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ChemicalBook >> CAS DataBase List >>[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone

[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone

[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Structure
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone structure
CAS No.
727686-80-8
Chemical Name:
[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone
Synonyms
SKI-349;[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone
CBNumber:
CB53899653
Molecular Formula:
C19H19N3O4S
Molecular Weight:
385.43686
MDL Number:
MOL File:
727686-80-8.mol
MSDS File:
SDS
Last updated:2025-04-18 09:51:14
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[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Properties

form Solid
color Light yellow to yellow

[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
ChemScene CS-0954698 SKI-349 99.58% 727686-80-8 5mg $108 2026-06-04 Buy
ChemScene CS-0954698 SKI-349 99.58% 727686-80-8 10mg $173 2026-06-04 Buy
ChemScene CS-0954698 SKI-349 99.58% 727686-80-8 25mg $347 2026-06-04 Buy
ChemScene CS-0954698 SKI-349 99.58% 727686-80-8 50mg $542 2026-06-04 Buy
aablocks AA0249A1 SKI-349 >98% 727686-80-8 5mg $147 2026-06-01 Buy
Product number Packaging Price Buy
CS-0954698 5mg $108 Buy
CS-0954698 10mg $173 Buy
CS-0954698 25mg $347 Buy
CS-0954698 50mg $542 Buy
AA0249A1 5mg $147 Buy

[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Chemical Properties, Uses, Production

Description

SKI-349 is a novel dual-targeted inhibitor of sphingosine kinase and microtubule polymerization.

Uses

SKI-349 is a dual-targeted inhibitor of sphingosine kinase 1/2 (SPHK1/2) and microtubule assembly (MDA). SKI-349 has anticancer activity. SKI-349 can inhibit the vitality, invasion, and AKT/mTOR signaling pathway of liver cells[1][2].

References

[1] Hengst JA, et al. Development of SKI-349, a dual-targeted inhibitor of sphingosine kinase and microtubule polymerization. Bioorg Med Chem Lett. 2020 Oct 15;30(20):127453. DOI:10.1016/j.bmcl.2020.127453
[2] Chen L, et al. SKI-349, a Sphingosine Kinases 1/2 Inhibitor, Suppresses Cell Viability, Invasion, and AKT/mTOR Signaling Pathway, and Shows Synergistic Cytotoxic Effects with Sorafenib in Hepatocellular Carcinoma. Tohoku J Exp Med. 2023 Dec 21. DOI:10.1620/tjem.2023.J100

[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Preparation Products And Raw materials

Raw materials

Preparation Products

[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone Suppliers

Global Suppliers ( 4)
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 29874 58
Anhui JYHX CO., LTD. 055167162561 13295518198 wangyanan@ahjyhx.com China 2044 58
Zhejiang Huida Biotech Co., Ltd. 0571-89903022 18679456698 zilong@hizyme.com China 7853 58
Supplier Advantage
TargetMol Chemicals Inc. 58
Anhui JYHX CO., LTD. 58
Zhejiang Huida Biotech Co., Ltd. 58

727686-80-8 ([4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone) Related Search:

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[4-amino-2-(4-methoxyanilino)-1,3-thiazol-5-yl]-(3,4-dimethoxyphenyl)methanone SKI-349 727686-80-8