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2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester

2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester structure

CAS No.: 769944-39-0

Chemical Name:: 2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester

Synonyms: 1-Boc-2-(4-chlorophenyl)piperazine;t-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate;tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate;2-(4-chlorophenyl)-1-piperazinecarboxylic acid tert-butyl ester;2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-, 1,1-dimethylethyl ester

CBNumber:: CB5354520

Molecular Formula:: C15H21ClN2O2

Molecular Weight:: 296.79

MDL Number:: MFCD08275679

MOL File:: 769944-39-0.mol

Last updated:2026-09-12 18:53:30

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2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester Properties

storage temp.	2-8°C
InChI	InChI=1S/C15H21ClN2O2/c1-15(2,3)20-14(19)18-9-8-17-10-13(18)11-4-6-12(16)7-5-11/h4-7,13,17H,8-10H2,1-3H3
InChIKey	BYPYEMNCKKTEFT-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCNCC1C1=CC=C(Cl)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester price More Price(36)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Matrix Scientific	071933	1-Boc-2-(4-Chlorophenyl)piperazine	769944-39-0	250.00mg	$52	2026-05-18	Buy
Matrix Scientific	071933	1-Boc-2-(4-Chlorophenyl)piperazine	769944-39-0	1.00g	$138	2026-05-18	Buy
Matrix Scientific	071933	1-Boc-2-(4-Chlorophenyl)piperazine	769944-39-0	5.00g	$499	2026-05-18	Buy
Synthonix	B58390	tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate 95+%	769944-39-0	100mg	$100	2026-05-06	Buy
Synthonix	B58390	tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate 95+%	769944-39-0	250mg	$140	2026-05-06	Buy

Product number	Packaging	Price	Buy
071933	250.00mg	$52	Buy
071933	1.00g	$138	Buy
071933	5.00g	$499	Buy
B58390	100mg	$100	Buy
B58390	250mg	$140	Buy

2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester Chemical Properties, Uses, Production

Synthesis

1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-3-oxo-, 1,1-dimethylethyl ester

769944-38-9

2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

769944-39-0

General procedure for the synthesis of tert-butyl 2-(4-chlorophenyl)piperazine-1-carboxylate from the compound (CAS: 769944-38-9): a solution of 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)piperazin-2-one (500 mg, 1.6 mmol) and acetic acid (929 μL, 16 mmol) was added to refluxing 1,4-dioxane (5 mL ), followed by sodium borohydride (608 mg, 16 mmol). The reflux reaction was continued. Upon completion of the reaction, the reaction was quenched with water, the organic phase was extracted with dichloromethane and washed with brine and the organic phase was dried. After removing the solvent under reduced pressure, the residue was purified by silica gel column chromatography to afford 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)piperazine (330 mg, 69% yield).1H-NMR (CDCl3) δ 1.46 (9H, s), 2.76-2.99 (3H, m), 3.13 (1H, dd, J = 13.0 Hz, 4.3 Hz), 3.45-3.49 (3H, m). 3.45-3.49 (2H, m), 3.92 (1H, m), 5.15 (1H, s), 7.27-7.33 (4H, m).

References

[1] Patent: WO2004/85408, 2004, A1. Location in patent: Page 264
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 16, p. 3726 - 3732

2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester Preparation Products And Raw materials

Raw materials

1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-3-oxo-, 1,1-dimethylethyl ester 1,4-Dioxane Acetic acid Sodium borohydride

Preparation Products

2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester Suppliers

Global Suppliers ( 39)

Supplier	Tel	Email	Country	ProdList	Advantage
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10174	62
Shanghai Hong-chuang Pharma Tech Co., Ltd.	18151128828	hc-sales@foxmail.com	China	2635	55
Aloespharm Co., Ltd.	021-20960837	market@aloespharm.com	China	1299	55
Shanghai HuanChuan Industry Co.,Ltd.	021-61478794	sales@hcshhai.com	China	9781	50
Shanghai Boyners Pharm-Tech Co., Ltd.	13817873692	mkt@boynerspharm.com	China	1707	55
Changzhou Hopschain Chemical Co.,Ltd.	85528066 13775048983	sales@hopschem.com	China	31548	55
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131885	58
Aikon International Limited	025-66061636 19370895928	qqyang@aikonchem.com	China	15810	58
SHANGHAI FDC-CHEMICAL CO.,LTD	021-61469567 13774476675	sales@fdc-chemical.com	China	9999	58
Shandong utilizing biological technology co., LTD	18669728830 15966937598	3407650895@qq.com	China	5167	58

Supplier	Advantage
Pure Chemistry Scientific Inc.	62
Shanghai Hong-chuang Pharma Tech Co., Ltd.	55
Aloespharm Co., Ltd.	55
Shanghai HuanChuan Industry Co.,Ltd.	50
Shanghai Boyners Pharm-Tech Co., Ltd.	55
Changzhou Hopschain Chemical Co.,Ltd.	55
Amadis Chemical Company Limited	58
Aikon International Limited	58
SHANGHAI FDC-CHEMICAL CO.,LTD	58
Shandong utilizing biological technology co., LTD	58

769944-39-0 (2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester) Related Search:

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1-Boc-2-(4-chlorophenyl)piperazine tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate t-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate 2-(4-chlorophenyl)-1-piperazinecarboxylic acid tert-butyl ester 1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-, 1,1-dimethylethyl ester 2-(4-Chlorophenyl)piperazine-1-carboxylic acid tert-butyl ester 769944-39-0