GW8510
- CAS No.
- 222036-17-1
- Chemical Name:
- GW8510
- Synonyms
- GW-8510 (GW8510;4-(((7-Oxo-6,7-dihydro-8H-thiazolo[5,4-e]indol-8-ylidene)methyl)amino)-N-(pyridin-2-yl)benzenesulfonamide;4-{[(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-n-(2-pyridyl)benzenesulfonamide;Benzenesulfonamide, 4-[[(6,7-dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinyl-
- CBNumber:
- CB5498145
- Molecular Formula:
- C21H15N5O3S2
- Molecular Weight:
- 449.51
- MDL Number:
- MFCD03452930
- MOL File:
- 222036-17-1.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| GW 8510 ≥98% | 43576 | 5mg | $116 |
| GW 8510 ≥98% | 43576 | 10mg | $208 |
| GW 8510 ≥98% | 43576 | 25mg | $434 |
| GW 8510 ≥98% | 43576 | 50mg | $693 |
| GW8510 99.04% | CS-0045286 | 5mg | $130 |
| Density | 1.635±0.06 g/cm3(Predicted) |
|---|---|
| storage temp. | room temp |
| solubility | DMSO: soluble |
| form | solid |
| pka | 8.39±0.10(Predicted) |
| color | Light yellow to yellow |
| InChI | InChI=1S/C21H15N5O3S2/c27-21-15(19-16(25-21)8-9-17-20(19)30-12-24-17)11-23-13-4-6-14(7-5-13)31(28,29)26-18-3-1-2-10-22-18/h1-12,23H,(H,22,26)(H,25,27) |
| InChIKey | GCYXEGSPUDSZJY-UHFFFAOYSA-N |
| SMILES | C1(S(NC2=NC=CC=C2)(=O)=O)=CC=C(NC=C2C3=C4SC=NC4=CC=C3NC2=O)C=C1 |
| UNSPSC Code | 12352202 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| PPE | Eyeshields, Gloves, type N95 (US) |
|---|---|
| WGK Germany | 3 |
| Storage Class | 11 - Combustible Solids |
GW8510 price More Price(31)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 43576 | GW 8510 ≥98% | 222036-17-1 | 5mg | $116 | 2026-04-30 | Buy |
| Cayman Chemical | 43576 | GW 8510 ≥98% | 222036-17-1 | 10mg | $208 | 2026-04-30 | Buy |
| Cayman Chemical | 43576 | GW 8510 ≥98% | 222036-17-1 | 25mg | $434 | 2026-04-30 | Buy |
| Cayman Chemical | 43576 | GW 8510 ≥98% | 222036-17-1 | 50mg | $693 | 2026-04-30 | Buy |
| ChemScene | CS-0045286 | GW8510 99.04% | 222036-17-1 | 5mg | $130 | 2026-06-04 | Buy |
GW8510 Chemical Properties,Uses,Production
Uses
GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities[1][2][3].
Definition
ChEBI: 4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide is a sulfonamide and a member of benzenes.
Biochem/physiol Actions
Initially characterized as an inhibitor of cyclin-dependent kinase 2 (CDK2), subsequent research has shown GW8510 to be non-selective.
in vivo
Combination with GW8510 and Tamoxifen enhances tumoricidal effect on Tamoxifen-resistant BBC xenograft through autophagy induction[3].
IC 50
CDK2; CDK5; RRM2
References
[1] ARCAMONE F, et, al. STRUCTURE AND SYNTHESIS OF DISTAMYCIN A. Nature. 1964 Sep 5;203:1064-5. DOI:10.1038/2031064a0
[2] Hiraku Y, et, al. Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis. Nucleic Acids Res Suppl. 2002;(2):95-6. DOI:10.1093/nass/2.1.95
[3] Majumder P, et, al. Effect of DNA groove binder distamycin A upon chromatin structure. PLoS One. 2011;6(10):e26486. DOI:10.1371/journal.pone.0026486
GW8510 Preparation Products And Raw materials
Raw materials
Preparation Products
GW8510 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32466 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 19956 | 58 |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | 024-88590548 18698872706 | 757984502@qq.com | China | 962 | 58 |
| Shanghai Topbiochem Technology Co., Ltd | 021-58170097 | info@topbiochem.com | China | 9520 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51395 | 80 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9804 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 13636370518 | shyysw007@163.com | China | 89686 | 60 |
