3-Hydroxybenzamide
- CAS No.
- 618-49-5
- Chemical Name:
- 3-Hydroxybenzamide
- Synonyms
- m-Hydroxybenzamide;3-Hydroxybenzamide;3- Hydroxy benzomide;BenzaMide, 3-hydroxy-;Benzamide, 3-hydroxy- (9CI);Deferasirox 3-Hydroxy benzamide Impurity;1-phenyl-5-(4-phenylphenyl)-3-pyrazolecarboxylic acid methyl ester
- CBNumber:
- CB5495058
- Molecular Formula:
- C7H7NO2
- Molecular Weight:
- 137.14
- MDL Number:
- MFCD00017572
- MOL File:
- 618-49-5.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Melting point | 170 °C |
|---|---|
| Boiling point | 318.3±25.0 °C(Predicted) |
| Density | 1.449 g/cm3 |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | soluble in Methanol |
| form | powder to crystal |
| pka | 9.26±0.10(Predicted) |
| color | White to Light yellow |
| FDA UNII | 75X4NC5TNX |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H335-H319 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P-P264-P270-P301+P312-P330-P501 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36 | |||||||||
| Safety Statements | 26 | |||||||||
| HS Code | 2924.29.7790 | |||||||||
| NFPA 704 |
|
3-Hydroxybenzamide price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | H1643 | 3-Hydroxybenzamide | 618-49-5 | 1G | $91 | 2026-04-30 | Buy |
| TCI Chemical | H1643 | 3-Hydroxybenzamide | 618-49-5 | 5G | $275 | 2026-04-30 | Buy |
| Biosynth | FH70985 | 3-Hydroxybenzamide | 618-49-5 | 5g | $150 | 2026-06-04 | Buy |
| Biosynth | FH70985 | 3-Hydroxybenzamide | 618-49-5 | 2g | $150 | 2026-06-04 | Buy |
| Biosynth | FH70985 | 3-Hydroxybenzamide | 618-49-5 | 1g | $150 | 2026-06-04 | Buy |
3-Hydroxybenzamide Chemical Properties, Uses, Production
Synthesis
873-62-1
618-49-5
General procedure for the synthesis of 3-hydroxybenzamide from 3-hydroxybenzonitrile: 3-cyanophenol (295 mg, 2.48 mmol, 100 mol%) and sodium perborate tetrahydrate (NaBO3-4H2O, 1146 mg, 7.45 mmol, 300 mol%) were dissolved in water (8 mL) and heated to 50 °C. Methanol (14 mL) was then added slowly until the mixture became clear. The reaction mixture was stirred continuously at 50 °C for 70 hours. After completion of the reaction, excess methanol was removed by evaporation. The pH of the remaining mixture was adjusted with dilute hydrochloric acid (aq) to 5. Extraction was carried out with dichloromethane (12 mL) and ethyl acetate (5 x 15 mL). The organic phases were combined, washed with brine (25 mL) and dried over anhydrous sodium sulfate (Na2SO4). After filtration, the solvent was evaporated to give the target product, 3-hydroxybenzamide (49a), as a spectroscopically pure white solid (183 mg, 54% yield): melting point 165-168 °C; thin-layer chromatography Rf value (50% ethyl acetate/hexane) 0.10.
References
[1] RSC Advances, 2015, vol. 5, # 16, p. 12152 - 12160
[2] Tetrahedron, 1989, vol. 45, # 11, p. 3299 - 3306
[3] ChemMedChem, 2010, vol. 5, # 2, p. 213 - 231
[4] Patent: WO2008/129129, 2008, A1. Location in patent: Page/Page column 66
3-Hydroxybenzamide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nanjing Chemlin Chemical Co., Ltd | 025-83697070 13770331960 | info@chemlin.com.cn | China | 16305 | 64 |
| Syntechem Co.,Ltd | info@syntechem.com | China | 12973 | 57 | |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1997 | 58 |
| Hangzhou Sage Chemical Co., Ltd. | +86057186818502 13588463833 | info@sagechem.com | China | 10265 | 58 |
| Shanghai T&W Pharmaceutical Co., Ltd. | +86 21 61551611 | China | 9874 | 58 | |
| Nanjing Norris-Pharm Technology Co., Ltd | 13901585132 | sales@norris-pharm.com | China | 8869 | 55 |
| Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. | 025-66113011 13913916777 | cfzhang@aikonchem.com | China | 19902 | 55 |
| TOKYO CHEMICAL INDUSTRY CO., LTD. | 03-36680489 | Sales-JP@TCIchemicals.com | Japan | 28364 | 80 |
| TCI Europe | 320-37350700 | sales@tcieurope.eu | Europe | 23654 | 75 |
| TCI AMERICA | 800-4238616 | sales@tciamerica.com | Americas | 23636 | 75 |
