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E3 ligase Ligand-Linker Conjugates 8

E3 ligase Ligand-Linker Conjugates 8 Structure
E3 ligase Ligand-Linker Conjugates 8 structure
CAS No.
1835705-55-9
Chemical Name:
E3 ligase Ligand-Linker Conjugates 8
Synonyms
VH032-C6-PEG3-C4-Cl;(S,R,S)-AHPC-6-2-2-6-Cl;VHL Ligand-Linker Conjugates 12;(S,R,S)-AHPC-C?-PEG?-butyl chloride;(S,R,S)-AHPC-C6-PEG3-butyl chloride;E3 ligase Ligand-Linker Conjugates 8;(S,R,S)-AHPC-C6-PEG3-butyl chloride;L-Prolinamide, N-[6-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-[(2S)-2-[6-(2-{2-[(6-chlorohexyl)oxy]ethoxy}ethoxy)hexanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide;2S,4R)-1-((S)-2-(tert-Butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-6-2-2-6-Cl, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
CBNumber:
CB14694703
Molecular Formula:
C38H59ClN4O7S
Molecular Weight:
751.42
MDL Number:
MFCD31560478
MOL File:
1835705-55-9.mol
MSDS File:
SDS
Last updated:2026-05-27 23:38:02
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E3 ligase Ligand-Linker Conjugates 8 Properties

Boiling point 924.3±65.0 °C(Predicted)
Density 1.174±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility Ethanol: 100 mg/mL (133.08 mM); DMSO: ≥ 100 mg/mL (133.08 mM)
form Oil
pka 14.08±0.40(Predicted)
color Light yellow to yellow
InChIKey MLRLOIWXHCPWFF-MEEYNGGZSA-N
SMILES ClCCCCCCOCCOCCOCCCCCC(N[C@H](C(N1[C@H](C(NCC2=CC=C(C3=C(C)N=CS3)C=C2)=O)C[C@@H](O)C1)=O)C(C)(C)C)=O
UNSPSC Code 12352101
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  Exclamation Mark (GHS07)
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P280-P301+P312-P302+P352-P305+P351+P338
WGK Germany  WGK 3
Storage Class 11 - Combustible Solids

E3 ligase Ligand-Linker Conjugates 8 price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 905380 (S,R,S)-AHPC-C6-PEG3-butyl chloride ≥95% 1835705-55-9 50mg $668 2026-04-30 Buy
Biosynth KYC70555 (S,R,S)-AHPC-C6-PEG3-butyl chloride 1835705-55-9 100mg $788 2026-06-04 Buy
Biosynth KYC70555 (S,R,S)-AHPC-C6-PEG3-butyl chloride 1835705-55-9 250mg $1480 2026-06-04 Buy
ChemScene CS-7748 (S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01% 1835705-55-9 50mg $373 2026-06-04 Buy
ChemScene CS-7748 (S,R,S)-AHPC-C6-PEG3-C4-Cl 97.01% 1835705-55-9 100mg $596 2026-06-04 Buy
Product number Packaging Price Buy
905380 50mg $668 Buy
KYC70555 100mg $788 Buy
KYC70555 250mg $1480 Buy
CS-7748 50mg $373 Buy
CS-7748 100mg $596 Buy

E3 ligase Ligand-Linker Conjugates 8 Chemical Properties, Uses, Production

Uses

Protein degrader builiding block (S,R,S)-AHPC-C6-PEG3-butyl Chloride enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel–Lindau (VHL)-recruiting ligand, a linker with both hydrophobic and hydrophilic moieties, and a pendant chloroalkane for reactivity with a nucleophilic group on a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant chloro group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.

reaction suitability

reactivity: sulfuryl reactive
reagent type: ligand-linker conjugate

E3 ligase Ligand-Linker Conjugates 8 Preparation Products And Raw materials

Raw materials

Preparation Products

E3 ligase Ligand-Linker Conjugates 8 Suppliers

Global Suppliers ( 19)
Supplier Tel Email Country ProdList Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057 3003855609@qq.com China 7717 56
Sigma-Aldrich 021-61415566 800-8193336 orderCN@merckgroup.com China 51389 80
Xi'an Confluore Biological Technology Co., Ltd. +86-156-80926068 +86-15680926068 1924344760@qq.com China 4229 58
Jilin Province Woda Biotechnology Co., Ltd. 13504435624 1927928688@qq.com China 1644 58
TargetMol Chemicals Inc. +1-781-999-5354; +1-00000000000 marketing@targetmol.com United States 32431 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11123 58
Zhengzhou convergence chemical co., LTD 037155153829 18003835034 3897192574@qq.com China 9982 58
TargetMol Chemicals Inc. 4008200310 15002144251 marketing@tsbiochem.com China 24951 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 13417589054 trendseenbio@gmail.com China 9067 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 11963 58
Supplier Advantage
Sichuan Wei Keqi Biological Technology Co., Ltd. 56
Sigma-Aldrich 80
Xi'an Confluore Biological Technology Co., Ltd. 58
Jilin Province Woda Biotechnology Co., Ltd. 58
TargetMol Chemicals Inc. 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
Zhengzhou convergence chemical co., LTD 58
TargetMol Chemicals Inc. 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58

View Latest Price from E3 ligase Ligand-Linker Conjugates 8 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
(S,R,S)-AHPC-C6-PEG3-C4-Cl pictures 2026-04-22 (S,R,S)-AHPC-C6-PEG3-C4-Cl
1835705-55-9
 $61.00-98.00 10g TargetMol Chemicals Inc.
(S,R,S)-AHPC-6-2-2-6-Cl pictures 2025-06-07 (S,R,S)-AHPC-6-2-2-6-Cl
1835705-55-9
 100mg >95.00% 100mg Xian confluore Biological Technology Co., Ltd.

1835705-55-9 (E3 ligase Ligand-Linker Conjugates 8) Related Search:

Protac linker 5 (2S,4R)-1-((S)-2-(tert-Butyl)-4-oxo-6,9,12-trioxa-3-azapentadec-14-yn-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide VH 032-linker 8 (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-carboxamide hydrochloride E3 ligase Ligand-Linker Conjugates 7
E3 ligase Ligand-Linker Conjugates 8

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E3 ligase Ligand-Linker Conjugates 8 (S,R,S)-AHPC-C6-PEG3-butyl chloride VHL Ligand-Linker Conjugates 12 VH032-C6-PEG3-C4-Cl (S,R,S)-AHPC-6-2-2-6-Cl L-Prolinamide, N-[6-[2-[2-[(6-chlorohexyl)oxy]ethoxy]ethoxy]-1-oxohexyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)- 2S,4R)-1-((S)-2-(tert-Butyl)-22-chloro-4-oxo-10,13,16-trioxa-3-azadocosanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, (S,R,S)-AHPC-6-2-2-6-Cl, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate (S,R,S)-AHPC-C?-PEG?-butyl chloride (2S,4R)-1-[(2S)-2-[6-(2-{2-[(6-chlorohexyl)oxy]ethoxy}ethoxy)hexanamido]-3,3-dimethylbutanoyl]-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}pyrrolidine-2-carboxamide (S,R,S)-AHPC-C6-PEG3-butyl chloride 1835705-55-9