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| | 6-Methylthioguanine Basic information |
| | 6-Methylthioguanine Chemical Properties |
| Melting point | 235.5°C | | density | 1.403 (estimate) | | refractive index | 1.4606 (estimate) | | storage temp. | -20°C Freezer | | solubility | DMSO (Slightly), Methanol (Slightly, Sonicated) | | form | solid | | color | White to Off-White | | InChI | 1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11) | | InChIKey | YEGKYFQLKYGHAR-UHFFFAOYSA-N | | SMILES | [H]n1cnc2c(SC)nc(N)nc12 |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 24/25-39-26 | | WGK Germany | 3 | | HS Code | 29335995 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
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ACROS
| English |
| | 6-Methylthioguanine Usage And Synthesis |
| Chemical Properties | off-white crystalline powder | | Uses | As a metabolite of 2’-Deoxy-6-thio Guanosine (D281650) and 6-Thioguanine, 6-Methylthioguanine can be used as an effective immunosuppressant and anticancer agent, however chronic exposure can be mutagenic in human cells as long-term use of thiopurines was found to be associated with a significantly increased risk of various types of cancer. | | Uses | 2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding. | | Definition | ChEBI: 6-methylthioguanine is a metabolite of thioguanine, a drug used in cancer chemotherapy. It has a role as a human xenobiotic metabolite. It is a member of 2-aminopurines and a thiopurine. It is functionally related to a tioguanine. | | Biochem/physiol Actions | 2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme. |
| | 6-Methylthioguanine Preparation Products And Raw materials |
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