| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
JKC-363 manufacturers
- JKC-363
-
-
2026-06-30
- CAS:436083-30-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 20Tons
|
| | JKC-363 Basic information |
| Product Name: | JKC-363 | | Synonyms: | (Deamino-Cys11,D-2-Nal 14,Cys18)-b-MSH (11-22) amide trifluoroacetate salt;3-MERCAPTOPROPIONYL-GLU-HIS-D-2-NAL-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;JKC-363;[DEAMINO-CYS11, B-(2-NAPHTHYL)-D-ALA14, CYS18]-BETA-MELANOCYTE STIMULATING HORMONE AMIDE FRAGMENT 11-22;(DEAMINO-CYS11,D-2-NAL14,CYS18)-BETA-MSH (11-22) AMIDE;(DEAMINO-CYS11,D-ALA(2-NAPHTHYL)14,CYS18)-BETA-MSH (11-22) AMIDE;MPR-GLU-HIS-D-NAL(2)-ARG-TRP-GLY-CYS-PRO-PRO-LYS-ASP-NH2;[Deamino-Cys11, β-(2-Naphthyl)-D-Ala14, Cys18]-β-Melanocyte Stimulating Hormone Amide Fragment 11-22 | | CAS: | 436083-30-6 | | MF: | C69H91N19O16S2 | | MW: | 1506.71 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | JKC-363 Chemical Properties |
| density | 1.56±0.1 g/cm3(Predicted) | | storage temp. | -15°C | | form | Powder | | pka | 4.07±0.10(Predicted) | | color | White to off-white | | Water Solubility | Soluble to 1 mg/ml in water | | Sequence | {Mpa}-Glu-His-{D-2-Nal}-Arg-Trp-Gly-Cys-Pro-Pro-Lys-Asp-NH2 (Disulfide bridge:Mpa1-Cys8) |
| | JKC-363 Usage And Synthesis |
| Uses | JKC363, a selective melanocortin MC4 receptor antagonist, has a 90-fold higher affinity at the MC4 receptor (IC50=0.5 nM) than at the MC3 receptor (44.9 nM). JKC-363 blocks the stimulatory effect of α-MSH on TRH release. Anti-hyperalgesic effect[1][2]. | | IC 50 | MC4R | | References | [1] Kim MS, et al. Effects of melanocortin receptor ligands on thyrotropin-releasing hormone release: evidence for the differential roles of melanocortin 3 and 4 receptors. J Neuroendocrinol. 2002;14(4):276-282. DOI:10.1046/j.1365-2826.2002.00769.x
[2] Bellasio S, et al. Melanocortin receptor agonists and antagonists modulate nociceptive sensitivity in the mouse formalin test. Eur J Pharmacol. 2003;482(1-3):127-132. DOI:10.1016/j.ejphar.2003.09.017 |
| | JKC-363 Preparation Products And Raw materials |
|