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2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER structure

CAS No.: 769944-39-0

Chemical Name:: 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

Synonyms: 1-Boc-2-(4-chlorophenyl)piperazine;t-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate;tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate;2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;2-(4-chlorophenyl)-1-piperazinecarboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-, 1,1-dimethylethyl ester

CBNumber:: CB5354520

Molecular Formula:: C15H21ClN2O2

Molecular Weight:: 296.79

MDL Number:: MFCD08275679

MOL File:: 769944-39-0.mol

Last updated:2025-07-24 18:13:52

Product description	Number	Pack Size	Price
2-(4-Chlorophenyl)piperazine-1-carboxylicAcidtert-ButylEster	C350670	10mg	$50
2-(4-Chlorophenyl)piperazine-1-carboxylicAcidtert-ButylEster	C350670	25mg	$100
1-Boc-2-(4-Chlorophenyl)piperazine	W8368	100mg	$135
1-Boc-2-(4-Chlorophenyl)piperazine	W8368	250mg	$186
2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%	COR0001507	250MG	$302.4

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2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Properties

storage temp.	2-8°C
InChI	InChI=1S/C15H21ClN2O2/c1-15(2,3)20-14(19)18-9-8-17-10-13(18)11-4-6-12(16)7-5-11/h4-7,13,17H,8-10H2,1-3H3
InChIKey	BYPYEMNCKKTEFT-UHFFFAOYSA-N
SMILES	N1(C(OC(C)(C)C)=O)CCNCC1C1=CC=C(Cl)C=C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER price More Price(18)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
TRC	C350670	2-(4-Chlorophenyl)piperazine-1-carboxylicAcidtert-ButylEster	769944-39-0	10mg	$50	2021-12-16	Buy
TRC	C350670	2-(4-Chlorophenyl)piperazine-1-carboxylicAcidtert-ButylEster	769944-39-0	25mg	$100	2021-12-16	Buy
AK Scientific	W8368	1-Boc-2-(4-Chlorophenyl)piperazine	769944-39-0	100mg	$135	2021-12-16	Buy
AK Scientific	W8368	1-Boc-2-(4-Chlorophenyl)piperazine	769944-39-0	250mg	$186	2021-12-16	Buy
American Custom Chemicals Corporation	COR0001507	2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 95.00%	769944-39-0	250MG	$302.4	2021-12-16	Buy

Product number	Packaging	Price	Buy
C350670	10mg	$50	Buy
C350670	25mg	$100	Buy
W8368	100mg	$135	Buy
W8368	250mg	$186	Buy
COR0001507	250MG	$302.4	Buy

2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Chemical Properties,Uses,Production

Synthesis

1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-3-oxo-, 1,1-dimethylethyl ester

769944-38-9

2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER

769944-39-0

General procedure for the synthesis of tert-butyl 2-(4-chlorophenyl)piperazine-1-carboxylate from the compound (CAS: 769944-38-9): a solution of 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)piperazin-2-one (500 mg, 1.6 mmol) and acetic acid (929 μL, 16 mmol) was added to refluxing 1,4-dioxane (5 mL ), followed by sodium borohydride (608 mg, 16 mmol). The reflux reaction was continued. Upon completion of the reaction, the reaction was quenched with water, the organic phase was extracted with dichloromethane and washed with brine and the organic phase was dried. After removing the solvent under reduced pressure, the residue was purified by silica gel column chromatography to afford 4-(tert-butoxycarbonyl)-3-(4-chlorophenyl)piperazine (330 mg, 69% yield).1H-NMR (CDCl3) δ 1.46 (9H, s), 2.76-2.99 (3H, m), 3.13 (1H, dd, J = 13.0 Hz, 4.3 Hz), 3.45-3.49 (3H, m). 3.45-3.49 (2H, m), 3.92 (1H, m), 5.15 (1H, s), 7.27-7.33 (4H, m).

References

[1] Patent: WO2004/85408, 2004, A1. Location in patent: Page 264
[2] Bioorganic and Medicinal Chemistry Letters, 2017, vol. 27, # 16, p. 3726 - 3732

2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Preparation Products And Raw materials

Raw materials

1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-3-oxo-, 1,1-dimethylethyl ester 1,4-Dioxane Acetic acid Sodium borohydride

Preparation Products

2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER Suppliers

Global( 39)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Dayang Chem (Hangzhou) Co.,Ltd.	+86-0571-88938639 +8617705817739	info@dycnchem.com	China	52846	58
PT CHEM GROUP LIMITED	+86-85511178;	peter68@ptchemgroup.com	China	35425	58
Aladdin Scientific		tp@aladdinsci.com	United States	52923	58
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Pure Chemistry Scientific Inc.	001-857-928-2050 or 1-888-588-9418	sales@chemreagents.com	United States	10186	62
NovoChemy Ltd.	021-31261262/ 49 (0)17662837245	sales@novochemy.com	Germany	6328	58
Shanghai Hong-chuang Pharma Tech Co., Ltd.	18151128828	hc-sales@foxmail.com	China	2648	55
Aloespharm Co., Ltd.	021-20960837	market@aloespharm.com	China	1302	55
Shanghai HuanChuan Industry Co.,Ltd.	021-61478794	sales@hcshhai.com	China	9793	50

Supplier	Advantage
Alchem Pharmtech,Inc.	58
Dayang Chem (Hangzhou) Co.,Ltd.	58
PT CHEM GROUP LIMITED	58
Aladdin Scientific	58
Amadis Chemical Company Limited	58
Pure Chemistry Scientific Inc.	62
NovoChemy Ltd.	58
Shanghai Hong-chuang Pharma Tech Co., Ltd.	55
Aloespharm Co., Ltd.	55
Shanghai HuanChuan Industry Co.,Ltd.	50

769944-39-0(2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER)Related Search:

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1-Boc-2-(4-chlorophenyl)piperazine tert-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate 2-(4-CHLOROPHENYL)PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER t-Butyl 2-(4-chlorophenyl)piperazine-1-carboxylate 2-(4-chlorophenyl)-1-piperazinecarboxylic acid tert-butyl ester 1-Piperazinecarboxylic acid, 2-(4-chlorophenyl)-, 1,1-dimethylethyl ester 769944-39-0