PF-05089771 (tosylate)
- CAS No.
- 1430806-04-4
- Chemical Name:
- PF-05089771 (tosylate)
- Synonyms
- PF0508977;PF-05089771 (tosylate);PF-05089771 >=98% (HPLC);4-[2-(3-Amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolylbenzenesulfonamide tosylate;4-[2-(3-amino-1H-pyrazol-4-yl)-4-chlorophenoxy]-5-chloro-2-fluoro-N-4-thiazolyl-4-benzenesulfonamide, monomethylbenzenesulfonate;PF 05089771 tosylate,TTX-R,pain,Na channels,PF-05089771,neuropathy,diabetic,Sodium Channel,PF05089771,inhibit,PF 05089771,tetrodotoxin,Na+ channels,Inhibitor
- CBNumber:
- CB54666201
- Molecular Formula:
- C25H20Cl2FN5O6S3
- Molecular Weight:
- 672.5556032
- MDL Number:
- MFCD30146405
- MOL File:
- 1430806-04-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| PF-05089771 ≥98% (HPLC) | PZ0311 | 5MG | $119 |
| PF-05089771 ≥98% (HPLC) | PZ0311 | 25MG | $480 |
| PF-05089771 (tosylate) ≥98% | 24449 | 5mg | $108 |
| PF-05089771 (tosylate) ≥98% | 24449 | 10mg | $205 |
| PF-05089771 (tosylate) ≥98% | 24449 | 25mg | $428 |
| storage temp. | room temp |
|---|---|
| solubility | DMF: 33 mg/ml; DMSO: 33 mg/ml; DMSO:PBS(pH 7.2) (1:4): 0.20 mg/ml |
| form | powder |
| color | white to beige |
| InChIKey | NVKBPDYKPNYMDR-UHFFFAOYSA-N |
| SMILES | ClC1=CC(C2=C(N)NN=C2)=C(OC3=C(Cl)C=C(S(NC4=CSC=N4)(=O)=O)C(F)=C3)C=C1.CC5=CC=C(S(=O)(O)=O)C=C5 |
| FDA UNII | NG8E748OWS |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
PF-05089771 (tosylate) price More Price(25)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | PZ0311 | PF-05089771 ≥98% (HPLC) | 1430806-04-4 | 5MG | $119 | 2026-04-30 | Buy |
| Sigma-Aldrich | PZ0311 | PF-05089771 ≥98% (HPLC) | 1430806-04-4 | 25MG | $480 | 2026-04-30 | Buy |
| Cayman Chemical | 24449 | PF-05089771 (tosylate) ≥98% | 1430806-04-4 | 5mg | $108 | 2026-04-30 | Buy |
| Cayman Chemical | 24449 | PF-05089771 (tosylate) ≥98% | 1430806-04-4 | 10mg | $205 | 2026-04-30 | Buy |
| Cayman Chemical | 24449 | PF-05089771 (tosylate) ≥98% | 1430806-04-4 | 25mg | $428 | 2026-04-30 | Buy |
PF-05089771 (tosylate) Chemical Properties,Uses,Production
Description
PF-05089771 is a voltage-gated sodium channel 1.7 (Nav1.7) blocker (IC50s = 11, 16, 33, and 20 nM for 5N11S, 5A11L, 5A11S, and 5A11L Nav1.7 splice variants, respectively). It is selective for Nav1.7 over Nav1.1-1.6 and 1.8 channels (IC50s = 0.11-25 μM), L-type calcium, and KvLQT and hERG potassium channels (IC50s = ≥10 μM), as well as human and cynomolgus monkey TRPV1 receptors (IC50s = 10 and 20 μM, respectively). PF-05089771 is also 1,000-fold selective for half-inactivated over resting Nav1.7 channels, and mutation of the domain IV voltage-sensor domain (VSD4) reduces PF-05089771 potency by approximately 100-fold.
Uses
PF 05089771 tosylate is a potent, orally active and selective arylsulfonamide Nav1.7 inhibitor, with IC50 values of 11 nM, 12 nM, 13 nM, 171 nM and 8 nM for hNav1.7, cynNav1.7, dogNav1.7, ratNav1.7, and musNav1.7, respectively. PF 05089771 is under the study for pain and diabetic neuropathy[1][2].
Biochem/physiol Actions
PF-05089771 is a selective and potent inhibitor of the human voltage-gated sodium ion channel Nav1.7 with an IC50 value of 11 nM. PF-05089771 targets the voltage-sensing domain, preferentially interacting with, and stabilizing, inactivated channel conformations by interaction with the voltage-sensor domain (VSD) of Domain 4. Nav1.7 is expressed in sensory neurons and is critical for pain processing. PF-05089771 is being investigated for the treatment of chronic neuropathic pain.
storage
Desiccate at RT
References
[1] Alexandrou AJ, et al. Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release. PLoS One. 2016 Apr 6;11(4):e0152405. DOI:10.1371/journal.pone.0152405
[2] Theile JW, et al. The Selective Nav1.7 Inhibitor, PF-05089771, Interacts Equivalently with Fast and Slow Inactivated Nav1.7 Channels. Mol Pharmacol. 2016 Nov;90(5):540-548. DOI:10.1124/mol.116.105437
PF-05089771 (tosylate) Preparation Products And Raw materials
Raw materials
Preparation Products
PF-05089771 (tosylate) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6312 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; | support@targetmol.com | United States | 39037 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 9920 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
View Lastest Price from PF-05089771 (tosylate) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | PF 05089771 tosylate
1430806-04-4
|
$57.00-165.00 | 98.55% | 10g | TargetMol Chemicals Inc. |
-
- PF 05089771 tosylate
1430806-04-4
- $57.00-165.00
- 98.55%
- TargetMol Chemicals Inc.
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