Oxolamine
- CAS No.
- 959-14-8
- Chemical Name:
- Oxolamine
- Synonyms
- 683M;683 M;Bredon;AF-438;OXOLAMINE;Ossolamina;BRN 0527181;Oxolamine (base and/or unspecified salts);5-[2-(diethylamino)ethyl]-3-phenyl-1,2,4-oxadiazole;1,2,4-OXADIAZOLE,5-(2-DIETHYLAMINO)ETHYL)-3-PHENYL-
- CBNumber:
- CB5491924
- Molecular Formula:
- C14H19N3O
- Molecular Weight:
- 245.32
- MDL Number:
- MFCD00866857
- MOL File:
- 959-14-8.mol
- MSDS File:
- SDS
| Melting point | 25°C |
|---|---|
| Boiling point | bp0.4 127° |
| Density | 1.0516 (rough estimate) |
| refractive index | 1.5310 (estimate) |
| pka | 9.40±0.25(Predicted) |
| form | Liquid |
| LogP | 2.393 |
| CAS DataBase Reference | 959-14-8(CAS DataBase Reference) |
| FDA UNII | 90BEA145GY |
| ATC code | R05DB07 |
SAFETY
Risk and Safety Statements
| Toxicity | LD50 oral in rat: > 2gm/kg |
|---|---|
| REACH Registrations | Active |
Oxolamine Chemical Properties, Uses, Production
Originator
Bredon,Organon
Uses
Oxolamine is a antiinflammatory drug used as a cough suppressant.
Definition
ChEBI: N,N-diethyl-2-(3-phenyl-1,2,4-oxadiazol-5-yl)ethanamine is an oxadiazole and a ring assembly.
Manufacturing Process
18.7 g 3-chloro-propionyl chloride in 50 ml of dry ether was added dropwise with stirring to the cooled with ice solution 40 g of N-hydroxybenzamidine in 450 ml dry ester. A dense precipitate had fallen. The mixture was stirred 0.5 hour at room temperature and then was filtered off. The precipitate was thoroughly washed with water for a removal hydrochloride of starting Nhydroxybenzamidine whereas N-(amino)phenylmethylene-3-Cl-propionamide didnt solve. It was dried in vacuum over P2O5. Yield of clean product 94% from theoretical. MP: 98°-99°C. The solution of 9.2 g diethyl amine in 50 ml dry benzene was added dropwise to a suspension of above prepared N(amino)phenylmethylene-3-Cl-propionamide in dry benzene with stirring and cooling.
The mixture was warmed and stirred else 2 hours after adding. Then it was cooled, washed two times with water and dried over CaCl2. Then the solvent was removed. The residue was distilled in vacuum. Diethyl-[2-(3phenyl[1,2,4]oxadiasol-5)ethyl]amine (oxolamine) had BP: 127°C/0.4 mm. Yield 10.5 g.
Therapeutic Function
Antitussive, Antiinflammatory
Safety Profile
Moderately toxic by ingestion and subcutaneous routes. When heated to decomposition it emits toxic fumes of NOx.
Oxolamine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| China Langchem Inc. | 0086-21-58956006 | China | 7798 | 57 | |
| BioPharmaMatrix,Inc. | 0510-86010668 13395169561; | sales@biopharmamatrix.com | China | 5017 | 55 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131885 | 58 |
| Shaanxi Jiandu Pharmaceutical Chemical Co. Ltd. | 029-88380327 17691182729 | 1053@dideu.com | China | 2001 | 58 |
| Aishilun biotechnology (Shanghai) co., LTD | 021-50676523 18019098996 | info@acelybio.com | China | 3950 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +1-00000000000 | marketing@targetmol.com | United States | 32431 | 58 |
| Xi'an MC Biotech, Co., Ltd. | 029-89275612 +8618991951683 | mcbio_sales@163.com | China | 2240 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418671 +86-189 4982 3763 | sales@tnjchem.com | China | 34526 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +86-15350571055 | Sibel@chuanghaibio.com | China | 8737 | 58 |
