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DL-Pipecolinic acid

DL-Pipecolinic acid structure

CAS No.: 535-75-1

Chemical Name:: DL-Pipecolinic acid

Synonyms: PIPECOLIC ACID;PIPERIDINE-2-CARBOXYLIC ACID;PIPECOLINIC ACID;2-PIPERIDINECARBOXYLIC ACID;pipecolate;DL-2-Piperidinecarboxylic acid;NSC 17125;H-DL-HOPRO-OH;DL-PIPECOLATE;DL-HOMOPROLINE

CBNumber:: CB5398555

Molecular Formula:: C6H11NO2

Molecular Weight:: 129.16

MDL Number:: MFCD00064347

MOL File:: 535-75-1.mol

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-08-25 20:17:46

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DL-Pipecolinic acid Properties

Melting point	282 °C (dec.)(lit.)
Boiling point	239.22°C (rough estimate)
alpha	[α]D20 -1~+1° (c=2.5, H2O)
Density	1.1426 (rough estimate)
refractive index	1.4587 (estimate)
storage temp.	Sealed in dry,Room Temperature
solubility	Methanol (Slightly), Water (Slightly)
form	Fine Crystalline Powder
pka	2.28, 10.72(at 25℃)
color	White to light beige
Water Solubility	soluble
Merck	14,7458
BRN	81095
InChI	1S/C6H11NO2/c8-6(9)5-3-1-2-4-7-5/h5,7H,1-4H2,(H,8,9)
InChIKey	HXEACLLIILLPRG-UHFFFAOYSA-N
SMILES	OC(=O)C1CCCCN1
CAS DataBase Reference	535-75-1(CAS DataBase Reference)
EWG's Food Scores	1
FDA UNII	H254GW7PVV
EPA Substance Registry System	2-Piperidinecarboxylic acid (535-75-1)
UNSPSC Code	12352106
NACRES	NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P264-P271-P280-P302+P352-P305+P351+P338

target organs

Respiratory system

PPE

dust mask type N95 (US), Eyeshields, Gloves

Hazard Codes

Risk Statements

36/37/38

Safety Statements

26-36-24/25

WGK Germany

RTECS

TK6021000

TSCA

TSCA listed

HazardClass

IRRITANT

HS Code

29339900

Storage Class

11 - Combustible Solids

Hazard Classifications

Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

REACH Registrations

Active

NFPA 704

	0
2		0

DL-Pipecolinic acid price More Price(85)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	P45850	Pipecolinic acid 98%	535-75-1	25g	$114	2026-04-30	Buy
Sigma-Aldrich	P45850	Pipecolinic acid 98%	535-75-1	100g	$156	2026-04-30	Buy
TCI Chemical	P0442	DL-Pipecolic Acid >98.0%(T)	535-75-1	25g	$70	2026-04-30	Buy
TRC	TRC-P479760-1G	DL-Pipecolic Acid	535-75-1	1g	$192	2026-06-03	Buy
TRC	TRC-P479760-10G	DL-Pipecolic Acid	535-75-1	10g	$1482	2026-06-03	Buy

Product number	Packaging	Price	Buy
P45850	25g	$114	Buy
P45850	100g	$156	Buy
P0442	25g	$70	Buy
TRC-P479760-1G	1g	$192	Buy
TRC-P479760-10G	10g	$1482	Buy

DL-Pipecolinic acid Chemical Properties, Uses, Production

Chemical Properties

white to light beige fine crystalline powder

Uses

Pipecolic acid is involved in synaptic transmission in the central nervous system.

Uses

DL-Pipecolinic acid is used as a diagnostic marker of pyridoxine-dependent epilepsy. It acts as a ligand in copper-catalyzed approach for P-arylation of organophosphorus compounds. It is used as organocatalyst and novel substrate in organic synthesis.

Definition

ChEBI: A piperidinemonocarboxylic acid in which the carboxy group is located at position C-2.

reaction suitability

reaction type: solution phase peptide synthesis

in vivo

Pipecolic acid (intragastric administration; 250 mg/kg; 1 week) can improve diabetic retinopathy in mouse model^[2].

Animal Model:	Male wild-type C57BL/6 mice aged 8 weeks old with Diabetic retinopathy (DR)^[3]
Dosage:	250 mg/kg
Administration:	Intragastric administration; 1 week
Result:	Had positive effects on weight gain and blood sugar level in mice. Significantly reduced the ratio of retinal positive areas to whole positive areas. Regulated oxidative stress and iron metabolism.

DL-Pipecolinic acid Preparation Products And Raw materials

Raw materials

Preparation Products

C-(1-Methyl-piperidin-2-yl)-methylamine

DL-Pipecolinic acid Suppliers

Global Suppliers ( 427)

Supplier	Tel	Email	Country	ProdList	Advantage
Dalian Yongda Suli Pharma Co., Ltd.	0411-39104588 18241053670	zhen.wang@yongda-suli.com	China	26	58
Anhui Dexinjia Biopharm Co., Ltd	0531-82375893 15553111391	phoebe@jndxj.com	China	285	58
Sichuan Hainuowei Technology Co. Ltd.	13708085536 13708085536	hanovichem@163.com	China	3268	56
J & K SCIENTIFIC LTD.	18210857532 18210857532	jkinfo@jkchemical.com	China	96815	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	4006356688 18621169109	market03@meryer.com	China	40202	62
INTATRADE GmbH	+49 3493/605464	sales@intatrade.de	Germany	3563	66
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Alfa Aesar	400-6106006	saleschina@alfa-asia.com	China	30103	84
TCI (Shanghai) Development Co., Ltd.	021-67121386	Sales-CN@TCIchemicals.com	China	24512	81
ShangHai DEMO Chemical Co.,Ltd	400-021-7337 2355568890	sales@demochem.com	China	2569	57

Supplier	Advantage
Dalian Yongda Suli Pharma Co., Ltd.	58
Anhui Dexinjia Biopharm Co., Ltd	58
Sichuan Hainuowei Technology Co. Ltd.	56
J & K SCIENTIFIC LTD.	76
Meryer (Shanghai) Chemical Technology Co., Ltd.	62
INTATRADE GmbH	66
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Alfa Aesar	84
TCI (Shanghai) Development Co., Ltd.	81
ShangHai DEMO Chemical Co.,Ltd	57

View Latest Price from DL-Pipecolinic acid manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-09-18	DL-Pipecolinic acid 535-75-1	$66.00-99.00		99%	5000	HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
2026-08-21	DL-Pipecolinic acid 535-75-1	$98.00-100.00	10kg	99%	100Tons	Hebei Dangtong Import and export Co LTD
2025-04-04	DL-Pipecolinic acid 535-75-1		1KG	98%	1ton	Henan Aochuang Chemical Co.,Ltd.

DL-Pipecolinic acid
535-75-1
$66.00-99.00
99%
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD

DL-Pipecolinic acid
535-75-1
$98.00-100.00
99%
Hebei Dangtong Import and export Co LTD

DL-Pipecolinic acid
535-75-1
98%
Henan Aochuang Chemical Co.,Ltd.

DL-Pipecolinic acid Spectrum

DL-Pipecolinic acid(535-75-1)¹HNMR DL-Pipecolinic acid(535-75-1)FT-IR DL-Pipecolinic acid(535-75-1)IR DL-Pipecolinic acid(535-75-1)Raman

535-75-1 (DL-Pipecolinic acid) Related Search:

2-Picolinic acid Triacetonediamine DROPERIDOL Malic acid 3,4-Pyridinedicarboxylic acid

Hyaluronic acid Chromium picolinate Quinolinic acid Ethyl 2-(Chlorosulfonyl)acetate Folic acid

Haloperidol Pyridine-2,6-dicarboxylic acid Calconcarboxylic acid Citric acid 2,2,6,6-Tetramethyl-4-piperidinol

Piperazine-2-carboxylic acid 2,5-Pyridinedicarboxylic acid 2,6-piperidinedicarboxylic acid

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acidepipecolique acidepiperidine-carboxylique-2 alpha-pipecolinicacid dihydrobaikiane hexahydropicolinicacid LABOTEST-BB LT00847911 DL-HOMOPROLINE DL-PIPECOLONIC ACID DL-PIPERCOLINIC ACID H-DL-HOMOPRO-OH H-DL-HOPRO-OH H-DL-PIC(2)-OH Piperidine-2-carboxylic acid or DL-pipecolinic acid (+/-)-2-PIPERIDINECARBOXYLIC ACID 2-PIPERIDINECARBOXYLIC ACID RARECHEM AH CK 0177 RAC PIPERIDINE-2-CARBOXYLIC ACID (+/-)-PIPERIDINE-2-CARBOXYLIC ACID Pipecolinic acid 98% DL-Homoproline≥ 98% (Assay) DL-piperidine-2-carboxylic acid/DL-Pipecolic acid RAC PIPERIDINE-2-CARBOXYLIC ACID 98% DL-PIPECOLATE DL-PiperidinecarBoxylicAcid (±)-Piperidine-2-carboxylic acid, 2-Piperidinecarboxylic acid, Homoproline, Pipecolic acid free base (±)-Piperidine-2-carboxylic acid, DL-Homoproline, DL-Pipecolinic acid DL-Pipecolic acid/Piperidine-2-carboxylic acid (RS)-2-Piperidinecarboxylic Acid 2-Carboxypiperidine 2-Pipecolinic Acid 2-Piperidinylcarboxylic Acid NSC 17125 Piperidine-6-carboxylic Acid DL-Homoproline DL-Pipecolinic Acid (+/-)-2-Piperidinecarboxylic Acid DL-2-Piperidinecarboxylic acid DL-Pipecolinic acid DL-Pipecolinic acid, 99% 25GR DL-PipecolicAcid> Piperidine-2-carboxyL DL-PipecolinicAci DL-Pipecolinic acid USP/EP/BP piperidin-1-ium-2-carboxylate Pipecolic acid (8CI) DL-Piperidin-2-carboxylic acid DL-Pipecolic Acid, ≥ 98.0% Piperidine-2-carboxylic acid 98% GC PIPERIDINE-2-CARBOXYLIC ACID Pipecolic acid (Standard) pipecolate PIPECOLIC ACID PIPECOLINIC ACID 535-75-1 4043-97-2 Peptide Synthesis Specialty Synthesis Proline Derivatives Unnatural Amino Acid Derivatives CARBOXYLIC ACID