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3-Chloro-4-(4-methylpiperazin-1-yl)aniline

3-Chloro-4-(4-methylpiperazin-1-yl)aniline structure

CAS No.: 16154-72-6

Chemical Name:: 3-Chloro-4-(4-methylpiperazin-1-yl)aniline

Synonyms: Albb-005529;AKOS B033196;AKOS BB-7856;ASISCHEM Z03257;TIMTEC-BB SBB011555;3-chloro-4-(4-methyl-1-piperazinyl)aniline;3-Chloro-4-(4-methylpiperazin-1-yl)aniline;1-(4-AMINO-2-CHLOROPHENYL)-4-METHYLPIPERAZINE;3-chloro-4-(4-methylpiperazin-1-yl)benzenamine;BENZENAMINE, 3-CHLORO-4-(4-METHYL-PIPERAZINYL)

CBNumber:: CB5410099

Molecular Formula:: C11H16ClN3

Molecular Weight:: 225.72

MDL Number:: MFCD01951505

MOL File:: 16154-72-6.mol

MSDS File:: SDS

Last updated:2026-09-12 18:53:31

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3-Chloro-4-(4-methylpiperazin-1-yl)aniline Properties

Melting point	141 °C
Boiling point	382.1±42.0 °C(Predicted)
Density	1+-.0.06 g/cm3(Predicted)
storage temp.	2-8°C, protect from light
pka	7.54±0.42(Predicted)
Appearance	Off-white to gray Solid

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H335-H315-H319
Precautionary statements	P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P
Hazard Codes	Xi
HazardClass	IRRITANT
HS Code	2933599590

3-Chloro-4-(4-methylpiperazin-1-yl)aniline price More Price(44)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Apolloscientific	OR303155	3-Chloro-4-(4-methylpiperazin-1-yl)aniline 97%	16154-72-6	250mg	$21	2026-06-04	Buy
Apolloscientific	OR303155	3-Chloro-4-(4-methylpiperazin-1-yl)aniline 97%	16154-72-6	1g	$30	2026-06-04	Buy
Apolloscientific	OR303155	3-Chloro-4-(4-methylpiperazin-1-yl)aniline 97%	16154-72-6	5g	$117	2026-06-04	Buy
Apolloscientific	OR303155	3-Chloro-4-(4-methylpiperazin-1-yl)aniline 97%	16154-72-6	25g	$516	2026-06-04	Buy
Apolloscientific	OR303155	3-Chloro-4-(4-methylpiperazin-1-yl)aniline 97%	16154-72-6	100g	$2011	2026-06-04	Buy

Product number	Packaging	Price	Buy
OR303155	250mg	$21	Buy
OR303155	1g	$30	Buy
OR303155	5g	$117	Buy
OR303155	25g	$516	Buy
OR303155	100g	$2011	Buy

3-Chloro-4-(4-methylpiperazin-1-yl)aniline Chemical Properties, Uses, Production

Synthesis

$BUTTPARK 83\09-70$

16154-62-4

3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE

16154-72-6

General procedure for the synthesis of 1-(4-amino-2-chlorophenyl)-4-methylpiperazine from 1-(2-chloro-4-nitrophenyl)-4-methylpiperazine: 1-(2-chloro-4-nitrophenyl)-4-methylpiperazine (13.5 g, 52.8 mmol) was dissolved in methanol (200 mL) and platinum(IV) oxide (0.120 g, 0.528 mmol) was added as catalyst. The reaction system was evacuated and replaced twice with hydrogen, and then the reaction was stirred under hydrogen atmosphere for 48 hours. After completion of the reaction, the crude reaction mixture was filtered through a diatomaceous earth pad and the filter cake was washed with methanol. The filtrate was concentrated to give 1-(4-amino-2-chlorophenyl)-4-methylpiperazine as an orange solid (12 g, 100% yield). The product was characterized by 1H NMR (400 MHz, methanol-d4): δ 2.35 (s, 3H), 2.62 (br.s., 4H), 2.95 (br.s., 4H), 6.63 (dd, J = 8.53, 2.76 Hz, 1H), 6.75-6.81 (m, 1H), 6.90-6.97 (m, 1H); the mass spectra (MS ) showed m/z 226 ([M+H]+).

References

[1] Patent: WO2011/120026, 2011, A1. Location in patent: Page/Page column 35
[2] Patent: WO2016/22460, 2016, A1. Location in patent: Page/Page column 138
[3] Patent: WO2017/66428, 2017, A1. Location in patent: Page/Page column 250

3-Chloro-4-(4-methylpiperazin-1-yl)aniline Preparation Products And Raw materials

Raw materials

BUTTPARK 83\09-70 Methanol Hydrogen

Preparation Products

3-Chloro-4-(4-methylpiperazin-1-yl)aniline Suppliers

Global Suppliers ( 80)

Supplier	Tel	Email	Country	ProdList	Advantage
Wuhan Chemwish Technology Co., Ltd	86-027-67849912	sales@chemwish.com	China	35884	56
Adamas Reagent, Ltd.	400-6009262 15618770481	yhx@titansci.com	China	14098	59
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
China Langchem Inc.	0086-21-58956006		China	7798	57
Shanghai Jian Chao Chemical Technology Co., Ltd.	150-2103-5486 18017383231	983544897@qq.com	China	9335	55
Shanghai Yolne Chemical Co., Ltd.	021-62960152	934678158@qq.com	China	9886	55
Clearsynth Labs Limited	+91-22-26355700	info@clearsynth.com	India	9656	58
HBCChem, Inc.	+1-510-219-6317	sales@hbcchem.com	United States	10628	60
Bide Pharmatech Ltd.	400-164-7117 18317119277	product02@bidepharm.com	China	40000	60
Hangzhou Milestone Pharmtech Co., Ltd.	0571-82896630 18969958410	sales_hz@milestonepharmtech.com	China	4907	55

Supplier	Advantage
Wuhan Chemwish Technology Co., Ltd	56
Adamas Reagent, Ltd.	59
Shanghai Hanhong Scientific Co.,Ltd.	64
China Langchem Inc.	57
Shanghai Jian Chao Chemical Technology Co., Ltd.	55
Shanghai Yolne Chemical Co., Ltd.	55
Clearsynth Labs Limited	58
HBCChem, Inc.	60
Bide Pharmatech Ltd.	60
Hangzhou Milestone Pharmtech Co., Ltd.	55

View Latest Price from 3-Chloro-4-(4-methylpiperazin-1-yl)aniline manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-09-02	3-chloro-4-(4-methylpiperazin-1-yl)aniline 16154-72-6		20kg	99%	20 tons	Qingdao RENAS Polymer Material Co., Ltd.

3-chloro-4-(4-methylpiperazin-1-yl)aniline
16154-72-6
$0.00
99%
Qingdao RENAS Polymer Material Co., Ltd.

3-Chloro-4-(4-methylpiperazin-1-yl)aniline Spectrum

3-CHLORO-4-(4-METHYLPIPERAZIN-1-YL)ANILINE(16154-72-6)¹HNMR

16154-72-6 (3-Chloro-4-(4-methylpiperazin-1-yl)aniline) Related Search:

[4-(4-Amino-2-chloro-phenyl)-piperazin-1-yl]-(4-chloro-phenyl)-methanone 3-Chloro-4-[4-(2-chloro-benzyl)-piperazin-1-yl]-phenylamine 5-Chloro-2-(4-methyl-piperazin-1-yl)-phenylamine 2-[4-(2-Chloro-4-nitrophenyl)piperazin-1-yl]ethanol [4-(4-Amino-2-chloro-phenyl)-piperazin-1-yl]-phenyl-methanone

3-Chloro-4-[4-(thien-2-ylcarbonyl)piperazin-1-yl]aniline 1-[4-(4-Amino-2-chloro-phenyl)-piperazin-1-yl]-2-methyl-propan-1-one [4-(4-Amino-2-chloro-phenyl)-piperazin-1-yl]-(4-propoxy-phenyl)-methanone [4-(4-Amino-2-chloro-phenyl)-piperazin-1-yl]-o-tolyl-methanone 3-Chloro-4-(4-ethyl-piperazin-1-yl)-phenylamine

3-Chloro-4-(4-methylpiperazin-1-yl)aniline 3-chloro-2-(4-methylpiperazin-1-yl)aniline TIMTEC-BB SBB006244 Methanone, [4-(2-chloro-4-nitrophenyl)-1-piperazinyl](5-methyl-3-phenyl-4-isoxazolyl)- BUTTPARK 83\09-70

1of3

3-CHLORO-4-(4-METHYL-PIPERAZIN-1-YL)-PHENYLAMINE AKOS BB-7856 AKOS B033196 1-(4-AMINO-2-CHLOROPHENYL)-4-METHYLPIPERAZINE ASISCHEM Z03257 TIMTEC-BB SBB011555 BENZENAMINE, 3-CHLORO-4-(4-METHYL-PIPERAZINYL) 3-chloro-4-(4-methyl-1-piperazinyl)aniline Albb-005529 3-chloro-4-(4-methylpiperazin-1-yl)benzenamine 3-chloro-4-(4-methyl-1-piperazinyl)aniline trihydrochloride Benzenamine, 3-chloro-4-(4-methyl-1-piperazinyl)- 3-Chloro-4-(4-methylpiperazin-1-yl)benzenamine - [C28653] 3-Chloro-4-(4-methylpiperazin-1-yl)aniline 16154-72-6 C11H16ClN3 C11H16N3Cl Miscellaneous