Pyrazole
- CAS No.
- 288-13-1
- Chemical Name:
- Pyrazole
- Synonyms
- 1H-PYRAZOLE;PYRAZOL;1H-Pyrazol;Pyrrazole;α-yrromonazole;Pyrazole, pure, 98%;PYRAZOLE;Ryrazole;1,2-DIAZOL;1,2-DIAZOLE
- CBNumber:
- CB6689669
- Molecular Formula:
- C3H4N2
- Molecular Weight:
- 68.08
- MDL Number:
- MFCD00005234
- MOL File:
- 288-13-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 67-70 °C (lit.) |
|---|---|
| Boiling point | 186-188 °C (lit.) |
| Density | 1.4088 (rough estimate) |
| vapor pressure | 21Pa at 20℃ |
| refractive index | 1.4203 |
| Flash point | 186-188°C |
| storage temp. | Store below +30°C. |
| solubility | Chloroform, Methanol |
| form | Crystals or Crystalline Powder |
| pka | 2.49(at 25℃) |
| color | White to yellow |
| Water Solubility | SOLUBLE |
| Specific Heat Capacity | Cp(crystal): 1.19 J/(g·K), at 25℃ |
| Sensitive | Hygroscopic |
| Merck | 14,7960 |
| BRN | 103775 |
| InChI | 1S/C3H4N2/c1-2-4-5-3-1/h1-3H,(H,4,5) |
| InChIKey | WTKZEGDFNFYCGP-UHFFFAOYSA-N |
| SMILES | c1cn[nH]c1 |
| LogP | 0.33 at 25℃ |
| CAS DataBase Reference | 288-13-1(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | 3QD5KJZ7ZJ |
| NIST Chemistry Reference | 1H-Pyrazole(288-13-1) |
| EPA Substance Registry System | Pyrazole (288-13-1) |
| UNSPSC Code | 12352100 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS05,GHS06,GHS08 |
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|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H311-H315-H318-H373-H412 | |||||||||
| Precautionary statements | P273-P280-P301+P312-P302+P352+P312-P305+P351+P338-P314 | |||||||||
| target organs | spleen,Thyroid | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38-52-20/21/22 | |||||||||
| Safety Statements | 26-36/37-61-37/39-36 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 1 | |||||||||
| RTECS | UQ4900000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29331990 | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
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| Hazard Classifications | Acute Tox. 3 Dermal Acute Tox. 4 Oral Aquatic Chronic 3 Eye Dam. 1 Skin Irrit. 2 STOT RE 1 |
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| Toxicity | LD50 (24 hr) in rats, mice (mmol/kg): 19, 21 i.v.; 21, 22 orally (Magnussen) | |||||||||
| REACH Registrations | Active | |||||||||
| Limited Quantities | 5.0 kg (11 lbs) (solid) | |||||||||
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) | |||||||||
| NFPA 704 |
|
Pyrazole price More Price(89)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P56607 | Pyrazole 98% | 288-13-1 | 5g | $19.7 | 2026-04-30 | Buy |
| Sigma-Aldrich | P56607 | Pyrazole 98% | 288-13-1 | 25g | $70.1 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.07572 | Pyrazole for synthesis | 288-13-1 | 25g | $94 | 2026-04-30 | Buy |
| TCI Chemical | P0546 | Pyrazole >98.0%(GC)(T) | 288-13-1 | 25g | $25 | 2026-04-30 | Buy |
| TCI Chemical | P0546 | Pyrazole >98.0%(GC)(T) | 288-13-1 | 250g | $65 | 2026-04-30 | Buy |
Pyrazole Chemical Properties,Uses,Production
Chemical Properties
white to yellow crystals or crystalline powder
Uses
Pyrazole is used in organic synthesis and asa chelating agent.
Definition
ChEBI: 1H-pyrazole is the 1H-tautomer of pyrazole. It is a conjugate base of a pyrazolium. It is a conjugate acid of a pyrazol-1-ide. It is a tautomer of a 3H-pyrazole and a 4H-pyrazole.
General Description
Pyrazine is a heterocyclic crystalline aromatic compound with a five-membered ring containing three carbon atoms and two nitrogen atoms. It is a symmetricdiazine.
Hazard
Toxic by ingestion and inhalation, irritant to skin and eyes.
Health Hazard
The acute toxic symptoms from oral administrationof pyrazole in experimental animalswere ataxia, muscle weakness, and respiratorydepression. It is less toxic than pyrroleand pyrrolidine. The oral LD50 value in miceis within the range 1450 mg/kg.
Pyrazole exhibited reproductive toxicityin rats and mice when administered by oralor intraperitoneal route. The effects includefetal death, developmental abnormalities pertainingto the urogenital system, and postimplantationmortality.
Fire Hazard
Noncombustible solid.
Safety Profile
Moderately toxic by ingestion and intraperitoneal routes. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Synthesis
Pyrazoles are synthesized via the condensation of hydrazines with 1,3-dicarbonyl compounds or their synthetic equivalents, as well as through 1,3-dipolar cycloaddition reactions of diazo compounds with dipolarophiles. They can also be produced by the in situ generation of nitrile imines from aromatic hydrazines and aldehydes through Oxone-KBr oxidation and base-promoted dehydrobromination, followed by cycloaddition with alkene or alkyne groups[1][2].
Purification Methods
Crystallise pyrazole from pet ether, cyclohexane, or water. Its solubility in H2O at 9.6o is 2.7moles/L, and at 24.8o it is 19.4moles/L; in cyclohexane at 31.8o it is 0.577moles/L, and at 56.2o it is 5.86moles/L; and in benzene at 5.2o it is 0.31moles/L, and at 46.5o it is 16.8moles/1000mL. [Barszcz et al. J Chem Soc, Dalton Trans 2025 1986, Beilstein 23 H 39, 23 I 15, 23 II 33, 23 III/IV 550, 23/4 V 122.]
References
[1]Chandrasekharan, S. P., Dhami, A., Kumar, S., & Mohanan, K. (2022). Recent advances in pyrazole synthesis employing diazo compounds and synthetic analogues. Organic & Biomolecular Chemistry, 20(45), 8787–8817. https://doi.org/10.1039/d2ob01918c
[2]Zhou, J., Zhou, Q., & Wan, J.-P. (2024). Recent advances in the multicomponent synthesis of pyrazoles. Organic & Biomolecular Chemistry, 22(40), 8065–8077. https://doi.org/10.1039/d4ob01211a
Pyrazole Preparation Products And Raw materials
Raw materials
Preparation Products
1of5
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Bosi Electronic Materials Co., Ltd. | 13916923354 13501880914 | 13585846964@139.com | China | 24 | 58 |
| HuBei Bass Electronic Material Co.,Ltd | 0716-0716-2852356 18971568347 | sale@basschemical.com | China | 35 | 58 |
| Yancheng Green Chemicals Co.,Ltd. | 25-86639215 18852541892 | marketing@royal-chem.com | China | 73 | 58 |
| Nanjing Dilu Pharmaceutical Co., Ltd | 18014482516 18014482516 | 977144864@qq.com | China | 424 | 58 |
| Nanjing Yili Biotechnology Co., Ltd. | 13851808754 | BUYC24@aikonchem.com | China | 8188 | 58 |
| Qingdao Haizhi Weiyuan Biotechnology Co., Ltd. | 18317699790 18317699790 | l202008112023@163.com | China | 7733 | 58 |
| HangZhou YuHao Chemical Technology Co., Ltd. | 0571-82693216 | info@yuhaochemical.com | China | 1999 | 58 |
| Creasyn Finechem(Tianjin) Co., Ltd. | 022-83946278 13820372920 | sales@creasyn.com | China | 968 | 68 |
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
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View Lastest Price from Pyrazole manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-11 | Pyrazole
288-13-1
|
$14000.00-1200000.00 | 1000kg | 99% | 500 tons | Gansu Jinyuantai New Material Co., Ltd. | |
 |
2026-09-11 | Pyrazole
288-13-1
|
$14000.00-120000.00 | 1000kg | 99% | 500 tons | Yancheng Green Chemicals Co.,Ltd | |
 |
2026-09-11 | Pyrazole
288-13-1
|
$238.00 | 1000kg | 99.5% | 100 tons | Anhui Royal Chemical Co., Ltd. |
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