Methyl 3-methylaminocrotonate
- CAS No.
- 13412-12-9
- Chemical Name:
- Methyl 3-methylaminocrotonate
- Synonyms
- Methyl 3-methylaminocrotonate;Methyl 3-methylaminocrotonate,97%;METHYL 3-(METHYLAMINO)BUT-2-ENOATE;Methyl 3-(methylamino)-2-butenoate;Methyl beta-(methylamino)crotonate;methyl (E)-3-(methylamino)but-2-enoate;3-Methylaminobut-2-enoic acid methyl ester;beta-N-methylaminocapronic acid methyl ester;2-Butenoic acid, 3-(MethylaMino)-, Methyl ester;(E)-3-(methylamino)-2-butenoic acid methyl ester
- CBNumber:
- CB5439210
- Molecular Formula:
- C6H11NO2
- Molecular Weight:
- 129.16
- MDL Number:
- MFCD00027383
- MOL File:
- 13412-12-9.mol
- MSDS File:
- SDS
| Melting point | 62-68 °C |
|---|---|
| Boiling point | 187.5±23.0 °C(Predicted) |
| Density | 0.969±0.06 g/cm3(Predicted) |
| storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C |
| form | solid |
| pka | 5.73±0.70(Predicted) |
| Appearance | White to off-white Solid |
| Water Solubility | Soluble in water at (54 g/L) (25°C), Calc. |
| InChI | 1S/C6H11NO2/c1-5(7-2)4-6(8)9-3/h4,7H,1-3H3/b5-4- |
| InChIKey | QAKYFFYZPIPLDN-PLNGDYQASA-N |
| SMILES | COC(/C=C(NC)/C)=O |
| UNSPSC Code | 12352200 |
| NACRES | NA.21 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 37/39-26 | |||||||||
| WGK Germany | WGK 3 | |||||||||
| HS Code | 29224985 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
Methyl 3-methylaminocrotonate price More Price(61)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | CVT00049 | Methyl 3-(methylamino)-2-butenoate | 13412-12-9 | 1g | $304 | 2026-04-30 | Buy |
| Apolloscientific | OR29585 | Methyl 3-(methylamino)crotonate 97% | 13412-12-9 | 1g | $21 | 2026-06-04 | Buy |
| Apolloscientific | OR29585 | Methyl 3-(methylamino)crotonate 97% | 13412-12-9 | 5g | $49 | 2026-06-04 | Buy |
| Apolloscientific | OR29585 | Methyl 3-(methylamino)crotonate 97% | 13412-12-9 | 25g | $240 | 2026-06-04 | Buy |
| Apolloscientific | OR29585 | Methyl 3-(methylamino)crotonate 97% | 13412-12-9 | 100g | $724 | 2026-06-04 | Buy |
Methyl 3-methylaminocrotonate Chemical Properties, Uses, Production
Chemical Properties
white crystalline powder
Uses
It is employed as an intermediate in the synthesis of an analogue to amlodipine, bearing a short amino polyethylene glycol chain.
Synthesis
105-45-3
74-89-5
13412-12-9
1.2 g of silica gel was added to 11.6 g (100 mmol, 1 eq.) of methyl acetoacetate. To this was added 9.25 g (120 mmol, 1.2 eq.) of methylamine solution (40% aqueous solution) and the mixture was stirred overnight. The reaction mixture was extracted with dichloromethane (DCM), dried with anhydrous magnesium sulfate (MgSO), filtered and the solvent was evaporated to give the yellow oily product methyl 3-(methylamino)but-2-enoate in 12.21 g, 95% yield.1H-NMR (CDCl, δ/ppm): 8.47 (s, NH, 1H), 4.47 (s, CH, 1H). 3.61 (s, OCH, 3H), 2.91 (d, NHCH, J = 5.22 Hz, 3H), 1.92 (s, CH, 3H).
References
[1] RSC Advances, 2015, vol. 5, # 49, p. 39193 - 39204
[2] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 8, p. 1944 - 1947
[3] Patent: WO2013/25733, 2013, A1. Location in patent: Paragraph 0402
[4] Chemical and Pharmaceutical Bulletin, 1987, vol. 35, # 12, p. 4819 - 4828
[5] Bulletin de la Societe Chimique de France, 1923, vol. <4> 33, p. 1108
Methyl 3-methylaminocrotonate Preparation Products And Raw materials
Methyl 3-methylaminocrotonate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Alfa Aesar | 400-6106006 | saleschina@alfa-asia.com | China | 30103 | 84 |
| Energy Chemical | 400-0056266 | sales8178@energy-chemical.com | China | 44850 | 61 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7545 | 61 |
| Letopharm Limited | +86-21-5821 5861 | sales@letopharm.com | China | 70 | 55 |
| Bide Pharmatech Ltd. | 400-164-7117 18317119277 | product02@bidepharm.com | China | 40000 | 60 |
| Modachem Shanghai Co., Ltd | +86 (0)21 51320687 51371369 1744605818 | China | 1576 | 58 | |
| Shanghai YuLue Chemical Co., Ltd. | 021-60345187 13671753212 | lzz841106@aliyun.com | China | 10244 | 55 |
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