Vu 0364739 hydrochloride
- CAS No.
- 1244640-48-9
- Chemical Name:
- Vu 0364739 hydrochloride
- Synonyms
- VU0364739 HCl;N-[2-[1-(3-Fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]dec-8-yl]ethyl]-2-naphthalenecarboxamide;N-{2-[1-(3-fluorophenyl)-4-oxo-1,3,8-triazaspiro[4.5]decan-8-yl]ethyl}naphthalene-2-carboxamide hydrochloride
- CBNumber:
- CB54738487
- Molecular Formula:
- C26H28ClFN4O2
- Molecular Weight:
- 482.98
- MDL Number:
- MFCD19690943
- MOL File:
- 1244640-48-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
Vu 0364739 hydrochloride price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Usbiological | 257066 | VU 0364739 hydrochloride Asreported | 1244640-48-9 | 10mg | $531 | 2026-06-03 | Buy |
| Usbiological | 257066 | VU 0364739 hydrochloride Asreported | 1244640-48-9 | 50mg | $1550 | 2026-06-03 | Buy |
| ChemScene | CS-0029322 | VU 0364739 hydrochloride | 1244640-48-9 | 5mg | $554 | 2026-06-04 | Buy |
| ChemScene | CS-0029322 | VU 0364739 hydrochloride | 1244640-48-9 | 10mg | $886 | 2026-06-04 | Buy |
| ApexBio Technology | B7603 | VU 0364739 hydrochloride | 1244640-48-9 | 10mg | $636 | 2026-05-06 | Buy |
Vu 0364739 hydrochloride Chemical Properties, Uses, Production
Uses
VU 0364739 Hydrochloride is a selective, small molecule inhibitor of phopholipase D2.
Biological Activity
PLD2-selective, PH domain-targeting phospholipase D allosteric inhibitor with in vitro and in vivo efficacy.
VU0364739 is a PLD2-selective, PH domain-targeting phospholipase D allosteric inhibitor (PLD2/PLD1 IC50 = 100 nM/7.5 μM by enzymatic assay) th at selectively suppresses the cellular PLD activity in GFP-PLD2-overexpressing HEK293 cells over PMA-stimulated non-small-cell lung cancer (NSCLC) Calu-1 cells with predominant PLD1 activity (IC50 = 20 nM and 1.5 μM, respectively). VU0364739 is reported to suppress PLD2-dependent proliferation in cultures (by 56% in 48 hrs; MDA-MB-231, 10 μM) and alleviate the symptoms of DSS-induced colitis in mice in vivo (10 mg/kg i.p. qod).
in vivo
| Rats IV 1 mg/kg | Rats PO 10 mg/kg | |
| CL (mL/min/kg) | 61.5 | |
| t1/2 (h) | 1.52 | |
| Vdss (L/kg) | 8.1 | |
| plasma (ng/mL) | 39.9 | |
| brain (ng/mL) | 29 | |
IC 50
PLD2: 20 nM (IC50); PLD1: 1500 nM (IC50)
storage
Desiccate at RT
Vu 0364739 hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Vu 0364739 hydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ShangHai ChuanQian Chemcial Technique Centre | 15869524721 | 3525679403@qq.com | China | 4565 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8137 | 58 |
| cjbscvictory | 13348960310 13348960310 | 3003867561@qq.com | China | 10233 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-88590548 18698872706 | 757984502@qq.com | China | 960 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 | orders@jknbiochem.com | China | 7283 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11963 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | 13053322091 13053322091 | admin@mopaikeji.com | China | 1611 | 58 |
View Latest Price from Vu 0364739 hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-14 | VU 0364739 hydrochloride
1244640-48-9
|
$168.00-677.00 | 99.60% | 10g | TargetMol Chemicals Inc. |
-
- VU 0364739 hydrochloride
1244640-48-9
- $168.00-677.00
- 99.60%
- TargetMol Chemicals Inc.
