4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
- CAS No.
- 1353224-53-9
- Chemical Name:
- 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
- Synonyms
- CMS-121;CMS-121, 10 mM in DMSO;4-(4-(cyclopentyloxy)quinolin-2-yl)be;1,2-Benzenediol,4-[4-(cyclopentyloxy)-2-quinolinyl]-;CMS-121/4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol;4-(4-(cyclopentyloxy)quinolin-2-yl)be nzene-1,2-diol (CMS121);ACC, Acetyl Coenzyme A Carboxylase,disease,neuroprotective,inhibit,anti-inflammatory,mitochondrial,Alzheimer's,antioxidative,acetylation,Inhibitor,H3K9,Acetyl-CoA Carboxylase,CMS 121,dementia,ACC1,CMS-121
- CBNumber:
- CB55540825
- Molecular Formula:
- C20H19NO3
- Molecular Weight:
- 321.37
- MDL Number:
- MFCD22192465
- MOL File:
- 1353224-53-9.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Boiling point | 511.0±50.0 °C(Predicted) |
|---|---|
| Density | 1.297±0.06 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMF: 30 mg/ml; DMSO: 20 mg/ml |
| form | A crystalline solid |
| pka | 8.53±0.20(Predicted) |
| color | Light yellow to yellow |
| InChI | InChI=1S/C20H19NO3/c22-18-10-9-13(11-19(18)23)17-12-20(24-14-5-1-2-6-14)15-7-3-4-8-16(15)21-17/h3-4,7-12,14,22-23H,1-2,5-6H2 |
| InChIKey | OMHNVUCFPJJLKD-UHFFFAOYSA-N |
| SMILES | C1(O)=CC=C(C2C=C(OC3CCCC3)C3C(N=2)=CC=CC=3)C=C1O |
| FDA UNII | BW9P9F8JEY |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501 |
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 27085 | CMS121 ≥98% | 1353224-53-9 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 27085 | CMS121 ≥98% | 1353224-53-9 | 5mg | $128 | 2026-04-30 | Buy |
| Cayman Chemical | 27085 | CMS121 ≥98% | 1353224-53-9 | 10mg | $236 | 2026-04-30 | Buy |
| Cayman Chemical | 27085 | CMS121 ≥98% | 1353224-53-9 | 25mg | $502 | 2026-04-30 | Buy |
| ChemScene | CS-0119097 | CMS-121 98.30% | 1353224-53-9 | 5mg | $81 | 2026-06-04 | Buy |
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Chemical Properties, Uses, Production
Uses
CMS-121 is a quinolone derivative and an orally active acetyl-CoA carboxylase 1 (ACC1) inhibitor. CMS-121 protects HT22 cells against ischemia and oxidative damage with EC50 values of 7 nM and 200 nM, respectively. CMS-121 has strong neuroprotective, anti-inflammatory, antioxidative and renoprotective activities[1][2][3].
in vivo
CMS-121 (~20 mg/kg; oral administration; daily; for 4 months; female SAMP8 mice) treatment reduces cognitive decline as well as metabolic and transcriptional markers of aging in the brain when administered to rapidly aging SAMP8 mice. CMS-121 preserves mitochondrial homeostasis by regulating acetyl-coenzyme A (acetyl-CoA) metabolism[1].
| Animal Model: | Female SAMP8 mice (9 months old)[1] |
| Dosage: | ~20 mg/kg/day |
| Administration: | Oral administration; daily; for 4 months |
| Result: | Reduced cognitive decline as well as metabolic and transcriptional markers of aging in the brain. |
References
[1] Currais A, et al. Elevating acetyl-CoA levels reduces aspects of brain aging. Elife. 2019 Nov 19;8. pii: e47866. DOI:10.7554/eLife.47866
[2] Chiruta C, et al. Chemical modification of the multitarget neuroprotective compound fisetin. J Med Chem. 2012 Jan 12;55(1):378-89. DOI:10.1021/jm2012563
[3] Prior M, et al. Back to the future with phenotypic screening. ACS Chem Neurosci. 2014 Jul 16;5(7):503-13. DOI:10.1021/cn500051h
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Preparation Products And Raw materials
Raw materials
Preparation Products
4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Sunway Pharmaceutical Technology Co., Ltd | 13761987713 | hxzheng@sunwaypharm.cn | China | 8663 | 57 |
| Suzhou Myland Nutraceuticals Inc. | 13771927830 | james@mylandpharm.com | China | 58 | 55 |
| Shanghai Synteam Biochem CO.,ltd | +86-021-58380978 13482386415 | info@systeambc.com | China | 897 | 50 |
| Shanghai Beckham Medical Technology Co., Ltd | 13816613772 | huahero21@sina.com | China | 2994 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9799 | 58 |
| Jinan Jianfeng Chemical Co., Ltd. | 0531-88110457; 18954159893 | demi@pharmachemm.com | China | 205 | 58 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 15026964105 | 2881489226@qq.com | China | 89667 | 60 |
| Henan Aosman Biotechnology Co., LTD | 13761588971 17719817155 | 2366079749@qq.com | China | 3008 | 58 |
| Shandong Fengtai Biotechnology Co., Ltd. | 0531-0531-82066716 15662658391 | 528732991@qq.com | China | 1064 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 400-920-5774 | sales@glpbio.cn | China | 6705 | 58 |
View Latest Price from 4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
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2026-09-17 | CMS-121/4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
1353224-53-9
|
1kg | 99% | 20ton | Jinan Jianfeng Chemical Co., Ltd | ||
 |
2026-08-25 | CMS-121
1353224-53-9
|
1bag | 98% | 1000 | Xi an Biohorlden Industry Trade Co Ltd | ||
 |
2026-08-25 | CMS121
1353224-53-9
|
$3.00-9.00 | 99% | ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD |
-
- CMS-121/4-(4-(cyclopentyloxy)quinolin-2-yl)benzene-1,2-diol
1353224-53-9
- $0.00
- 99%
- Jinan Jianfeng Chemical Co., Ltd
-
- CMS-121
1353224-53-9
- 98%
- Xi an Biohorlden Industry Trade Co Ltd
-
- CMS121
1353224-53-9
- $3.00-9.00
- 99%
- ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
