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2-Chloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine Structure
2-Chloro-5-fluoropyrimidine structure
CAS No.
62802-42-0
Chemical Name:
2-Chloro-5-fluoropyrimidine
Synonyms
2-Chloro-5-fluoropyr;Fampridine Impurity 213;2-CHLORO-5-FLUOROPYRIMIDINE;2-Chloro-5-fluoropyriMidi...;Pyrimidine,2-chloro-5-fluoro-;2-Chloro-5-fluoro-1,3-diazine;2-Chloro-5-fluoropyrimidine >2-Chloro-5-fluoropyrimidine ,98%;Pyrimidine, 2-chloro-5-fluoro- (9CI);2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH
CBNumber:
CB5343151
Molecular Formula:
C4H2ClFN2
Molecular Weight:
132.52
MDL Number:
MFCD03788197
MOL File:
62802-42-0.mol
MSDS File:
SDS
Last updated:2026-05-28 05:27:26
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2-Chloro-5-fluoropyrimidine Properties

Boiling point 149.0-162.0°C
Density 1.439 g/mL at 20 °C (lit.)
refractive index n20/D 1.503(lit.)
Flash point 150 °F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
form Liquid
pka -2.54±0.22(Predicted)
color Clear colorless to yellow
InChI InChI=1S/C4H2ClFN2/c5-4-7-1-3(6)2-8-4/h1-2H
InChIKey AGYUQBNABXVWMS-UHFFFAOYSA-N
SMILES C1(Cl)=NC=C(F)C=N1
CAS DataBase Reference 62802-42-0(CAS DataBase Reference)
FDA UNII KK43K2RZ9W
UNSPSC Code 12352100
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Corrosion (GHS05)Exclamation Mark (GHS07)
GHS05,GHS07
Signal word  Danger
Hazard statements  H302-H314
Precautionary statements  P270-P280-P301+P312-P303+P361+P353-P304+P340+P310-P305+P351+P338
PPE Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter
Hazard Codes  Xn,Xi
Risk Statements  22-34-41-37/38
Safety Statements  26-36/37/39-45
RIDADR  UN 2735 8/PG 2
WGK Germany  3
Hazard Note  Harmful
HazardClass  8
HazardClass  IRRITANT
PackingGroup  Ⅲ
HS Code  29335990
Storage Class 8A - Combustible corrosive hazardous materials
Hazard Classifications Acute Tox. 4 Oral
Skin Corr. 1B
Limited Quantities 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid)
Excepted Quantities Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L)
NFPA 704
2
3 0

2-Chloro-5-fluoropyrimidine price More Price(68)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 651753 2-Chloro-5-fluoropyrimidine 97% 62802-42-0 1g $183 2023-06-20 Buy
Sigma-Aldrich 651753 2-Chloro-5-fluoropyrimidine 97% 62802-42-0 250mg $86.8 2023-01-07 Buy
TCI Chemical C2546 2-Chloro-5-fluoropyrimidine >98.0%(GC) 62802-42-0 1g $31 2026-04-30 Buy
TCI Chemical C2546 2-Chloro-5-fluoropyrimidine >98.0%(GC) 62802-42-0 5g $99 2026-04-30 Buy
Usbiological 267521 2-Chloro-5-fluoropyrimidine Asreported 62802-42-0 25g $496 2026-06-03 Buy
Product number Packaging Price Buy
651753 1g $183 Buy
651753 250mg $86.8 Buy
C2546 1g $31 Buy
C2546 5g $99 Buy
267521 25g $496 Buy

2-Chloro-5-fluoropyrimidine Chemical Properties, Uses, Production

Chemical Properties

Colorless to light yellow liquid

Uses

2-Chloro-5-fluoropyrimidine is used to prepare 2,4-disubstituted-5-fluoropyrimidine , which is a biologically active molecule seen in anticancer agents like 5-fluorouracil.

Uses

2-Chloro-5-fluoropyrimidine can be used as a starting material for the preparation of:
5-fluoro-2-amino pyrimidines by reacting with various amines in the presence of K2CO3, via C-N bond forming reaction.
2-chloro-5-(5-fluoropyrimidin-2-yl)benzoic acid, an intermediate, which is used in the synthesis of benzamide scaffolds as potent antagonists against P2X7 receptors.
5-fluoro-2-cyano pyrimidine, a key intermediate used for the synthesis of 5-chloro-N-[(1S)-1-(5-fluoropyrimidin-2-yl)ethyl]-N-(5-methyl-1H-pyrazol-3-yl)pyrimidine-2,4-diamine, as a potent inhibitor of the JAK2 kinase.

Preparation

Synthesis of 2-chloro-5-fluoropyrimidine: add 2,4-Dichloro-5-fluoropyrimidine and reducing metal powder to the solvent, stir to raise the temperature to the reaction temperature, slowly add acid dropwise, and keep the temperature until the reaction is completed Finish. Filtration, phase separation or direct evaporation of the solvent, and distillation under reduced pressure to remove the solvent to obtain 2-chloro-5-fluoropyrimidine.

Synthesis

2,4-Dichloro-5-fluoropyrimidine

2927-71-1

2-Chloro-5-fluoropyrimidine

62802-42-0

Step A: Synthesis of 2-chloro-5-fluoropyrimidine To 2,4-dichloro-5-fluoropyrimidine (15.0 g, 89.8 mmol) was added tetrahydrofuran (100 mL) and zinc powder (17.6 g, 269 mmol). The reaction mixture was heated to 70 °C with vigorous stirring, followed by the slow dropwise addition of acetic acid (5.14 mL, 89.8 mmol) over a period of 1 hour. After completion of the dropwise addition, the reaction mixture was heated to reflux for 5 hours. Upon completion of the reaction, the reaction mixture was diluted with dichloromethane and filtered through a diatomaceous earth pad to remove solid impurities. The filtrate was concentrated under reduced pressure and purified by silica gel column chromatography to afford the target product 2-chloro-5-fluoropyrimidine (6.00 g, 50% yield).

References

[1] A. Dunaiskis. “LARGE SCALE SYNTHESIS OF 2-CHLORO-5-FLUOROPYRIMIDINE.” Organic Preparations and Procedures International 27 1 (1995): 600–602.
[2] A. DUNAISKIS. “ChemInform Abstract: Large Scale Synthesis of 2-Chloro-5-fluoropyrimidine.” ChemInform 26 52 (1995).

2-Chloro-5-fluoropyrimidine synthesis

2927-71-1
62802-42-0
Synthesis of 2-Chloro-5-fluoropyrimidine from 2,4-Dichloro-5-fluoropyrimidine

2-Chloro-5-fluoropyrimidine Preparation Products And Raw materials

Raw materials

2,4-Dichloro-5-fluoropyrimidine Acetic acid Tetrahydrofuran ZINC

Preparation Products

2-Chloro-5-fluoropyrimidine Suppliers

Global Suppliers ( 384)
Supplier Tel Email Country ProdList Advantage
Weifang Yuda Pharmaceutical Technology Co., Ltd. 17663603912 2710256076@qq.com China 196 56
Taizhou FRIEND Chemical Co., Ltd. 025-0523-86200082 15380713688 Austin@fredchem.cn China 153 55
Jiangsu Mingchem Corporation 0519-85170101 sales@mingchem.com China 632 55
Jiangsu Zhongyuan Chemicals Co.,Ltd. 0513-0513-84539538 13817775327 nthp0513@163.com China 33 58
Win-Win Chemical CO., Limited 0577-64498589 15325081899 sales@win-winchemical.com China 1086 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 4006356688 18621169109 market03@meryer.com China 40202 62
Liaoning Tianhua Chemical Co., Ltd. 0418-6530555 2855550 China 338 69
3B Pharmachem (Wuhan) International Co.,Ltd. 18930552037 3bsc@sina.com China 15813 69
Alfa Aesar 400-6106006 saleschina@alfa-asia.com China 30103 84
Supplier Advantage
Weifang Yuda Pharmaceutical Technology Co., Ltd. 56
Taizhou FRIEND Chemical Co., Ltd. 55
Jiangsu Mingchem Corporation 55
Jiangsu Zhongyuan Chemicals Co.,Ltd. 58
Win-Win Chemical CO., Limited 58
J & K SCIENTIFIC LTD. 76
Meryer (Shanghai) Chemical Technology Co., Ltd. 62
Liaoning Tianhua Chemical Co., Ltd. 69
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Alfa Aesar 84

View Latest Price from 2-Chloro-5-fluoropyrimidine manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Chloro-5-fluoropyrimidine pictures 2026-09-15 2-Chloro-5-fluoropyrimidine
62802-42-0
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
2-Chloro-5-fluoropyrimidine pictures 2026-09-02 2-Chloro-5-fluoropyrimidine
62802-42-0
 $1.20-35.00 1kg 99% Henan Fengda Chemical Co., Ltd
2-Chloro-5-fluoropyrimidine pictures 2026-06-30 2-Chloro-5-fluoropyrimidine
62802-42-0
 1KG 98.0% 10000KGS Shaanxi Dideu New Materials Co. Ltd

2-Chloro-5-fluoropyrimidine Spectrum

2-Chloro-5-fluoropyrimidine(62802-42-0)1HNMR2-Chloro-5-fluoropyrimidine(62802-42-0)FT-IR

62802-42-0 (2-Chloro-5-fluoropyrimidine) Related Search:

2-Chloropyrimidine Fluorocytosine 5-Fluoropyrimidine λ-Cyhalothrin 3-(6-chloro-5-fluoropyrimidin-4-yl)-2-(2,4-difluorophenyl)-1-(1H-1,2,4-triazol-1-yl)butan-2-ol
Difluorochloromethane 4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE,4-AMINO-2-CHLORO-5-FLUOROPYRIMIDINE GC 95.0%,2-Chloro-5-fluoropyrimidine-4-amine 2,4-Dichloro-5-fluoropyrimidine 2-Fluoro-3,5-dichloropyridine (2R,3S/2S,3R)-3-(4-Chloro-5-fluoro-6-pyrimidinyl)-2-(2,4-difluorophenyl)butan-2-ol hydrochloride
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2,4-Dichloro-6-ethyl-5-fluoropyrimidine 2-Chloro-5-fluoropyrimidin-4-one CHEMBRDG-BB 4015094

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Pyrimidine, 2-chloro-5-fluoro- (9CI) 2-CHLORO-5-FLUOROPYRIMIDINE Pyrimidine,2-chloro-5-fluoro- 2-Chloro-5-fluoropyr 2-Chloro-5-fluoropyriMidi... 2-Chloro-5-fluoropyrimidine ,98% 2-Chloro-5-fluoro-1,3-diazine 2-Chloro-5-fluoropyrimidine > 2-Chloro-5-fluoropyrimidine ISO 9001：2015 REACH Fampridine Impurity 213 62802-42-0 63802-42-0 802-42-0 C4H2ClFN2 Building Blocks Heterocyclic Building Blocks Halogenated Heterocycles Pyrimidines Fluorine series Bases & Related Reagents Nucleotides Building Blocks Halogenated Heterocycles Heterocyclic Building Blocks PyrimidinesHeterocyclic Building Blocks Variety of halogenated heterocyclic series PYRIMIDINE Pyrimidine series pharmacetical Pyrimidines 62802-42-0