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| | 6-Methylthioguanine Basic information |
| | 6-Methylthioguanine Chemical Properties |
| Melting point | 235.5°C | | density | 1.403 (estimate) | | refractive index | 1.4606 (estimate) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | solid | | color | White to Off-White |
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ACROS
| English |
| | 6-Methylthioguanine Usage And Synthesis |
| Chemical Properties | off-white crystalline powder | | Uses | As a metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine, 6-Methylthioguanine can be used as an effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer. | | Uses | 2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding. | | Definition | ChEBI: 6-methylthioguanine is a metabolite of thioguanine, a drug used in cancer chemotherapy. It has a role as a human xenobiotic metabolite. It is a member of 2-aminopurines and a thiopurine. It is functionally related to a tioguanine. | | Biochem/physiol Actions | 2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme. |
| | 6-Methylthioguanine Preparation Products And Raw materials |
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