2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid
- CAS No.
- 1268863-35-9
- Chemical Name:
- 2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid
- Synonyms
- BioE1115;BIOE-1115;BioE-1115 ，S0995;BioE-1115, 10 mM in DMSO;PAS Kinase Inhibitor, BioE-1115;2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid;6-Quinoxalinecarboxylic acid, 2-(4-fluorophenyl)-3-[methyl(1-methylethyl)amino]-;BioE 1115,Threonine proteases,Ser/Thr Protease,Inhibitor,BioE1115,inhibit,Serine proteases,Serine endopeptidases,BioE-1115,Casein Kinase
- CBNumber:
- CB53166382
- Molecular Formula:
- C19H18FN3O2
- Molecular Weight:
- 339.3635232
- MDL Number:
- MFCD31381032
- MOL File:
- 1268863-35-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.32306 | PAS Kinase Inhibitor, BioE-1115 | 1268863-35-9 | 10 mg | $243 | 2026-04-30 | Buy |
| Biosynth | TAC86335 | BioE-1115 | 1268863-35-9 | 50mg | $887.5 | 2026-06-05 | Buy |
| Biosynth | TAC86335 | BioE-1115 | 1268863-35-9 | 0.5g | $2843.8 | 2026-06-05 | Buy |
| ChemScene | CS-0106727 | BioE-1115 98.17% | 1268863-35-9 | 5mg | $65 | 2026-06-04 | Buy |
| ChemScene | CS-0106727 | BioE-1115 98.17% | 1268863-35-9 | 10mg | $97 | 2026-06-04 | Buy |
2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid Chemical Properties, Uses, Production
Uses
BioE-1115 is a highly selective and potent PAS kinase (PASK) inhibitor with an IC50 of ~4 nM. BioE-1115 is also a potent casein kinase 2α inhibitor with an IC50 of ~10 μM[1].
Biological Activity
Cell permeable: yes', 'Primary Target
PASK
in vivo
BioE-1115 (1-100 mg/kg; oral gavage; daily; for 7 days; male Sprague-Dawley rats) treatment shows a dose-dependent suppression of the expression of Gpat1, Fasn and all other SREBP-1c target genes analyzed. SREBP-1 maturation in liver is also suppressed in BioE-1115 treated rats at 10, 30 and 100 mg/kg doses. A calculated measure of insulin resistance, HOMA-IR, is decreased in a dose-dependent manner by BioE-1115 administration. Hepatic and serum TAG are decreased in a dose-dependent manner by BioE-1115 administration. BioE-1115 treatment causes a significant decrease in serum glucose. Both SREBP-1c and SREBP-1a mRNA are modestly decreased at the highest doses. Neither dose of BioE-1115 causes a significant change in either liver weight or body weight[1].
| Animal Model: | Male Sprague-Dawley rats (12 weeks of age; 129.4 ± 0.63 g) fed with high fructose diet[1] |
| Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg, 30 mg/kg and 100 mg/kg |
| Administration: | Oral gavage; daily; for 7 days |
| Result: | Treated with 10, 30 and 100 mg/kg, showed a dose-dependent suppression of the expression of Gpat1, Fasn and all other SREBP-1c target genes analyzed. Decreased hepatic expression of lipogenic SREBP-1c target genes, decreased serum triglycerides and partially reversed insulin resistance. |
IC 50
CK2α: 10 μM (IC50)
References
[1] Wu X, et al. PAS kinase drives lipogenesis through SREBP-1 maturation. Cell Rep. 2014 Jul 10;8(1):242-55. DOI:10.1016/j.celrep.2014.06.006
2-(4-fluorophenyl)-3-(isopropyl(methyl)amino)quinoxaline-6-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| T&W GROUP | 021-61551611 13296011611 | contact@trustwe.com | China | 9884 | 58 |
| Struchem Co., Ltd. | 0512-63009836 18994340901 | helen@struchem.com | China | 3968 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Shanghai Chaolan Chemical Technology Center | QQ：65489617 13301690235 | Sales@ATKchemical.com | China | 9729 | 58 |
| Shanghai SuperLan Chemcial Technique Centre | 0-2022843681 15618226720 | chaolaichem@foxmail.com | China | 9996 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Kaixin Chemical (Hong Kong) Limited | 010-88886666-01 13112345678 | loyson@qq.com | China | 589 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
