4,6-Dichloro-5-fluoropyrimidine
- CAS No.
- 213265-83-9
- Chemical Name:
- 4,6-Dichloro-5-fluoropyrimidine
- Synonyms
- 4,6-DICHLORO-5-FLUORO-PYRIMIDINE;4,6-Dichloro-5-fluoropyriMidinene;6-Dichloro-5-fluoropyriMidine;4,6-Dichloro-5-Fluoro Pyridine;4,6-Dichloro-5-fluoro-1,3-diazine;Pyrimidine, 4,6-dichloro-5-fluoro-;4,6-Dichloro-5-fluoropyrimidine,98%;4,6-Dichloro-5-fluoropyrimidine ISO 9001：2015 REACH
- CBNumber:
- CB8475240
- Molecular Formula:
- C4HCl2FN2
- Molecular Weight:
- 166.97
- MDL Number:
- MFCD08056331
- MOL File:
- 213265-83-9.mol
- MSDS File:
- SDS
| Boiling point | 50-60℃/14mm |
|---|---|
| Density | 1.605±0.06 g/cm3(Predicted) |
| Flash point | 91°(196°F) |
| storage temp. | under inert gas (nitrogen or Argon) at 2-8°C |
| solubility | DMSO, Methanol (Slightly) |
| form | Liquid |
| pka | -5.42±0.26(Predicted) |
| color | Colourless |
| Water Solubility | Slightly soluble in water. |
| InChI | InChI=1S/C4HCl2FN2/c5-3-2(7)4(6)9-1-8-3/h1H |
| InChIKey | DGMIGAHDDPJOPN-UHFFFAOYSA-N |
| SMILES | C1=NC(Cl)=C(F)C(Cl)=N1 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS05 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H227-H314-H318 | |||||||||
| Precautionary statements | P210e-P260h-P303+P361+P353-P305+P351+P338-P405-P501a | |||||||||
| Safety Statements | 24/25 | |||||||||
| RIDADR | UN3265 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HazardClass | 8 | |||||||||
| HS Code | 29335990 | |||||||||
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
4,6-Dichloro-5-fluoropyrimidine price More Price(71)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 271028 | 4,6-Dichloro-5-fluoropyrimidine Asreported | 213265-83-9 | 25g | $805 | 2026-06-03 | Buy |
| Usbiological | 271028 | 4,6-Dichloro-5-fluoropyrimidine Asreported | 213265-83-9 | 50g | $1210 | 2026-06-03 | Buy |
| Usbiological | 271028 | 4,6-Dichloro-5-fluoropyrimidine Asreported | 213265-83-9 | 100g | $1876 | 2026-06-03 | Buy |
| Usbiological | 271028 | 4,6-Dichloro-5-fluoropyrimidine Asreported | 213265-83-9 | 250g | $3433 | 2026-06-03 | Buy |
| Usbiological | 271028 | 4,6-Dichloro-5-fluoropyrimidine Asreported | 213265-83-9 | 500g | $5734 | 2026-06-03 | Buy |
4,6-Dichloro-5-fluoropyrimidine Chemical Properties, Uses, Production
Uses
4,6-Dichloro-5-Fluoropyrimidine is an useful intermediate for pharmaceuticals.
Synthesis
106615-61-6
213265-83-9
General procedure for the synthesis of 4,6-dichloro-5-fluoropyrimidine from 5-fluoro-4,6-dihydroxypyrimidine (Method B): phosphoryl chloride (0.593 L, 6.376 mol) was slowly added to a 2 L three-necked round-bottomed flask containing 5-fluoropyrimidine-4,6-diol (276.459 g, 2.125 mol) to form a slurry at room temperature. N,N-dimethylaniline (81 mL, 0.638 mol) was slowly added to this slurry through the addition funnel and the reaction was exothermic. The reaction mixture was continued to be stirred at 110°C for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature and slowly poured into a 2 L mixture consisting of brine and ice under stirring. The aqueous layer (showing red color) was extracted with dichloromethane (2 x 2 L). The organic layers were combined and washed sequentially with cold 6 N hydrochloric acid (2 × 1 L, showing honey brown color) and saturated sodium bicarbonate solution (1 L). The organic layer was dried with anhydrous sodium sulfate, filtered through glass fiber paper under vacuum, and concentrated under reduced pressure (without heating) to afford 4,6-dichloro-5-fluoropyrimidine (CAS No. 213265-83-9, 347.9 g, 2.084 mol, 98% yield) as an amber colored oil. Nuclear magnetic resonance (NMR) analysis showed traces of dichloromethane in the product. 4,6-Dichloro-5-fluoropyrimidine (420 g, 2.515 mol) was subjected to vacuum distillation, and the fraction with a boiling point of 35°C (pressure 1 torr) was collected to give a colorless oily substance (332.574 g, 1.992 mol, 79% yield). The product solidified at -78°C and remelted to liquid at room temperature. Distillation conditions: oil bath temperature 100°C; product boiling point 35°C; pressure 1 Torr. 1H NMR (400 MHz, DMSO-d6) δ 8.8 (s, 1H).
References
[1] Patent: WO2012/40279, 2012, A1. Location in patent: Page/Page column 86
[2] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 11
[3] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 12
[4] Patent: WO2003/106432, 2003, A1. Location in patent: Page column 10
4,6-Dichloro-5-fluoropyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Arbor Chemical Co., Ltd. | 021-60451683 15021268886 | sales@arborchemical.com | China | 765 | 55 |
| Jinan Gaochun Pharmaceutical Technology Co., Ltd. | 13287077755 13044030397 | 171790338@qq.com | China | 12 | 58 |
| Jiangsu Zhongyuan Chemicals Co.,Ltd. | 0513-0513-84539538 13817775327 | nthp0513@163.com | China | 33 | 58 |
| Shaoxing Jiatuo Pharmaceutical Technology Co., Ltd. | 0575-13967584673 13967584673 | jianqiu21@sina.com | China | 23 | 58 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| PharmaBlock Sciences (Nanjing),Inc. | 025-86918202 4000255188 | sales@pharmablock.com | China | 5000 | 55 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Capot Chemical Co., Ltd | +86 (0) 571 85 58 67 18 | China | 18187 | 66 | |
| Beijing Ouhe Technology Co., Ltd | 13552068683 13522913783 | 2355560935@qq.com | China | 11777 | 60 |
| Pure Chemistry Scientific Inc. | 001-857-928-2050 or 1-888-588-9418 | sales@chemreagents.com | United States | 10174 | 62 |
View Latest Price from 4,6-Dichloro-5-fluoropyrimidine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-02 | 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
|
$8.00 | 1KG | 99% | Henan Fengda Chemical Co., Ltd | ||
 |
2025-06-25 | 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
|
$1.10 | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2025-04-04 | 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
|
1kg | 98% | 1Ton | Henan Aochuang Chemical Co.,Ltd. |
-
- 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
- $8.00
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
- $1.10
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- 4,6-Dichloro-5-fluoropyrimidine
213265-83-9
- 98%
- Henan Aochuang Chemical Co.,Ltd.
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