6-Methylthioguanine
- CAS No.
- 1198-47-6
- Chemical Name:
- 6-Methylthioguanine
- Synonyms
- 2-Amino-6-methylthiopurine;RMA-349;NSC 29420;TIMTEC-BB SBB000228;6-Methylthioguanine;S-Methyl-6-thioguanine;S6-Methyl-6-thioguanine;Mercaptopurine Impurity 29;6-Methylthioguanine USP/EP/BP;2-AMINO-6-METHYLMERCAPTOPURINE
- CBNumber:
- CB5468494
- Molecular Formula:
- C6H7N5S
- Molecular Weight:
- 181.22
- MDL Number:
- MFCD00044701
- MOL File:
- 1198-47-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 235.5°C |
|---|---|
| Density | 1.403 (estimate) |
| refractive index | 1.4606 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) |
| form | solid |
| color | White to Off-White |
| InChI | 1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11) |
| InChIKey | YEGKYFQLKYGHAR-UHFFFAOYSA-N |
| SMILES | [H]n1cnc2c(SC)nc(N)nc12 |
| FDA UNII | QNV75HJN3A |
| UNSPSC Code | 41106305 |
| NACRES | NA.51 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H302-H315-H318-H335 | |||||||||
| Precautionary statements | P280-P301+P312+P330-P302+P352-P305+P351+P338+P310 | |||||||||
| target organs | Respiratory system | |||||||||
| PPE | dust mask type N95 (US), Eyeshields, Gloves | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-37/38-41 | |||||||||
| Safety Statements | 24/25-39-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 29335995 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| Hazard Classifications | Acute Tox. 4 Oral Eye Dam. 1 Skin Irrit. 2 STOT SE 3 |
|||||||||
| NFPA 704 |
|
6-Methylthioguanine price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A9546 | 2-Amino-6-methylmercaptopurine ≥95% | 1198-47-6 | 100mg | $139 | 2026-04-30 | Buy |
| Usbiological | 017448 | 6-Methylthioguanine | 1198-47-6 | 250mg | $496 | 2026-06-03 | Buy |
| Biosynth | FA07966 | 2-Amino-6-methylmercaptopurine | 1198-47-6 | 0.025g | $181.4 | 2026-06-04 | Buy |
| Biosynth | FA07966 | 2-Amino-6-methylmercaptopurine | 1198-47-6 | 0.05g | $290.24 | 2026-06-04 | Buy |
| Biosynth | FA07966 | 2-Amino-6-methylmercaptopurine | 1198-47-6 | 0.1g | $506.22 | 2026-06-04 | Buy |
6-Methylthioguanine Chemical Properties, Uses, Production
Chemical Properties
off-white crystalline powder
Uses
As a metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine, 6-Methylthioguanine can be used as an effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer.
Uses
2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.
Definition
ChEBI: 6-methylthioguanine is a metabolite of thioguanine, a drug used in cancer chemotherapy. It has a role as a human xenobiotic metabolite. It is a member of 2-aminopurines and a thiopurine. It is functionally related to a tioguanine.
Biochem/physiol Actions
2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.
6-Methylthioguanine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| J & K SCIENTIFIC LTD. | 18210857532 18210857532 | jkinfo@jkchemical.com | China | 96815 | 76 |
| Meryer (Shanghai) Chemical Technology Co., Ltd. | 4006356688 18621169109 | market03@meryer.com | China | 40202 | 62 |
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Chemsky (shanghai) International Co.,Ltd | 021-50135380 | shchemsky@sina.com | China | 15350 | 60 |
| Shandong Xiya Chemical Co., Ltd | 13355009207 13355009207 | 3007715519@qq.com | China | 18722 | 57 |
| Hunan Hui Bai Shi Biotechnology Co., Ltd. | 0731-85526065 13308475853 | ivy@hnhbsj.com | China | 7236 | 62 |
| Chengdu Ai Keda Chemical Technology Co., Ltd. | 4008-755-333 18080918076 | 800078821@qq.com | China | 9706 | 55 |
| Thermo Fisher Scientific | 800-810-5118 | cnchemical@thermofisher.com | China | 17752 | 75 |
| 9ding chemical ( Shanghai) Limited | 4009209199 | sales@9dingchem.com | China | 22497 | 55 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 29977 | 65 |
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