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N,N'-Disuccinimidyl carbonate

N,N'-Disuccinimidyl carbonate structure

CAS No.: 74124-79-1

Chemical Name:: N,N'-Disuccinimidyl carbonate

Synonyms: DSC;Bis(2,5-dioxopyrrolidin-1-yl) carbonate;DISUCCINIMIDYL CARBONATE;SU2O;DI(N-SUCCINIMIDYL) CARBONATE;DI(SUCCINIMIDO) CARBONATE;N'-Disuccinimidyl carbonate;BIS(N-SUCCINIMIDYL) CARBONATE;Carbonic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester;(SUO)2CO

CBNumber:: CB3323388

Molecular Formula:: C9H8N2O7

Molecular Weight:: 256.17

MDL Number:: MFCD00009767

MOL File:: 74124-79-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-05-28 03:31:26

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N,N'-Disuccinimidyl carbonate Properties

Melting point	190 °C (dec.)(lit.)
Boiling point	399.41°C (rough estimate)
Density	1.5670 (rough estimate)
refractive index	1.5600 (estimate)
storage temp.	-20°C
solubility	Dichloromethane (Slightly, Heated), DMSO
form	Crystalline Powder
color	White to slightly yellow
Water Solubility	Soluble in dimethyl sulfoxide, hot pyridine, acetonitrile and most organic solvents. Insoluble in water.
BRN	1499137
Stability	Moisture Sensitive
Major Application	peptide synthesis
InChI	InChI=1S/C9H8N2O7/c12-5-1-2-6(13)10(5)17-9(16)18-11-7(14)3-4-8(11)15/h1-4H2
InChIKey	PFYXSUNOLOJMDX-UHFFFAOYSA-N
SMILES	C(ON1C(=O)CCC1=O)(=O)ON1C(=O)CCC1=O
CAS DataBase Reference	74124-79-1(CAS DataBase Reference)
UNSPSC Code	12352108
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Warning

Hazard statements

H302-H319-H373

Precautionary statements

P260-P264-P270-P301+P312-P305+P351+P338-P314

PPE

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Hazard Codes

Risk Statements

Safety Statements

WGK Germany

TSCA

HS Code

29299000

Storage Class

11 - Combustible Solids

Hazard Classifications

Acute Tox. 4 Oral
Eye Irrit. 2
STOT RE 2 Oral

REACH Registrations

Active

NFPA 704

	0
2		1

N,N'-Disuccinimidyl carbonate price More Price(113)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	8.51005	DSC N,N′-Disuccinimidyl carbonate Novabiochem?	74124-79-1	25g	$242	2026-04-30	Buy
Sigma-Aldrich	8.51005	DSC N,N′-Disuccinimidyl carbonate Novabiochem?	74124-79-1	100g	$722	2026-04-30	Buy
Sigma-Aldrich	8.14971	Di-(N,N′-succinimidyl) carbonate for synthesis	74124-79-1	5G	$189	2026-04-30	Buy
Sigma-Aldrich	225827	N,N′-Disuccinimidyl carbonate ≥95%	74124-79-1	1g	$47.1	2026-04-30	Buy
Sigma-Aldrich	225827	N,N′-Disuccinimidyl carbonate ≥95%	74124-79-1	5g	$122	2026-04-30	Buy

Product number	Packaging	Price	Buy
8.51005	25g	$242	Buy
8.51005	100g	$722	Buy
8.14971	5G	$189	Buy
225827	1g	$47.1	Buy
225827	5g	$122	Buy

N,N'-Disuccinimidyl carbonate Chemical Properties, Uses, Production

Chemical Properties

N,N'-Disuccinimidyl carbonate is white to slightly yellow crystalline powder

Uses

N,N’Disuccinimidyl Carbonate is a commonly used reagent for the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate, synthesis of urea, carbamates and coupling of lig ands to proteins. The coupling reagent property of N,N’Disuucinimidyl Carbonate speeds up coupling process, while reduces the loss of chiral integrity.

Uses

N,N'-Disuccinimidyl carbonate is a convenient reagent for the synthesis of N-succinimidyl esters of N-protected amino acids.

Uses

N,N'-Disuccinimidyl carbonate is used to prepare cleavable linker succinimide vinylsufonylethyl carbonate for thiol modified-DNA. It serves as a reagent for the synthesis of carbamates. Further, it is used as a coupling reagent as well as in the preparation of N-succinimidyl esters of N-protected amino acids, activated carbonate and coupling of ligand to proteins.

Synthesis Reference(s)

Tetrahedron Letters, 20, p. 4745, 1979 DOI: 10.1016/S0040-4039(01)86699-5

General Description

N,N′-Disuccinimidyl carbonate is used for the HPLC determination of amino compounds.

reaction suitability

reaction type: Coupling Reactions

Synthesis

6066-82-6

28920-43-6

74124-79-1

(9H-fluoren-9-yl)methyl 2,5-dioxopyrrolidine-1-carboxylate

102774-86-7

1. 8 kg (1.25 kmol) of N-hydroxybutanediimide is added to the reactor kettle in a single addition, stirred well, and the temperature in the kettle is maintained at -2°C to 0°C. 2. 300 kg (1.62 kmol) of tributylamine and 450 kg of tetrahydrofuran are mixed in a high level tank and then slowly added to the reactor over a period of 10 to 11 hours in an amount of 50 to 57 kg per hour, maintaining the kettle temperature at not more than 5°C. 3. Due to the exothermic nature of the reaction, after the addition of tributylamine, the reaction vessel was warmed up to room temperature and the reaction was continued for 7.5 h. A large number of white solid crystals (N,N'-disuccinimidyl carbonate) were observed to precipitate out of the reaction solution. 4. Filtration of the reaction mixture: the reaction material was homogeneously introduced into a totally closed centrifuge within 1 h and dried under N2 protection. Subsequently the solids in the centrifuge were washed in two batches with 100 kg of tetrahydrofuran solvent at about 0°C and dried to give 120 kg of wet product. 5. The wet product was dried in a vacuum oven at 40 to 45°C for 7 to 8 hours to constant weight to give 95 kg of white crystalline powder with an HPLC purity of 99.1%. The filtrate obtained by centrifugal separation was used in the next step of the reaction. 6. The centrifugal filtrate and washing solvent from step 3 were combined and introduced into a 2000 L distillation unit. The tetrahydrofuran solvent was removed under vacuum at 0 to 5°C, maintaining the kettle temperature at 40 to 42°C. 7. 7. After removal of the tetrahydrofuran, 230 kg of ethylene dichloride was added, stirred at 40°C and held at 50°C for 0.5 hours. The reaction mixture was subsequently washed three times with 160 kg of water. 8. The phases were separated and the dichloromethane phase was added to a 500 L autoclave for subsequent processing.

References

[1] Patent: CN104030962, 2016, B. Location in patent: Paragraph 0036-0041

N,N'-Disuccinimidyl carbonate Preparation Products And Raw materials

Raw materials

N-Hydroxysuccinimide 9-Fluorenylmethyl chloroformate Tetrahydrofuran Tributylamine

Preparation Products

DL-Methamphetamine alpha-lipoic acid-NHS N-Succinimidyl Methacrylate Boc-Leu-OSu 1-(2-(Trimethylsilyl)ethoxycarbonyloxy)&

3,3`-Dithiobispropanoic acid bis(N-hydroxysucciniMde ester) Carbonic acid, 2,5-dioxo-1-pyrrolidinyl 2-(2-methoxyethoxy)ethyl ester m-PEG3-NHS carbonate BCN-Osu BIOTIN-XX-NHS

N,N'-Di-Boc-L-lysine hydroxysuccinimide ester

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N,N'-Disuccinimidyl carbonate Suppliers

Global Suppliers ( 599)

Supplier	Tel	Email	Country	ProdList	Advantage
Suzhou Highfine Biotech Co., Ltd	0512-69209928 18796809688	zhouyingxiang@highfine.com	China	473	75
GenChem & GenPharm (Changzhou) Co., Ltd.	0519-85720003 18861157602	410649415@qq.com	China	111	58
Shandong Mingfeng Pharmaceutical and Technology Co. Ltd	053155551677 15315114555	1345456643@qq.com	China	298	58
Shandong DexinyuanPharmaceutical and Technology Co. Ltd	13583161331	81067618@qq.com	China	113	58
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
future industrial shanghai co., ltd	400-0066400 13621662912	sales@jonln.com	China	1989	65
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TAIYUAN RHF CO.,LTD.	+86 351 7031519	sales@RHFChem.com	China	2334	56

Supplier	Advantage
Suzhou Highfine Biotech Co., Ltd	75
GenChem & GenPharm (Changzhou) Co., Ltd.	58
Shandong Mingfeng Pharmaceutical and Technology Co. Ltd	58
Shandong DexinyuanPharmaceutical and Technology Co. Ltd	58
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
future industrial shanghai co., ltd	65
Alfa Aesar	84
TAIYUAN RHF CO.,LTD.	56

View Latest Price from N,N'-Disuccinimidyl carbonate manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-08-12	N,N'-Disuccinimidyl carbonate 74124-79-1	$115.00	1KG	98%	1-10mt	Baoji Guokang Healthchem Co., Ltd.
2026-03-20	N,N'-Disuccinimidyl carbonate 74124-79-1	$10.00	1KG	99%	5tons	Hebei Chuanghai Biotechnology Co., Ltd
2025-04-04	N,N'-Disuccinimidyl carbonate 74124-79-1		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

N,N'-Disuccinimidyl carbonate
74124-79-1
$115.00
98%
Baoji Guokang Healthchem Co., Ltd.

N,N'-Disuccinimidyl carbonate
74124-79-1
$10.00
99%
Hebei Chuanghai Biotechnology Co., Ltd

N,N'-Disuccinimidyl carbonate
74124-79-1
98%
Henan Aochuang Chemical Co.,Ltd.

N,N'-Disuccinimidyl carbonate Spectrum

N,N'-Disuccinimidyl carbonate(74124-79-1)¹HNMR N,N'-Disuccinimidyl carbonate(74124-79-1)Raman N,N'-Disuccinimidyl carbonate(74124-79-1)FT-IR N,N'-Disuccinimidyl carbonate(74124-79-1)IR

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2,5-PYRROLIDINEDIONE, 1,1'-[CARBONYLBIS(OXY)]BIS- di-N,N'-succnimidly carbonat Carbonic acid bis-(2,5-dioxo-pyrrolidin-1-yl) ester N,Nzzhlxy-Disuccinimidyl carbonate (DSC) Carbonic acid, bis(2,5-dioxo-1-pyrrolidinyl) ester N-Succinimidyl Carbonate N,N'-Disuccinimidyl Carbonate DSC DI-(N,N'-SUCCINIMIDYL) CARBONATE FOR SYN N,N-DisucciniMdyl carbonate Bis(2,5-dioxopyrrolidin-1-yl) carbonate 98% N,N'-Disuccinimidyl carbonate, DSC, 1,1'-[Carbonylbis(oxy)]dipyrrolidine-2,5-dione N,N'-DisucciniMidyl carbonate >=95% N,N'-DisucciniMidyl carbonate puruM, >=95.0% (NMR) N,N′-Disuccinimidyl carbonate N,N'-DISUCCINIMIDYL CARBONATE, TECH. DSC [N,N'-DISUCCINIMIDYL CARBONATE] N,N'-Disuccinimidyl carbonate (DSC) N,N'-DisuccinimidylCarbonate98% N,N'-Disuccinimido Carbonate DSCsee24500 N,N'-Disuccinimidyl N,N'-Disuccinimidyl carbonate, tech. 85%, remainder N-hydroxysuccinimide N-Succinimidyl carbonate, Di(N-succinimidyl) carbonate, DSC N,N'-Disuccinimidyl carbonate ,99% 1,1'-(Carbonylbisoxy)bis(pyrrolidine-2,5-dione) 1,1'-[Carbonylbis(oxy)]bis(2,5-pyrrolidinedione) Carbonic acid bis(succinimidyl) ester N,N'-(Carbonylbisoxy)bissuccinimide DSC (Di(N-succinimidyl)carbonate 1,1''-[CARBONYLBIS(OXY)]DIPYRROLIDINE-2,5-DIONE Disuccinimidyl carbonate, Su2O DSC (Di(N-succinimidyl)carbonate: N-Succinimidyl carbonate) N,N'-Disuccinimidyl carbonate≥ 99% (HPLC) DSC N,N'-Disuccinimidyl carbonate Novabiochem Di-(N,N'-succinimidyl) carbonate for synthesis TIMTEC-BB SBB005976 (SUO)2CO BIS(N-SUCCINIMIDYL) CARBONATE DI-(N,N'-SUCCINIMIDYL) CARBONATE LABOTEST-BB LT00847311 N-SUCCINIMIDYL CARBONATE Di(N-succinimidyl)Carbonate> N,N''-Disuccinimidyl carbonate, Tech Grade N,N'-Disuccinimidyl carbonate USP/EP/BP N,N′-Disuccinimidyl Carbonate (Technical Grade) Di-(N-Succinimidyl) Carbonate extrapure, 95% N. N '- Disuccinimide carbonate N,N' -dissuccinimide carbonate N,N'-Disuccinimidyl carbonate DSCN,N'-Disuccinimidyl carbonate N,N'-Disuccinimidyl Carbonate（DSC） N,N''-Disuccinimidyl carbonate (DSC) N,N′-Disuccinimidyl carbonate N,N'-Disuccinimidyl Carbonate N'-Disuccinimidylcarbonate(DSC) Di-(N-Succinimidyl)Carbon... DSC (Dicyclohexylcarbodiimide) -Disuccinimidyl carbonate Bis(2,5-dioxopyrrolidin-1-yl) carbonate