IDO/TDO-IN-1 manufacturers
- IDO/TDO-IN-1
-
- $2500.00
-
2026-07-27
- CAS:2033173-01-0
- Purity:
- Supply Ability: 10g
- IDO/TDO-IN-1
-
- $2500.00
-
2026-07-27
- CAS:2033173-01-0
- Purity:
- Supply Ability: 10g
- IDO/TDO-IN-1
-
- $2500.00
-
2025-10-28
- CAS:2033173-01-0
- Purity:
- Supply Ability: 10g
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| | IDO/TDO-IN-1 Basic information |
| Product Name: | IDO/TDO-IN-1 | | Synonyms: | IDO/TDO-IN-1;IDO/TDO IN 1,IDO/TDOIN1;5H-Imidazo[5,1-a]isoindole, 6-fluoro-5-[1-[4-(1-methyl-1H-pyrazol-4-yl)phenyl]-4-piperidinyl]-, (5S)- | | CAS: | 2033173-01-0 | | MF: | C25H24FN5 | | MW: | 413.49 | | EINECS: | | | Product Categories: | | | Mol File: | 2033173-01-0.mol |  |
| | IDO/TDO-IN-1 Chemical Properties |
| Boiling point | 664.5±55.0 °C(Predicted) | | density | 1.34±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 5.63±0.40(Predicted) | | form | Solid | | color | White to off-white |
| | IDO/TDO-IN-1 Usage And Synthesis |
| Description | IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1].
IC50: 9.7 nM (Indoleamine-2,3-dioxygenase), 47 nM (Tryptophan 2,3-dioxygenase)[1] IDO/TDO-IN-1 inhibits IDO in the Hela cell line with an IC50 of 76 nM[1]. | | Uses | IDO/TDO-IN-1 (compound 25) is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively [1]. | | References | [1]. Tu W, et al. Discovery of Imidazoisoindole Derivatives as Highly Potent and Orally Active Indoleamine-2,3-dioxygenase Inhibitors. ACS Med Chem Lett. 2019 Jun 3;10(6):949-953. |
| | IDO/TDO-IN-1 Preparation Products And Raw materials |
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