PROTHROMBIN
- CAS No.
- 9001-26-7
- Chemical Name:
- PROTHROMBIN
- Synonyms
- FACTOR II;PROTHROMBIN;HUMAN PROTHROMBIN;PROTHROMBIN, HUMAN;PROTHROMBIN (BOVINE);PROTHROMBIN, HUMAN PLASMA;III-2isoelec.pointatpH4.2;Human Prothrombin Complex;Blood-coagulation factor II;factor ii from human plasma
- CBNumber:
- CB5681424
- Molecular Formula:
- Molecular Weight:
- 0
- MDL Number:
- MFCD00148143
- MOL File:
- Mol file
| storage temp. | −20°C |
|---|---|
| form | lyophilized powder |
| Water Solubility | water: soluble |
| FDA UNII | 8FB1K07F16 |
| UNSPSC Code | 12352202 |
| NACRES | NA.25 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319-H335 |
| Precautionary statements | P271-P280 |
| Hazard Codes | B |
| WGK Germany | 3 |
| HS Code | 3002120000 |
PROTHROMBIN price More Price(5)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 539515 | Prothrombin, Human Plasma | 9001-26-7 | 1mg | $282 | 2025-07-31 | Buy |
| Sigma-Aldrich | 539515 | Prothrombin, Human Plasma | 9001-26-7 | 2mg | $536 | 2025-07-31 | Buy |
| Usbiological | P9119A | Prothrombin | 9001-26-7 | 500ug | $529 | 2021-12-16 | Buy |
| Usbiological | P9115-16 | Prothrombin | 9001-26-7 | 1mg | $243 | 2021-12-16 | Buy |
| Usbiological | P9115-15 | Prothrombin, Bovine | 9001-26-7 | 1mg | $259 | 2021-12-16 | Buy |
PROTHROMBIN Chemical Properties,Uses,Production
Uses
Human Prothrombin is a glycoprotein with a molecular weight of 70 kDa and is composed of a single polypeptide chain. Prothrombin is activated by factors Va, Xa, and phospholipids to produce the serine protease thrombin[1].
Definition
The precursor of the enzyme thrombin, a proteinaceous component of blood plasma that is converted into thrombin by the blood- clotting mechanism when activated at the site of an open wound.
Purification Methods
Prothrombin is purified by two absorptions on a barium citrate adsorbent, followed by decomposition of the adsorbents with a weak carboxylic cation-exchanger (Amberlite IRF-97), isoelectric precipitation (pH 4.7-4.9) and further purification by chromatography on Sephadex G-200 or IRC-50. Finally it is recrystallised from a 1% solution adjusted to pH 6.0-7.0 and partial lyophilisation to ca 1/5 to 1/10th volume and set aside at 2-5o to crystallise. Occasionally seeding is required. [Miller Biochemical Preparations 13 49 1971.]
References
[1] Suttie JW, et al. Prothrombin structure, activation, and biosynthesis. Physiol Rev. 1977 Jan;57(1):1-70. DOI:10.1152/physrev.1977.57.1.1
PROTHROMBIN Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Creative Enzymes | 1-516-855-7709 | info@creative-enzymes.com | United States | 8748 | 58 |
| Shaanxi DIDU pharmaceutical and Chemical Co., Ltd | 029-029-029-81148696 18161915376 | 1040@dideu.com | China | 9818 | 58 |
| Merck Millipore | 1-400-889-1988 400-889-1988 | bioscience@merckgroup.com | China | 6839 | 58 |
| Merck KGaA | 21-20338288 | ordercn@merckgroup.com | China | 6394 | 58 |
| Enzyme Research Laboratories | 800-729527 | info@enzymeresearch.com | China | 175 | 58 |
| ProSpec Tany TechnoGene Ltd | 972-8947-1175 | info@prospecbio.com | China | 6874 | 58 |
| United States Biological | -- | sales@advtechind.com | United States | 6075 | 58 |
| Guangzhou Biopark Technology Co., Ltd. | 020-83808789 | CHINA | 179 | 58 | |
| Shijiazhuang Shouwang Technology Co., Ltd. | 13911868362 | CHINA | 116 | 58 |
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