ICI-118,551
- CAS No.
- 72795-19-8
- Chemical Name:
- ICI-118,551
- Synonyms
- Ici 111,581;ICI-118,551;ICI118551HCl;ICI 118,551 HYDROCHLORIDE;ICI 118551 Hydrochloride ((±ICI-118-551 HYDROCHLORIDE HIGHLY SELECTI VE B2 A;Erythro-DL-1-(7-methylindan-4-yloxy)-3-isopropylaminobutan-2-ol;erythro-DL-1-(7-Methylindan-4-yloxy)-3-isopropylamino-2-butanol;(2R,3S)-rel-1-[(2,3-Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol;2-Butanol, 1-((2,3-dihydro-7-methyl-1H-inden-4-yl)oxy)-3-((1-methylethyl)amino)-, (2R,3S)-rel-
- CBNumber:
- CB5676244
- Molecular Formula:
- C17H27NO2
- Molecular Weight:
- 277.4
- MDL Number:
- MFCD01074480
- MOL File:
- 72795-19-8.mol
| Melting point | 217-219°C |
|---|---|
| Boiling point | 439.3±45.0 °C(Predicted) |
| Density | 1.045±0.06 g/cm3(Predicted) |
| storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere |
| solubility | ethanol: 7.3 mg/mL |
| form | powder |
| pka | 13.87±0.20(Predicted) |
| color | white |
| InChI | 1S/C17H27NO2/c1-11(2)18-13(4)16(19)10-20-17-9-8-12(3)14-6-5-7-15(14)17/h8-9,11,13,16,18-19H,5-7,10H2,1-4H3/t13-,16-/m0/s1 |
| InChIKey | VFIDUCMKNJIJTO-BBRMVZONSA-N |
| SMILES | N([C@H]([C@@H](O)COc1c2c(c(cc1)C)CCC2)C)C(C)C |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
ICI-118,551 price More Price(12)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.05275 | ICI 118551 Hydrochloride - CAS 72795-19-8 - Calbiochem | 72795-19-8 | 10mg | $292 | 2026-04-30 | Buy |
| Usbiological | 217446 | ICI 118551 Hydrochloride ((±)-1-[2,3-(Dihydro-7-methyl-1H-inden-4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol Hydrochloride) ≥98%(HPLC) | 72795-19-8 | 10mg | $665 | 2026-06-03 | Buy |
| Biosynth | XCA79519 | Ici 118551 hydrochloride | 72795-19-8 | 1mg | $900 | 2026-06-05 | Buy |
| Biosynth | XCA79519 | Ici 118551 hydrochloride | 72795-19-8 | 10mg | $900 | 2026-06-05 | Buy |
| Biosynth | XCA79519 | Ici 118551 hydrochloride | 72795-19-8 | 5mg | $900 | 2026-06-05 | Buy |
ICI-118,551 Chemical Properties,Uses,Production
Uses
The (R,R)-enantiomer of ICI 118551 as highly selective β2-adrenoceptor antagonist. The S,S-enantiomer is the most potent.
Definition
ChEBI: ICI 118551 is an indane substituted at position 7 by a methyl group and at position 4 by a 3-(isopropylamino)-2-hydroxybutoxy group (the 2R,3S-diastereomer). It has a role as a beta-adrenergic antagonist. It is a member of indanes, an aromatic ether, a secondary alcohol and a secondary amino compound.
Biological Activity
Primary Target
-2 adrenergic receptors', 'Reversible: yes', 'Target Ki: 1.2, 120 and 257 nM for -2, -1 and -3 receptors respectively.
ICI-118,551 Preparation Products And Raw materials
Raw materials
Preparation Products
ICI-118,551 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 18930552037 | 3bsc@sina.com | China | 15813 | 69 |
| Career Henan Chemica Co | +86-0371-86658258 +86-13203830695 | laboratory@coreychem.com | China | 30203 | 58 |
| Changzhou Chenhong Biotechnology Co., Ltd. | +86-0519-85788828 +86-13775037613 | sales@chemrenpharm.com | China | 4058 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19935 | 58 |
| CONIER CHEM AND PHARMA LIMITED | sales@conier.com | China | 49906 | 58 | |
| Shanghai Botuo Biotechnology Co., LTD | 16621358918 | botuopharma888@163.com | China | 9192 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15727060112 | yutianchun2007@126.com | China | 9867 | 58 |
| Shaanxi Didu Pharmaceutical Co., Ltd. | 029-81124775 17791530730 | 1079@dideu.com | China | 10000 | 58 |
