DRI-C21045 (DRI C21045)
- CAS No.
- 2101765-81-3
- Chemical Name:
- DRI-C21045 (DRI C21045)
- Synonyms
- DRI-C21045;DRI-C21045 (DRI C21045);8-(4'-(4-(Methoxycarbonyl)benzamido)-[1,1'-biphenyl]-4-carboxamido)naphthalene-1-sulfonic acid;DRI C21045,Tumor Necrosis Factor Receptor,DRI-C21045,DRIC21045,Inhibitor,DRI-C-21045,TNFR,inhibit,TNF Receptor;Benzoic acid, 4-[[[4'-[[(8-sulfo-1-naphthalenyl)amino]carbonyl][1,1'-biphenyl]-4-yl]amino]carbonyl]-, 1-methyl ester
- CBNumber:
- CB54844724
- Molecular Formula:
- C32H24N2O7S
- Molecular Weight:
- 580.61
- MDL Number:
- MFCD32201050
- MOL File:
- 2101765-81-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
DRI-C21045 (DRI C21045) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Biosynth | BJD76581 | DRI-c21045 | 2101765-81-3 | 50mg | $824 | 2026-06-04 | Buy |
| Biosynth | BJD76581 | DRI-c21045 | 2101765-81-3 | 100mg | $1319 | 2026-06-04 | Buy |
| ChemScene | CS-0077584 | DRI-C21045 98.11% | 2101765-81-3 | 5mg | $63 | 2026-06-04 | Buy |
| ChemScene | CS-0077584 | DRI-C21045 98.11% | 2101765-81-3 | 10mg | $102 | 2026-06-04 | Buy |
| ChemScene | CS-0077584 | DRI-C21045 98.11% | 2101765-81-3 | 25mg | $175 | 2026-06-04 | Buy |
DRI-C21045 (DRI C21045) Chemical Properties, Uses, Production
Uses
DRI-C21045 (compound 10) is a potent and selective inhibitor of the CD40-CD40L costimulatory protein-protein interaction (PPI) with an IC50 of 0.17 μM. DRI-C21045 shows concentration-dependent inhibition of the activation of NF-κB and B cell proliferation all induced by CD40L with IC50s of 17.1 μM and 4.5 μM, respectively[1].
in vivo
DRI-C21045 (30 mg/kg; daily, s.c.; in 20% HPβCD) prolongs graft survival in a murine allogeneic skin transplant model[1].
DRI-C21045 (20-60 mg/kg; twice daily s.c.; in 20% HPβCD) inhibits alloantigen-induced T cell expansion in the draining lymph nodes (DLNs)[1].
| Animal Model: | Full-thickness ear skins from BALB/c were transplanted onto the dorsal thorax of C57BL/6[1] |
| Dosage: | 30 mg/kg |
| Administration: | Daily s.c; administered in 20% w/v hydroxypropyl-β-cyclodextrin (HPβCD) solution |
| Result: | Caused prolongation of skin allograft survival. |
References
[1] Chen J, et al. Small-Molecule Inhibitors of the CD40-CD40L Costimulatory Protein-Protein Interaction. J Med Chem. 2017 Nov 9;60(21):8906-8922. DOI:10.1021/acs.jmedchem.7b01154
[2] Bojadzic D, et, al. Toward Small-Molecule Inhibition of Protein-Protein Interactions: General Aspects and Recent Progress in Targeting Costimulatory and Coinhibitory (Immune Checkpoint) Interactions. Curr Top Med Chem. 2018;18(8):674-699. DOI:10.2174/1568026618666180531092503
DRI-C21045 (DRI C21045) Preparation Products And Raw materials
Raw materials
Preparation Products
DRI-C21045 (DRI C21045) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| MQ (shanghai) Pharmaceuticals Co., Ltd. | 13761635123 | sales@linyuepharm.com | China | 5731 | 55 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9718 | 58 |
| BOC Sciences | 16314854226; +8616314854226 | inquiry@bocsci.com | United States | 19852 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11123 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 13681763483 | product02@bidepharm.com | China | 59929 | 58 |
| TargetMol Chemicals Inc. | 4008200310 15002144251 | marketing@tsbiochem.com | China | 24951 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-025-66113011 15955137747 | cb5@aikonchem.com | China | 10354 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
View Latest Price from DRI-C21045 (DRI C21045) manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-27 | DRI-C21045
2101765-81-3
|
$43.00-132.00 | 98.10% | 10g | TargetMol Chemicals Inc. | ||
 |
2026-07-27 | DRI-C21045
2101765-81-3
|
$43.00-132.00 | 98.10% | 10g | TargetMol Chemicals Inc. |
-
- DRI-C21045
2101765-81-3
- $43.00-132.00
- 98.10%
- TargetMol Chemicals Inc.
-
- DRI-C21045
2101765-81-3
- $43.00-132.00
- 98.10%
- TargetMol Chemicals Inc.
