4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
- CAS No.
- 1353224-53-9
- Chemical Name:
- 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
- Synonyms
- CMS-121;CMS-121, 10 mM in DMSO;4-(4-(cyclopentyloxy)quinolin-2-yl)be;1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;4-(4-(cyclopentyloxy)quinolin-2-yl)be nzene-1,2-diol (CMS121);ACC, Acetyl Coenzyme A Carboxylase,disease,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoA Carboxylase,CMS 121,dementia,ACC1,CMS-121
- CBNumber:
- CB55540825
- Molecular Formula:
- C20H19NO3
- Molecular Weight:
- 321.37
- MDL Number:
- MFCD22192465
- MOL File:
- 1353224-53-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| CMS121 | 27085 | 5mg | $116 |
| 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol | 27085 | 25mg | $456 |
| CMS121 | 27085 | 1mg | $32 |
| CMS121 | 27085 | 10mg | $214 |
| CMS-121 ≥99.0% | CS-0119097 | 5mg | $300 |
| Boiling point | 511.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.297±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 20 mg/ml |
| form | A crystalline solid |
| pka | 8.53±0.20(Predicted) |
| color | Light yellow to yellow |
| InChI | InChI=1S/C20H19NO3/c22-18-10-9-13(11-19(18)23)17-12-20(24-14-5-1-2-6-14)15-7-3-4-8-16(15)21-17/h3-4,7-12,14,22-23H,1-2,5-6H2 |
| InChIKey | OMHNVUCFPJJLKD-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(C2C=C(OC3CCCC3)C3C(N=2)=CC=CC=3)C=C1O |
| FDA UNII | BW9P9F8JEY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27085 | CMS121 | 1353224-53-9 | 5mg | $116 | 2024-03-01 | Buy |
| Cayman Chemical | 27085 | 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol | 1353224-53-9 | 25mg | $456 | 2024-03-01 | Buy |
| Cayman Chemical | 27085 | CMS121 | 1353224-53-9 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 27085 | CMS121 | 1353224-53-9 | 10mg | $214 | 2024-03-01 | Buy |
| ChemScene | CS-0119097 | CMS-121 ≥99.0% | 1353224-53-9 | 5mg | $300 | 2021-12-16 | Buy |
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Chemical Properties,Uses,Production
Uses
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].
in vivo
CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1].
| Animal Model: | Female SAMP8 mice (9 months old)[1] |
| Dosage: | ~20 mg/kg/day |
| Administration: | Oral administration; daily; for 4 months |
| Result: | Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. |
References
[1] Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866. DOI:10.7554/eLife.47866
[2] Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89. DOI:10.1021/jm2012563
[3] Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13. DOI:10.1021/cn500051h
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Xi an Biohorlden Industry Trade Co Ltd | +86-18829283179 +86-13636819721 | sales@horlden.com | China | 334 | 58 |
| Shaanxi Xianhe Biotech Co., Ltd | +86-17709210191; +8617709210191 | Jerry@xhobio.com | China | 906 | 58 |
| ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD | +86-13017695106 +86-13676922317 | jiuyitime@fdachem.com | China | 16513 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354; +17819995354 | marketing@targetmol.com | United States | 32467 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Dingwang Technology (Wuhan) Co., Ltd. | +undefined-27-2786652399 +undefined13627115097 | market02@senwayer.com | China | 888 | 58 |
| Shaanxi LonierHerb Bio Technology Co Ltd | +86-86-+86-86-029-87551862 +8617702909819 | 1713330907@QQ.com | China | 2639 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52923 | 58 | |
| Shandong Xuhuang New material CoLTD | +86-15095020839 +86-17660422208 | China | 726 | 58 |
View Lastest Price from 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-04-24 | CMS-121
1353224-53-9
|
US $0.00-0.00 / bag | 1bag | 98% | 1000 | Xi an Biohorlden Industry Trade Co Ltd | |
 |
2026-04-23 | 4-(4-(cyclopentyloxy)quinolin-2- yl)benzene-1,2-diol (CMS121)
1353224-53-9
|
US $0.00 / KG | 1KG | 0.99 | 1000KG | Shaanxi Xianhe Biotech Co., Ltd | |
 |
2026-04-22 | CMS-121
1353224-53-9
|
US $61.00-178.00 / mg | 99.48% | 10g | TargetMol Chemicals Inc. |
-
- CMS-121
1353224-53-9
- US $0.00-0.00 / bag
- 98%
- Xi an Biohorlden Industry Trade Co Ltd
-
- 4-(4-(cyclopentyloxy)quinolin-2- yl)benzene-1,2-diol (CMS121)
1353224-53-9
- US $0.00 / KG
- 0.99
- Shaanxi Xianhe Biotech Co., Ltd
-
- CMS-121
1353224-53-9
- US $61.00-178.00 / mg
- 99.48%
- TargetMol Chemicals Inc.
