GSK 983)
- CAS No.
- 827591-02-6
- Chemical Name:
- GSK 983)
- Synonyms
- GSK 983);GSK983 (GSK-983;GSK983 >=98% (HPLC);2-Pyridinecarboxamide, N-[(1R)-6-chloro-2,3,4,9-tetrahydro-1H-carbazol-1-yl]-;2'-chloro-6',7'-dihydrospiro[cyclopropane-1,5'-pyrrolo[2,3-d]pyrimidine]-6'-one
- CBNumber:
- CB54844845
- Molecular Formula:
- C18H16ClN3O
- Molecular Weight:
- 325.79
- MDL Number:
- MFCD28978021
- MOL File:
- 827591-02-6.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 627.1±55.0 °C(Predicted) |
|---|---|
| Density | 1.38±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: 10mg/mL, clear |
| form | Solid |
| pka | 13.10±0.20(Predicted) |
| color | White to light yellow |
| optical activity | [α]/D +175 to +195°, c =1 in methylene chloride |
| InChI | 1S/C18H16ClN3O/c19-11-7-8-14-13(10-11)12-4-3-6-15(17(12)21-14)22-18(23)16-5-1-2-9-20-16/h1-2,5,7-10,15,21H,3-4,6H2,(H,22,23) |
| InChIKey | WJQBOBGVBBZLJU-UHFFFAOYSA-N |
| SMILES | ClC1=CC=C(NC2=C3CCC[C@H]2NC(C4=NC=CC=C4)=O)C3=C1 |
| UNSPSC Code | 51111800 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319 |
| Precautionary statements | P264-P280-P301+P312-P302+P352-P305+P351+P338-P332+P313 |
| WGK Germany | WGK 3 |
| Storage Class | 11 - Combustible Solids |
| Hazard Classifications | Acute Tox. 4 Oral Eye Irrit. 2 Skin Irrit. 2 |
GSK 983) price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1824 | GSK983 ≥98% (HPLC) | 827591-02-6 | 5 mg | $163 | 2026-04-30 | Buy |
| Biosynth | CIB59102 | GSK983 | 827591-02-6 | 10mg | $1119.6 | 2026-06-04 | Buy |
| Biosynth | CIB59102 | GSK983 | 827591-02-6 | 25mg | $1622.5 | 2026-06-04 | Buy |
| ChemScene | CS-0067974 | GSK983 99.8% | 827591-02-6 | 1mg | $162 | 2026-06-04 | Buy |
| ChemScene | CS-0067974 | GSK983 99.8% | 827591-02-6 | 5mg | $471 | 2026-06-04 | Buy |
GSK 983) Chemical Properties, Uses, Production
Description
GSK983 is a potent broad-spectrum antiviral. It blocks cell proliferation and dengue virus replication by inhibiting the pyrimidine biosynthesis enzyme dihydroorotate dehydrogenase (DHODH).
Uses
GSK983 is a broad-spectrum antiviral agent. GSK983 inhibits the replication of adenovirus-5 (Ad-5) and polyoma virus SV40. GSK983 inhibits the growth of cell lines immortalized by EBV, HTLV1, HPV. GSK983 induces the expression of interferon-stimulated genes[1].
References
[1] Harvey R,et al. GSK983: a novel compound with broad-spectrum antiviral activity. Antiviral Res. 2009 Apr;82(1):1-11. DOI:10.1016/j.antiviral.2008.12.015
GSK 983) Preparation Products And Raw materials
Raw materials
Preparation Products
GSK 983) Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 | marketing@energy-chemical.com | China | 44871 | 58 |
| Beijing Biocreative Technology Co., Ltd. | 15522676233 | 3007606172@qq.com | China | 1246 | 58 |
| Nanjing Shizhou Biology Technology Co.,Ltd | 025-85560043 15850508050 | cindy.huang@synzest.com | China | 11975 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 29874 | 58 |
| Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd. | 025-66061636 19370895928 | qqyang@aikonchem.com | China | 9995 | 58 |
| Zhejiang Huida Biotech Co., Ltd. | 0571-89903022 18679456698 | zilong@hizyme.com | China | 7853 | 58 |
| Guangzhou Ruidi Biotechnology Co., Ltd. | 020-82099279 18988941402 | sales@ubiochem.com | China | 9998 | 58 |
| TargetMol Chemicals Inc. | 13564774135 | marketing@targetmol.com | United States | 19950 | 58 |
