Chinese Japanese Germany Korea
ChemicalBook >> CAS DataBase List >>(S,R,S)-Ahpc-PEG4-alkyne

(S,R,S)-Ahpc-PEG4-alkyne

(S,R,S)-Ahpc-PEG4-alkyne Structure
(S,R,S)-Ahpc-PEG4-alkyne structure
CAS No.
2267282-21-1
Chemical Name:
(S,R,S)-Ahpc-PEG4-alkyne
Synonyms
(S,R,S)-Ahpc-PEG4-alkyne;(2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13,16-tetraoxa-3-azanonadec-18-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-[(2S)-3,3-dimethyl-2-(4,7,10,13-tetraoxahexadec-15-ynamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide
CBNumber:
CB54742695
Molecular Formula:
C34H48N4O8S
Molecular Weight:
672.83
MDL Number:
MOL File:
2267282-21-1.mol
Last updated:2026-09-12 18:53:34
Request For Quotation

(S,R,S)-Ahpc-PEG4-alkyne Properties

Boiling point 903.991±65.00 °C(Press: 760.00 Torr)(predicted)
Density 1.217±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted)
storage temp. 2-8°C
pka 14.073±0.40(predicted)
form solid
UNSPSC Code 51171641
NACRES NA.22

(S,R,S)-Ahpc-PEG4-alkyne price More Price(15)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 901851 (S,R,S)-AHPC-PEG4-Alkyne 50 mg $401.8 2025-07-31 Buy
Sigma-Aldrich 901851 (S,R,S)-AHPC-PEG4-Alkyne 50mg $243.6 2024-03-01 Buy
BroadPharm bp-44839 (S,R,S)-AHPC-CO-PEG4-propargyl 2267282-21-1 50MG $110 2026-05-24 Buy
BroadPharm bp-44839 (S,R,S)-AHPC-CO-PEG4-propargyl 2267282-21-1 100MG $210 2026-05-24 Buy
BroadPharm bp-44839 (S,R,S)-AHPC-CO-PEG4-propargyl 2267282-21-1 250MG $450 2026-05-24 Buy
Product number Packaging Price Buy
901851 50 mg $401.8 Buy
901851 50mg $243.6 Buy
bp-44839 50MG $110 Buy
bp-44839 100MG $210 Buy
bp-44839 250MG $450 Buy

(S,R,S)-Ahpc-PEG4-alkyne Chemical Properties, Uses, Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-PEG4-Alkyne enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant alkyne for click chemistry with an azide on the target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant alkyne group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reaction type: click chemistry
reagent type: ligand-linker conjugate

(S,R,S)-Ahpc-PEG4-alkyne Preparation Products And Raw materials

Raw materials

Preparation Products

(S,R,S)-Ahpc-PEG4-alkyne Suppliers

Global Suppliers ( 11)
Supplier Tel Email Country ProdList Advantage
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Shanghai Uchem Inc. 15618758386 15618758386 sales3@myuchem.com China 1994 55
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4229 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
Zhengzhou Alfa Chemical Co.,Ltd +86-18530059196 sale04@alfachem.cn China 9745 58
Zhengzhou convergence chemical co., LTD 037155153829 18003835034 3897192574@qq.com China 9982 58
Henan yingchuang 16650708709 hnyingchuang@163.com China 3977 58
Shanghai Huici Pharmaceutical Technology Co., LTD 133-31922809 19372841038 lixing@pharmahuici.com China 853 58
Shanghai Yanfen Biochemical Technology Co.,LTD 17721070236 yanfen2026@126.com China 2198 58
Xian confluore Biological Technology Co., Ltd. +86-15680926068 1924344760@confluore.cn China 3000 58
Supplier Advantage
Sigma-Aldrich 80
Shanghai Uchem Inc. 55
Xi'an Confluore Biological Technology Co., Ltd. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
Zhengzhou Alfa Chemical Co.,Ltd 58
Zhengzhou convergence chemical co., LTD 58
Henan yingchuang 58
Shanghai Huici Pharmaceutical Technology Co., LTD 58
Shanghai Yanfen Biochemical Technology Co.,LTD 58
Xian confluore Biological Technology Co., Ltd. 58

View Latest Price from (S,R,S)-Ahpc-PEG4-alkyne manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S,R,S)-AHPC-PEG4-Alkyne pictures 2025-06-07 (S,R,S)-AHPC-PEG4-Alkyne
2267282-21-1
 100mg >99.00% 100mg Xian confluore Biological Technology Co., Ltd.

2267282-21-1 ((S,R,S)-Ahpc-PEG4-alkyne) Related Search:

Protac linker 5 (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide VH 032-linker 8 E3 ligase Ligand-Linker Conjugates 7 E3 ligase Ligand-Linker Conjugates 8
E3 ligase Ligand-Linker Conjugates 5 Free Base

1of2

(2S,4R)-1-[(2S)-3,3-dimethyl-2-(4,7,10,13-tetraoxahexadec-15-ynamido)butanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-7,10,13,16-tetraoxa-3-azanonadec-18-ynoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (S,R,S)-Ahpc-PEG4-alkyne 2267282-21-1