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JKC-363

JKC-363 structure

CAS No.: 436083-30-6

Chemical Name:: JKC-363

Synonyms: JKC-363;JKC 363 TFA;(DeaMino-Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide;(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide;(DEAMINO-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE;MPR-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;(Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide, JKC-363;(DEAMINO-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE;3-MERCAPTOPROPIONYL-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;(Deamino-Cys11,D-2-Nal1?,Cys1?)-β-MSH (11-22) amide trifluoroacetate salt

CBNumber:: CB5496444

Molecular Formula:: C69H91N19O16S2

Molecular Weight:: 1506.71

MDL Number:: MFCD06636638

MOL File:: Mol file

MSDS File:: SDS

TDS File:: TDS

Last updated:2026-06-30 17:22:44

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JKC-363 Properties

Density	1.56±0.1 g/cm3(Predicted)
storage temp.	-15°C
form	Powder
pka	4.07±0.10(Predicted)
color	White to off-white
Water Solubility	Soluble to 1 mg/ml in water
Sequence	{Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8)

SAFETY

Risk and Safety Statements

Safety Statements	22-24/25

JKC-363 price More Price(22)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Usbiological	255555	JKC 363 Asreported	436083-30-6	500ug	$395	2026-06-03	Buy
Biosynth	FD109414	(Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt	436083-30-6	2000ug	$900	2026-06-04	Buy
Biosynth	FD109414	(Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt	436083-30-6	1000ug	$900	2026-06-04	Buy
Biosynth	FD109414	(Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt	436083-30-6	500ug	$900	2026-06-04	Buy
Biosynth	FD109414	(Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt	436083-30-6	5000ug	$1650	2026-06-04	Buy

Product number	Packaging	Price	Buy
255555	500ug	$395	Buy
FD109414	2000ug	$900	Buy
FD109414	1000ug	$900	Buy
FD109414	500ug	$900	Buy
FD109414	5000ug	$1650	Buy

JKC-363 Chemical Properties, Uses, Production

Uses

JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2].

IC 50

MC4R

References

[1] Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282. DOI:10.1046/j.1365-2826.2002.00769.x
[2] Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132. DOI:10.1016/j.ejphar.2003.09.017

JKC-363 Preparation Products And Raw materials

Raw materials

Preparation Products

JKC-363 Suppliers

Global Suppliers ( 60)

Supplier	Tel	Email	Country	ProdList	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	18930552037	3bsc@sina.com	China	15813	69
Nanjing Chemlin Chemical Co., Ltd	025-83697070 13770331960	info@chemlin.com.cn	China	16305	64
Shanghai Hanhong Scientific Co.,Ltd.	021-54306202 13764082696	info@hanhongsci.com	China	42917	64
Chemsky（shanghai）International Co.,Ltd.	021-50135380	shchemsky@sina.com	China	32273	50
BOC Sciences	1-631-485-4226; 16314854226	info@bocsci.com	United States	9920	65
Shanghai YuanYe Biotechnology Co., Ltd.	15026964105	2881489226@qq.com	China	89667	60
Shanghai Chaolan Chemical Technology Center	QQ：65489617 13301690235	Sales@ATKchemical.com	China	9699	58
Nanjing Leon Biological Technology Co., Ltd.	025-84523390 -127; 17705183659	sales@njleonbiotech.com	China	5501	55
Nanjing Peptide Biotech Ltd.	025-58361106-805 15951641583	zhao.xu@njpeptide.com	China	9976	55
Hangzhou Peptidego Biotech Co.,Ltd.	0571-87213919 15967184799	Eric@peptidego.com	China	7872	58

Supplier	Advantage
3B Pharmachem (Wuhan) International Co.,Ltd.	69
Nanjing Chemlin Chemical Co., Ltd	64
Shanghai Hanhong Scientific Co.,Ltd.	64
Chemsky（shanghai）International Co.,Ltd.	50
BOC Sciences	65
Shanghai YuanYe Biotechnology Co., Ltd.	60
Shanghai Chaolan Chemical Technology Center	58
Nanjing Leon Biological Technology Co., Ltd.	55
Nanjing Peptide Biotech Ltd.	55
Hangzhou Peptidego Biotech Co.,Ltd.	58

View Latest Price from JKC-363 manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2026-06-30	JKC-363 436083-30-6		1KG	98%	20Tons	Shaanxi Dideu New Materials Co. Ltd

JKC-363
436083-30-6
98%
Shaanxi Dideu New Materials Co. Ltd

436083-30-6 (JKC-363) Related Search:

BETA-MSH, HUMAN D-Prolinamide, N-acetyl-L-norleucyl-L-α-aspartyl-L-prolyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophyl-L-lysyl-D-valyl-, (2→7)-lactam Tetracosactide acetate ALPHA-MSH Msg 606

JNJ-10229570

1of2

(Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt 3-MERCAPTOPROPIONYL-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2 JKC-363 [DEAMINO-CYS11, B-(2-NAPHTHYL)-D-ALA14, CYS18]-BETA-MELANOCYTE STIMULATING HORMONE AMIDE FRAGMENT 11-22 (DEAMINO-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE (DEAMINO-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE MPR-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2 [Deamino-Cys11, β-(2-Naphthyl)-D-Ala14, Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22 Mpr-Glu-His-D-Nal(2)-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge Mpr1-Cys8) (DeaMino-Cys11,D-2-Nal14,Cys18)-b-MSH (11-22) aMide L-α-Asparagine, N-(3-mercapto-1-oxopropyl)-L-α-glutamyl-L-histidyl-3-(2-naphthalenyl)-D-alanyl-L-arginyl-L-tryptophylglycyl-L-cysteinyl-L-prolyl-L-prolyl-L-lysyl-, cyclic (1→7)-disulfide (Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide, JKC-363 (Deamino-Cys11,D-2-Nal14,Cys18)-β-MSH (11-22) amide (Deamino-Cys11,D-2-Nal1?,Cys1?)-β-MSH (11-22) amide trifluoroacetate salt (Deamino-Cys??,D-2-Nal??,Cys??)-β-MSH (11-22) amide trifluoroacetate salt Mpr-Glu-His-D-2-Nal-Arg-Trp- Gly-Cys-Pro-Pro-Lys-Asp-NH2(Disulfide bond Mpr1-Cys8) JKC 363 TFA {Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8) 436083-30-6 C69H91N19O16S2