Closantel
- CAS No.
- 57808-65-8
- Chemical Name:
- Closantel
- Synonyms
- CLOSANTEL BASE;Zycloz;Diantel;R-31520;Closante;CLOSANTEL;faskoverm;Krosantai;5-diiodo-y-;iodobenzamide
- CBNumber:
- CB5360606
- Molecular Formula:
- C22H14Cl2I2N2O2
- Molecular Weight:
- 663.07
- MDL Number:
- MFCD00661151
- MOL File:
- 57808-65-8.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 217.8° |
|---|---|
| Boiling point | 590.5±50.0 °C(Predicted) |
| Density | 1.8759 (estimate) |
| storage temp. | Keep in dark place,Sealed in dry,2-8°C |
| solubility | DMF: 20 mg/ml; DMSO: 20 mg/ml; DMSO:PBS (pH 7.2)(1:5): 0.16 mg/ml |
| pka | 5.99±0.48(Predicted) |
| form | Solid |
| color | White to off-white |
| Major Application |
agriculture environmental |
| InChI | 1S/C22H14Cl2I2N2O2/c1-11-6-15(17(10-27)12-2-4-13(23)5-3-12)18(24)9-20(11)28-22(30)16-7-14(25)8-19(26)21(16)29/h2-9,17,29H,1H3,(H,28,30) |
| InChIKey | JMPFSEBWVLAJKM-UHFFFAOYSA-N |
| SMILES | Cc1cc(C(C#N)c2ccc(Cl)cc2)c(Cl)cc1NC(=O)c3cc(I)cc(I)c3O |
| CAS DataBase Reference | 57808-65-8(CAS DataBase Reference) |
| FDA UNII | EUL532EI54 |
| UNSPSC Code | 41116107 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H301-H413 | |||||||||
| Precautionary statements | P273-P301+P310+P330 | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Faceshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22 | |||||||||
| RIDADR | 2811 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | CV2444250 | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| Storage Class | 6.1C - Combustible acute toxic Cat.3 toxic compounds or compounds which causing chronic effects |
|||||||||
| Hazard Classifications | Acute Tox. 3 Oral Aquatic Chronic 4 |
|||||||||
| Toxicity | A veterinary drug for the treatment of fluke and nematode infestations. In 1993, some was included in a batch of donated drugs sent to Lithuania. Attempts to match the product with the names of other medicines on accompanying literature resulted in its misidentification as a treatment for endometriosis. Eleven women lost their eyesight; though this has since returned, they were left with eye pain and are unable to work. | |||||||||
| NFPA 704 |
|
Closantel price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 34093 | Closantel PESTANAL | 57808-65-8 | 100mg | $128 | 2026-04-30 | Buy |
| TCI Chemical | C3930 | Closantel | 57808-65-8 | 1G | $41 | 2026-04-30 | Buy |
| Cayman Chemical | 20531 | Closantel ≥98% | 57808-65-8 | 50mg | $63 | 2026-04-30 | Buy |
| Cayman Chemical | 20531 | Closantel ≥98% | 57808-65-8 | 100mg | $98 | 2026-04-30 | Buy |
| Cayman Chemical | 20531 | Closantel ≥98% | 57808-65-8 | 500mg | $363 | 2026-04-30 | Buy |
Closantel Chemical Properties, Uses, Production
Description
Closantel is a kind of synthetic anti parasitic agent which is actively against liver fluke, bloodsucking nematodes and larval stages of some arthropods in sheep and cattle. Its mechanism of action is through decoupling the mitochondrial oxidative phosphorylation, thus inhibiting the production of ATP. Therefore, it inhibit their energy generation of the parasite, causing their death. It is mainly used for the treatment and prevention of several infections caused by many kinds of parasites such as Fasciola hepatica, Fasciola gigantica, Haemonchus concortus, Haemonchus placei, Bunostomum phlebotomum, Oesophagostomum radiatum and Strongyloides papillosus in cattle and sheep.
References
http://www.interchemie.com/veterinary-medicines/closan-50.html
Chemical Properties
White to light yellow powder
Uses
antianginal, antihypertensive
Definition
ChEBI: N-{5-chloro-4-[(4-chlorophenyl)(cyano)methyl]-2-methylphenyl}-2-hydroxy-3,5-diiodobenzamide is an aromatic amide resulting from the formal condensation of the carboxy group of 3,5-diiodosalicylic acid with the amino group of aniline substituted at positions 2, 4, and 5 by methyl, (4-chlorophenyl)(cyano)methyl, and methyl groups respectively. It is a nitrile, a member of phenols, an organoiodine compound, a monocarboxylic acid amide, an aromatic amide and a member of monochlorobenzenes.
Closantel Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Ningbo Taikang Chemical Co., Ltd. | 0574-87365517 18074210286 | sales@taikangchem.com | China | 294 | 58 |
| XiaoGan ShenYuan ChemPharm co,ltd | 15527621225; 15527621225 | 1791901229@qq.com | China | 6743 | 52 |
| Beijing HuaMeiHuLiBiological Chemical | 010-56205725 | waley188@sohu.com | China | 12323 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29985 | 65 |
| The future of Shanghai Industrial Co., Ltd. | 021-61552785 | sales@shshiji.com | China | 9531 | 55 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4773 | 55 |
| Nanjing Sunlida Biological Technology Co., Ltd. | 025-57798810 18652991625 | sales@sunlidabio.com | China | 3223 | 55 |
| TargetMol Chemicals Inc. | 021-021-33632979 15002134094 | marketing@targetmol.com | China | 7993 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8039 | 58 |
View Latest Price from Closantel manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-09-15 | Closantel
57808-65-8
|
$300.00 | 1kg | 99.0%min | 3tons/momth | Asia Chem I and E (Jiangsu) Co Ltd | |
 |
2026-09-01 | Closantel
57808-65-8
|
1kg | 99% | 1000kg | Shaanxi TNJONE Pharmaceutical Co., Ltd | ||
 |
2026-08-29 | Closantel
57808-65-8
|
$34.00-54.00 | 99.86% | 10g | TargetMol Chemicals Inc. |
