.

Uses

α-Lipoic acid-NHS is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

IC 50

Alkyl/ether

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

alpha-lipoic acid-NHS Preparation Products And Raw materials

Global Suppliers ( 51)
Supplier Tel Email Country ProdList Advantage
Shanghai Huici Pharmaceutical Technology Co., LTD 133-31922809 19372841038 lixing@pharmahuici.com China 853 58
TOKYO CHEMICAL INDUSTRY CO., LTD. 03-36680489 Sales-JP@TCIchemicals.com Japan 28364 80
TCI Europe 320-37350700 sales@tcieurope.eu Europe 23654 75
TCI AMERICA 800-4238616 sales@tciamerica.com Americas 23636 75
Bide Pharmatech Ltd. 400-164-7117 18317119277 product02@bidepharm.com China 40000 60
Shanghai Macklin Biochemical Co.,Ltd. 15221275939 15221275939 shenlinxing@macklin.cn China 15775 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66028182 17714375163 yftan@aikonchem.com China 16674 50
Shanghai YuanYe Biotechnology Co., Ltd. 15026964105 2881489226@qq.com China 89667 60
Jinan elephant international trading co., LTD 13006575422@163.com China 6347 58
Rhawn Reagent 400-400-1332688 18019345275 huyue@rhawn.cn China 14942 58

View Latest Price from alpha-lipoic acid-NHS manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
α-Lipoic acid-NHS pictures 2026-07-15 α-Lipoic acid-NHS
40846-94-4
10g TargetMol Chemicals Inc.
lipoic acid-NHS pictures 2025-06-07 lipoic acid-NHS
40846-94-4
5g >95.00% 5g Xian confluore Biological Technology Co., Ltd.
  • lipoic acid-NHS pictures
  • lipoic acid-NHS
    40846-94-4
  • $0.00
  • >95.00%
  • Xian confluore Biological Technology Co., Ltd.
lipoic acid-NHS alpha-lipoic acid-NHS Thioctic acid N-hydroxysuccinimide ester 1,2-Dithiolane-3-pentanoic acid succinimidyl ester, 95% N-Hydroxysuccinimidyl Lipoate 2,5-Dioxopyrrolidin-1-yl 5-(1,2-Dithiolan-3-yl)pentanoate 5-(1,2-Dithiolan-3-yl)pentanic Acid 2,5-Dioxopyrrolidin-1-yl Ester DL-α-Lipoic Acid-NHS α-Lipoic acid-NHS Thioctic acid (2,5-dioxopyrrolidin-1-yl 5-(1,2-dithiolan-3-yl)pentanoate) 1,2-Dithiolane-3-pentanoic acid, 2,5-dioxo-1-pyrrolidinyl ester 2,5-dioxypyrolidine-1-yl5-(1,2-dithiocyclopentane-3-yl)pentanoic acidester 1,2-Dithiolane-3-pentanoic acid succinimidyl ester 40846-94-4