AZD9056 (hydrochloride)
- CAS No.
- 345303-91-5
- Chemical Name:
- AZD9056 (hydrochloride)
- Synonyms
- AZD-9056 HCl;AZD 9056 HCl - Bio-X;AZD9056 (hydrochloride);AZD9056 hydrochloride, 10 mM in DMSO;AZD-9056 HYDROCHLORIDE; AZD 9056 HYDROCHLORIDE;N-(goldalkane-1-ylmethyl)-2-chloro-5-(3-((3-hydroxypropyl)amino)propyl)benzamidehydrochloride;AZD9056 hydrochloride,AZD 9056,AZD-9056,P2X Receptor,P2XRs,Inhibitor,AZD-9056 hydrochloride,AZD9056,inhibit
- CBNumber:
- CB53167596
- Molecular Formula:
- C24H36Cl2N2O2
- Molecular Weight:
- 455.46
- MDL Number:
- MFCD30718168
- MOL File:
- 345303-91-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| storage temp. | Store at -20°C |
|---|---|
| solubility | DMSO : ≥ 34 mg/mL (74.65 mM) |
| form | Solid |
| color | White to off-white |
| FDA UNII | 0CZ6S167ZM |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H317-H373-H361-H302 |
| Precautionary statements | P261-P272-P280-P302+P352-P333+P313-P321-P363-P501-P201-P202-P281-P308+P313-P405-P501-P260-P314-P501-P264-P270-P301+P312-P330-P501 |
AZD9056 (hydrochloride) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-6172 | AZD9056 hydrochloride 98.18% | 345303-91-5 | 5mg | $125 | 2026-06-04 | Buy |
| ChemScene | CS-6172 | AZD9056 hydrochloride 98.18% | 345303-91-5 | 10mg | $209 | 2026-06-04 | Buy |
| ChemScene | CS-6172 | AZD9056 hydrochloride 98.18% | 345303-91-5 | 25mg | $466 | 2026-06-04 | Buy |
| aablocks | AA01E7NI | N-(Adamantan-1-ylmethyl)-2-chloro-5-(3-((3-hydroxypropyl)amino)propyl)benzamide hydrochloride | 345303-91-5 | 2mg | $48 | 2026-05-30 | Buy |
| aablocks | AA01E7NI | N-(Adamantan-1-ylmethyl)-2-chloro-5-(3-((3-hydroxypropyl)amino)propyl)benzamide hydrochloride | 345303-91-5 | 5mg | $65 | 2026-05-30 | Buy |
AZD9056 (hydrochloride) Chemical Properties, Uses, Production
Uses
AZD9056 hydrochloride is a selective orally active inhibitor of P2X7 which plays a significant role in inflammation and pain-causing diseases.
in vivo
Treatment with AZD9056 exerts pain-relieving and anti-inflammatory effects. The upregulated expression of interleukin (IL)-1β, IL-6, tumor necrosis factor-α (TNF-α), matrix metalloproteinase-13 (MMP-13), substance P (SP) and prostaglandin E2 (PGE2) which is induced by MIA in cartilage tissues is reversed by AZD9056[3].
IC 50
P2X7 Receptor
References
[1] Seeland S, et al. ATP-induced cellular stress and mitochondrial toxicity in cells expressing purinergic P2X7 receptor. Pharmacol Res Perspect. 2015 Mar;3(2):e00123. DOI:10.1002/prp2.123
[2] Elsby R, et al. In vitro risk assessment of AZD9056 perpetrating a transporter-mediated drug-drug interaction with methotrexate. Eur J Pharm Sci. 2011 May 18;43(1-2):41-9. DOI:10.1016/j.ejps.2011.03.006
[3] Hu H, et al. Blocking of the P2X7 receptor inhibits the activation of the MMP-13 and NF-κB pathways in the cartilage tissue of rats with osteoarthritis. Int J Mol Med. 2016 Dec;38(6):1922-1932. DOI:10.3892/ijmm.2016.2770
AZD9056 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4853 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6378 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6745 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
View Latest Price from AZD9056 (hydrochloride) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-15 | AZD9056 hydrochloride
345303-91-5
|
$56.00-211.00 | 99.68% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-15 | AZD9056 hydrochloride
345303-91-5
|
$56.00-211.00 | 99.68% | 10g | TargetMol Chemicals Inc. |
-
- AZD9056 hydrochloride
345303-91-5
- $56.00-211.00
- 99.68%
- TargetMol Chemicals Inc.
-
- AZD9056 hydrochloride
345303-91-5
- $56.00-211.00
- 99.68%
- TargetMol Chemicals Inc.
