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IDO/TDO-IN-1

IDO/TDO-IN-1 Structure
IDO/TDO-IN-1 structure
CAS No.
2033173-01-0
Chemical Name:
IDO/TDO-IN-1
Synonyms
IDO/TDO-IN-1;IDO/TDO IN 1,IDO/TDOIN1;5H-Imidazo[5,1-a]isoindole, 6-fluoro-5-[1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-piperidinyl]-, (5S)-
CBNumber:
CB55821454
Molecular Formula:
C25H24FN5
Molecular Weight:
413.49
MDL Number:
MFCD32174301
MOL File:
2033173-01-0.mol
Last updated:2025-04-17 18:22:24
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IDO/TDO-IN-1 Properties

Boiling point 664.5±55.0 °C(Predicted)
Density 1.34±0.1 g/cm3(Predicted)
storage temp. Store at -20°C
solubility Soluble in DMSO
pka 5.63±0.40(Predicted)
form Solid
color White to off-white

IDO/TDO-IN-1 Chemical Properties,Uses,Production

Description

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1]. IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1]

IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1].

Uses

IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].

References

[1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953.

IDO/TDO-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

IDO/TDO-IN-1 Suppliers

Global( 5)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354; +17819995354 marketing@targetmol.com United States 32376 58
TargetMol Chemicals Inc. 		+1-781-999-5354; support@targetmol.com United States 38838 58
TargetMol Chemicals Inc. 		+17819995354 marketing@targetmol.com United States 19939 58
TargetMol Chemicals Inc. 15002134094 marketing@targetmol.cn China 26070 58
Adooq Bioscience LLC 400-025-6535 sales@adooq.cn China 6215 58
Supplier Advantage
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 		58
TargetMol Chemicals Inc. 58
Adooq Bioscience LLC 58

View Lastest Price from IDO/TDO-IN-1 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
IDO/TDO-IN-1 pictures 2024-10-28 IDO/TDO-IN-1
2033173-01-0
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
  • IDO/TDO-IN-1 pictures
  • IDO/TDO-IN-1
    2033173-01-0
  • US $2500.00-1520.00 / mg
  • TargetMol Chemicals Inc.
IDO/TDO-IN-1 IDO/TDO IN 1,IDO/TDOIN1 5H-Imidazo[5,1-a]isoindole, 6-fluoro-5-[1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-piperidinyl]-, (5S)- 2033173-01-0