AC2-26
- CAS No.
- 151988-33-9
- Chemical Name:
- AC2-26
- Synonyms
- CA2-26;AC2-26;Ac2-26 TFA salt;Annexin A1 (1-25);Annexin 1 (ANXA - 1, Ac 2 - 26);Annexin A1(1-25)(dephosphorylated)(human)ammonium salt;Annexin-1 (2-26) (huMan), Lipocortin-1 (2-26), Calpactin II (1-25) (dephosphorylated) (huMan), Ac2-26;Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH;Annexin A1 (1-25) (dephosphorylated) (huMan) Annexin-1 (2-26) (huMan), Lipocortin-1 (2-26), Calpactin II (1-25) (dephosphorylated) (huMan), Ac2-26;Annexin A1 (1-25) (dephosphorylated) (human) trifluoroacetate salt Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH trifluoroacetate salt
- CBNumber:
- CB5429378
- Molecular Formula:
- C141H210N32O44S
- Molecular Weight:
- 3089.43
- MDL Number:
- MFCD00792708
- MOL File:
- 151988-33-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 2847.6±65.0 °C(Predicted) |
|---|---|
| Density | 1.327±0.06 g/cm3(Predicted) |
| storage temp. | Desiccate at -20°C |
| solubility | Soluble to 1 mg/ml in PBS |
| form | Solid |
| color | White to off-white |
| Sequence | Ac-Ala-Met-Val-Ser-Glu-Phe-Leu-Lys-Gln-Ala-Trp-Phe-Ile-Glu-Asn-Glu-Glu-Gln-Glu-Tyr-Val-Gln-Thr-Val-Lys-OH |
AC2-26 price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | FA108920 | Annexin A1(1-25)(dephosphorylated)(human)ammonium salt | 151988-33-9 | 5mg | $288.25 | 2026-06-04 | Buy |
| Biosynth | FA108920 | Annexin A1(1-25)(dephosphorylated)(human)ammonium salt | 151988-33-9 | 10mg | $461.3 | 2026-06-04 | Buy |
| Biosynth | FA108920 | Annexin A1(1-25)(dephosphorylated)(human)ammonium salt | 151988-33-9 | 25mg | $749.5 | 2026-06-04 | Buy |
| Biosynth | FA108920 | Annexin A1(1-25)(dephosphorylated)(human)ammonium salt | 151988-33-9 | 50mg | $1153 | 2026-06-04 | Buy |
| Biosynth | FA108920 | Annexin A1(1-25)(dephosphorylated)(human)ammonium salt | 151988-33-9 | 100mg | $1845 | 2026-06-04 | Buy |
AC2-26 Chemical Properties, Uses, Production
Uses
Ac2-26 is the N-terminal peptide of annexin 1, and has anti-inflammatory activity. Ac2-26 induces a decrease in IKKβ protein in lysosomes by chaperone-mediated autophagy (CMA). Ac2-26 ameliorates lung ischemia-reperfusion injury. Ac2-26 also inhibits airway inflammation and hyperresponsiveness in an asthma rat model[1][2][3][4].
in vivo
Ac2-26 (1mg/kg/d, i.v. since reperfusion until day 7) reduces cardiac necrosis and cardiac inflammation in mice 24 h/48 h post I-R injury model[6].
storage
Store at -20°C
References
[1] Wang LM, et al. Annexin 1-derived peptide Ac2-26 inhibits eosinophil recruitment in vivo via decreasing prostaglandin D. Int Arch Allergy Immunol. 2011;154(2):137-48. DOI:10.1159/000320228
[2] Liu L, et al. Ac2-26 Induces IKKβ Degradation Through Chaperone-Mediated Autophagy Via HSPB1 in NCM-Treated Microglia. Front Mol Neurosci. 2018 Mar 15;11:76. DOI:10.3389/fnmol.2018.00076
[3] Gong J, et al. Ac2-26 ameliorates lung ischemia-reperfusion injury via the eNOS pathway. Biomed Pharmacother. 2019 Sep;117:109194. DOI:10.1016/j.biopha.2019.109194
[4] Luo Z, et al. Annexin-1 Mimetic Peptide Ac2-26 Suppresses Inflammatory Mediators in LPS-Induced Astrocytes and Ameliorates Pain Hypersensitivity in a Rat Model of Inflammatory Pain. Cell Mol Neurobiol. 2020 May;40(4):569-585. DOI:10.1007/s10571-019-00755-8
[5] Zheng Y, et al. Annexin A1 (Ac2-26)-dependent Fpr2 receptor alleviates sepsis-induced acute kidney injury by inhibiting inflammation and apoptosis in vivo and in vitro. Inflamm Res. 2023 Feb;72(2):347-362. DOI:10.1007/s00011-022-01640-9
[6] Qin CX, et al. Cardioprotective Actions of the Annexin-A1 N-Terminal Peptide, Ac2-26, Against Myocardial Infarction. Front Pharmacol. 2019 Apr 3;10:269. DOI:10.3389/fphar.2019.00269
AC2-26 Preparation Products And Raw materials
Raw materials
Preparation Products
AC2-26 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Shanghai Hanhong Scientific Co.,Ltd. | 021-54306202 13764082696 | info@hanhongsci.com | China | 42917 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 1010 | 55 |
| Wuxi Zhongkun Biochemical Technology Co., Ltd. | 0510-85629785 18013409632; | sales@reading-chemicals.com | China | 15165 | 58 |
| Creative Peptides | info@creative-peptides.com | United States | 6083 | 56 | |
| Nanjing Leon Biological Technology Co., Ltd. | 025-84523390 -127; 17705183659 | sales@njleonbiotech.com | China | 5501 | 55 |
| Nanjing Peptide Biotech Ltd. | 025-58361106-805 15951641583 | zhao.xu@njpeptide.com | China | 9976 | 55 |
| Chengdu Youngshe Chemical Co., Ltd. | +86-17380623303 | Caroline@youngshechem.com | China | 4725 | 58 |
| Hangzhou Peptidego Biotech Co.,Ltd. | 0571-87213919 15967184799 | Eric@peptidego.com | China | 7872 | 58 |
