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RAS INHIBITORY PEPTIDE

RAS INHIBITORY PEPTIDE structure

CAS No.: 159088-48-9

Chemical Name:: RAS INHIBITORY PEPTIDE

Synonyms: VPPPVPPRRR-NH2;RAS INHIBITORY PEPTIDE;Sos SH3 domain inhibitor;Sos SH3 domain inhibitor inhibitor;VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG;HSOS (1149-1158) N10 SH3 BINDING DOMAIN;H-VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG-OH;L-Arginine, L-valyl-L-prolyl-L-prolyl-L-prolyl-L-valyl-L-prolyl-L-prolyl-L-arginyl-L-arginyl-

CBNumber:: CB5356014

Molecular Formula:: C53H91N19O11

Molecular Weight:: 1170.41

MDL Number:: MFCD00237248

MOL File:: 159088-48-9.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-07-22 15:57:46

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RAS INHIBITORY PEPTIDE Properties

Density	1.52±0.1 g/cm3(Predicted)
storage temp.	−20°C
solubility	DMF: 30 mg/ml; DMSO: 30 mg/ml; Ethanol: Miscible; PBS (pH 7.2): 10 mg/ml
form	A crystalline solid
pka	3.31±0.10(Predicted)
Sequence	Val-Pro-Pro-Pro-Val-Pro-Pro-Arg-Arg-Arg

SAFETY

Risk and Safety Statements

WGK Germany	3

RAS INHIBITORY PEPTIDE price More Price(21)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	17474	Ras Inhibitory Peptide ≥95%	159088-48-9	500μg	$75	2026-04-30	Buy
Cayman Chemical	17474	Ras Inhibitory Peptide ≥95%	159088-48-9	1mg	$128	2026-04-30	Buy
Cayman Chemical	17474	Ras Inhibitory Peptide ≥95%	159088-48-9	5mg	$553	2026-04-30	Buy
Cayman Chemical	17474	Ras Inhibitory Peptide ≥95%	159088-48-9	10mg	$956	2026-04-30	Buy
Biosynth	FR108435	Ras Inhibitory Peptide	159088-48-9	2000ug	$900	2026-06-04	Buy

Product number	Packaging	Price	Buy
17474	500μg	$75	Buy
17474	1mg	$128	Buy
17474	5mg	$553	Buy
17474	10mg	$956	Buy
FR108435	2000ug	$900	Buy

RAS INHIBITORY PEPTIDE Chemical Properties, Uses, Production

Description

Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction that is essential for Ras activation by receptor tyrosine kinases, including epidermal growth factor receptor.

Uses

Ras Inhibitory Peptide (VPPPVPPRRR) is a Ras inhibitor with antitumor activity[1].

References

[1] Pei-Yin Ho, et al. Terbinafine inhibits endothelial cell migration through suppression of the Rho-mediated pathway. Mol Cancer Ther. 2006 Dec;5(12):3130-8. DOI:10.1158/1535-7163.MCT-06-0457

RAS INHIBITORY PEPTIDE Preparation Products And Raw materials

Raw materials

Preparation Products

RAS INHIBITORY PEPTIDE Suppliers

Global Suppliers ( 58)

Supplier	Tel	Email	Country	ProdList	Advantage
GL Biochem (Shanghai) Ltd	21-61263452 13641803416	ymbetter@glbiochem.com	China	9981	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15350	60
Chengdu Youngshe Chemical Co., Ltd.	+86-17380623303	Caroline@youngshechem.com	China	4726	58
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58
Shanghai Hongye Biotechnology Co. Ltd	400-9205774 400-920-5774	sales@glpbio.cn	China	6705	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	meitaochem@126.com	meitaochem@126.com	China	19087	58
Alfa Chemistry	+1-5166625404;	Info@alfa-chemistry.com	United States	20000	58
TargetMol Chemicals Inc.	+1-781-999-5354; +1-00000000000	marketing@targetmol.com	United States	32431	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	18818260767	sales@chemegen.com	China	11123	58

Supplier	Advantage
GL Biochem (Shanghai) Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky (shanghai) International Co.,Ltd	60
Chengdu Youngshe Chemical Co., Ltd.	58
Hangzhou Peptidego Biotech Co.,Ltd.	58
Shanghai Hongye Biotechnology Co. Ltd	58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.	58
Alfa Chemistry	58
TargetMol Chemicals Inc.	58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.	58

View Latest Price from RAS INHIBITORY PEPTIDE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-07-21	Ras Inhibitory Peptide 159088-48-9	$420.00-3130.00			10g	TargetMol Chemicals Inc.

Ras Inhibitory Peptide
159088-48-9
$420.00-3130.00
TargetMol Chemicals Inc.

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RAS INHIBITORY PEPTIDE VPPPVPPRRR-NH2 VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG H-VAL-PRO-PRO-PRO-VAL-PRO-PRO-ARG-ARG-ARG-OH HSOS (1149-1158) N10 SH3 BINDING DOMAIN Sos SH3 domain inhibitor L-Arginine, L-valyl-L-prolyl-L-prolyl-L-prolyl-L-valyl-L-prolyl-L-prolyl-L-arginyl-L-arginyl- Sos SH3 domain inhibitor inhibitor 159088-48-9 C53H91N19O11 BioChemical Cell Signaling and Neuroscience Cell Biology Reagents G Protein Function G Proteins and Cyclic Nucleotides