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Tanshinone IIA

Tanshinone IIA Structure
Tanshinone IIA structure
CAS No.
568-72-9
Chemical Name:
Tanshinone IIA
Synonyms
TANSHINONE ⅡA;Tanshinone B;Tanshinone 2A;tanshiones;SweetOrange;Tanshine II;ANSHINONE ⅡA;TanshinoneⅡA;Tanshionesiia;TANSHINONE A
CBNumber:
CB5705548
Molecular Formula:
C19H18O3
Molecular Weight:
294.34
MDL Number:
MFCD00238692
MOL File:
568-72-9.mol
MSDS File:
SDS
TDS File:
TDS
Last updated:2026-09-12 14:11:26
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Tanshinone IIA Properties

Melting point 196.0 to 200.0 °C
Boiling point 480.7±44.0 °C(Predicted)
Density 1.209±0.06 g/cm3(Predicted)
storage temp. 2-8°C
solubility methanol: soluble5mg/mL, clear, red-orange to red
form powder, red
color Orange
Henry's Law Constant 2.0×103 mol/(m3Pa) at 25℃, HSDB (2015)
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Major Application food and beverages
InChI InChI=1S/C19H18O3/c1-10-9-22-18-12-6-7-13-11(5-4-8-19(13,2)3)15(12)17(21)16(20)14(10)18/h6-7,9H,4-5,8H2,1-3H3
InChIKey HYXITZLLTYIPOF-UHFFFAOYSA-N
SMILES O1C=C(C)C2C(=O)C(=O)C3=C(C1=2)C=CC1=C3CCCC1(C)C
LogP 4.925 (est)
CAS DataBase Reference 568-72-9(CAS DataBase Reference)
FDA UNII 4GPC9FQG6L
UNSPSC Code 85151701
NACRES NA.25

SAFETY

Risk and Safety Statements

Safety Statements  24/25
WGK Germany  3
RTECS  SF8282695
HS Code  29321900
Storage Class 13 - Non Combustible Solids
Hazardous Substances Data 568-72-9(Hazardous Substances Data)

Tanshinone IIA price More Price(108)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0001560 Tanshinone IIA European Pharmacopoeia (EP) Reference Standard 568-72-9 15 mg $175 2026-04-30 Buy
Sigma-Aldrich PHL89320 Tanshinone IIA phyproof? Reference Substance 568-72-9 10MG $217 2026-04-30 Buy
Sigma-Aldrich 1643339 Tanshinone IIA United States Pharmacopeia (USP) Reference Standard 568-72-9 20mg $282 2026-04-30 Buy
Sigma-Aldrich 51704 Tanshinone IIA analytical standard 568-72-9 10mg $173 2022-05-15 Buy
TCI Chemical T2987 Tanshinone IIA >97.0%(HPLC) 568-72-9 10mg $111 2026-04-30 Buy
Product number Packaging Price Buy
Y0001560 15 mg $175 Buy
PHL89320 10MG $217 Buy
1643339 20mg $282 Buy
51704 10mg $173 Buy
T2987 10mg $111 Buy

Tanshinone IIA Chemical Properties, Uses, Production

Description

Tanshinone IIA mainly exists in the roots of Salvia miltiorrhiza Bge. Traditional Chinese medicine Danshen, slightly cold and bitter, is often used for activating blood circulation and eliminating stasis in Chinese medicine. It can also promote blood circulation, open the energy channels, calm the heart, cool the blood, relieve swelling, remove twinge in the heart and stomach, and remove carbuncle and erysipelas. It is classified as high grade in Shen Nong’s Herbal Classic. It has been used as a traditional Chinese medicine in clinical practice for thousands of years. And it is not only recorded in the leading medical works through the ages but also in CP and USP.

Description

Tanshinone IIA (TSA) is a major lipophilic component of extracts from the root of S. miltiorrhiza, used widely in Chinese herbal medicine. It has anti-inflammatory activity, inhibiting production of TNF-α, IL-1β, IL-6, NO, INFγ, and expression of iNOS, and IL-12. It blocks human aortic smooth muscle cell migration, inhibits MMP-9 activity, and interferes with PI3K/Akt and ERK1/2 signaling pathways. It is cytotoxic to various cancer cells including A549 lung cancer cells and leukemia cells.Reduction of TSA by NAD(P)H:quinone oxidoreductase (NQO1) generates an unstable intermediate resulting in reactive oxygenase species-mediated apoptotic cell death.

Chemical Properties

Orange powder

Physical properties

Appearance: brick-red crystalline powder. Melting point: 209–210°C. Solubility: absorbs moisture easily, very soluble in hot water, slightly soluble in methanol or ethanol, and practically insoluble in chloroform

History

The study of the chemical composition of Salvia miltiorrhiza began in the 1930s. Japanese scholars first extracted three kinds of liposoluble components from Danshen. They are tanshinones I, II, and III.

Uses

antineoplastic, bone resorption inhibitor, antiproliferative, apoptosis inducer

Uses

Tanshinone IIA is a derivative of Tanshinone and acts as a potential inhibitor of tumor growth in vivo. Also maintains vasodilating activity in vivo.

Definition

ChEBI: 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione is an abietane diterpenoid.

Synthesis Reference(s)

Journal of the American Chemical Society, 111, p. 1522, 1989 DOI: 10.1021/ja00186a070

Biochem/physiol Actions

Phenanthrenequinone constituent of Chinese medicinal herb Danshen (Salvia miltiorrhiza). Anti-inflammatory. Antioxidant. Cytotoxic against a variety of cell lines, inlcuding human glioma cells.

Pharmacology

Long-term researches show that tanshinone exhibits a variety of pharmacological effects, such as the protection of the cardiovascular system, anti-infective effects, and antioxidant effects. As for the domestic pharmacological study of tanshinone IIA, it was first started in the Shanghai Institute of Chinese Medicine. Professor Ding Guangsheng discussed the cardiovascular effects of tanshinone IIA.He found that intraperitoneal injection of tanshinone IIA sodium sulfonate (200mg/kg) significantly prolonged the survival time of mice under hypoxia atmosphere, and an increase in cardiac output was observed in a dog under anesthesia with a one-time intravenous injection of 20 mg/kg . In recent years, the mechanism of tanshinone IIA is increasingly brought to further research. Tanshinone IIA can increase the activity of superoxide dismutase (SOD) and interfere with the pathological process of many diseases, especially in cardiovascular diseases. It can attenuate the damages from the reactive oxygen species to vascular endothelial cells, lower the risk of atherosclerosis, and reduce the formation of atheromatous plaque. tumor cells and the expression of various genes connected with the proliferation, differentiation, and apoptosis of tumor cells. It may also have something to do with the inhibition of telomerase activity in tumor cells, changes in antigen expression on tumor cell surface, etc.

Clinical Use

Tanshinone IIA is a diterpenoid quinone liposoluble ingredient of high content, and its chemical structure is the most representative in Danshen. In addition to tanshinone IIA sodium sulfonate, there are a variety of preparations of Salvia common ketone used clinically, such as tanshinone tablets, tanshinone capsules, tanshinone injection, Danshen Shuxin capsule, compound Danshen soft capsules, and compound Danshen particles.

Cytotoxicity

IC50 (μg/mL): 0.59 (A549), 0.81 (TOV-21G) and 1.9 (MIAPaCa-2), NS (MV-3)(Chang et al. 2013; Fronza et al. 2011).
IC50 (μg/mL): 2.97 (HeLa), 2.71 (KB-3-1),>2.94 (NCI-H460), 2.62 (PC3), 2.94(MCF-7), 1.62 (K562)(Wu et al. 2014)

References

[1] BOK YUN KANG . Inhibition of interleukin-12 and interferon-γ production in immune cells by tanshinones from Salvia miltiorrhiza[J]. Immunopharmacology, 2000, 49 3: Pages 355-361. DOI:10.1016/s0162-3109(00)00256-3
[2] HYUN JEA SUNG. Tanshinone IIA, an ingredient of Salvia miltiorrhiza BUNGE, induces apoptosis in human leukemia cell lines through the activation of caspase-3[J]. Experimental and Molecular Medicine, 1999, 31 4: 174-178. DOI:10.1038/emm.1999.28
[3] Suppression of AP-1 Activity by Tanshinone and Cancer Cell Growth Inhibition

Tanshinone IIA Preparation Products And Raw materials

Raw materials

Preparation Products

Tanshinone IIA Suppliers

Global Suppliers ( 606)
Supplier Tel Email Country ProdList Advantage
Hubei Weideli Chemical Reagent Co., Ltd. 027-83984790 17720532645 t17720532645@163.com China 963 58
ShangHai YuanYe Biotechnology Co., Ltd. 15026964105 shyysw007@163.com China 4998 60
Nanjing Digger Medical Technology Co. Ltd. 025-025-51191215 18013836722 2399235533@qq.com China 4932 58
Xi'an Kono chem co., Ltd. 029-84385017-8006 15891391030 info@konochemical.com China 642 58
Shaanxi Haochen Biotechnology Co., Ltd 18710685966 18710685966 511325867@qq.com China 319 58
Xi 'an Xinmengchen Biotechnology Co., LTD 15002922985 511325867@qq.com China 305 58
J & K SCIENTIFIC LTD. 18210857532 18210857532 jkinfo@jkchemical.com China 96815 76
future industrial shanghai co., ltd 400-0066400 13621662912 sales@jonln.com China 1989 65
Chembest Research Laboratories Limited 021-20908456 sales@BioChemBest.com China 5996 61
TCI (Shanghai) Development Co., Ltd. 021-67121386 Sales-CN@TCIchemicals.com China 24512 81
Supplier Advantage
Hubei Weideli Chemical Reagent Co., Ltd. 58
ShangHai YuanYe Biotechnology Co., Ltd. 60
Nanjing Digger Medical Technology Co. Ltd. 58
Xi'an Kono chem co., Ltd. 58
Shaanxi Haochen Biotechnology Co., Ltd 58
Xi 'an Xinmengchen Biotechnology Co., LTD 58
J & K SCIENTIFIC LTD. 76
future industrial shanghai co., ltd 65
Chembest Research Laboratories Limited 61
TCI (Shanghai) Development Co., Ltd. 81

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View Latest Price from Tanshinone IIA manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Tanshinone IIA pictures 2026-09-17 Tanshinone IIA
568-72-9
 1KG 98%min 30tons/month WUHAN FORTUNA CHEMICAL CO., LTD
Tanshinone IIA pictures 2026-09-11 Tanshinone IIA
568-72-9
 1G ≥98% HPLC 100KG Changsha Staherb Natural Ingredients Co., Ltd.
Tanshinone IIA pictures 2026-07-27 Tanshinone IIA
568-72-9
 $50.00 99.04% 10g TargetMol Chemicals Inc.
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    568-72-9
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Tanshinone IIA Spectrum

Tanshinone IIA(568-72-9)MSTanshinone IIA(568-72-9)1HNMRTanshinone IIA(568-72-9)IR1Tanshinone IIA(568-72-9)IR2

568-72-9 (Tanshinone IIA) Related Search:

Matrine D-(-)-Salicin Tanshinone I Icariin TanshinoneIIA
TanshinoneIIB Salvia Root P.E Tanshinone IIA 20% Sodium Tanshinone IIA 2-Furan-2-yl-benzaldehyde trimethylcumene
Ethanone, 1-(3-furanyl)- (9CI) 3-Acetyl-2,4-dimethylfuran 2,5-Dimethylphenylacetone 1-(5,6,7,8-Tetrahydro-naphthalen-1-yl)-ethanone 1,5-Dimethyl-1,2,3,4-tetrahydronaphthalene
2-(2,5-Dimethylphenyl)acetaldehyde Tanshinone IIA DANSHEN TANSHINONE STANDARDS KIT 5MG

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AKOS NCG1-0066 3,8,8-TRIMETHYL-8,9,10,11-TETRAHYDROPHENANTHRO[1,2-B]FURAN-1,2-DIONE TANSHINONE IIA 98+% Tanshinone IIA, 97%, from Salvia miltiorrhiza Bunge 1,6,6-TRIMETHYL-6,7,8,9-TETRAHYDRO-PHENANTHRO[1,2-B]FURAN-10,11-DIONE TANSHINONE IIA TANSHINONES IIA tanshiones Tanshionesiia TANSHINONE IIA 98% TANSHINONE IIA 98+% HPLC TANSHION P.E 20% SweetOrange TANSHINONE A Tanshinone 2A 1,6,6-trimethyl-2,7,8,9-tetrahydro-1H-naphtho[1,2-g]benzofuran-10,11-dione 1,6,6-trimethyl-8,9-dihydro-7H-naphtho[1,2-g]benzofuran-10,11-dione TANSHINONE IIA(P) Salvia quinone A Phenanthro[1,2-b]furan-10,11-dione,6,7,8,9- tetrahydro-1,6,6-trimethyl- 6,7,8,9-Tetrahydro-1,6,6-trimethylphenanthro[1,2-b]furan-10,11-dione Dan Shen ketone Sodium Tanshinone IIA Silate Tanshine II Stone lotus leaf extract Tanshinone II A (Salvia quinone A) Tanshinone IIA (Tanshinone B) Phenanthro [1, 2-b]furan-10, 11-dione, 6, 7, 8, 9-tetrahydro-1, 6, 6-triMethy Tanshinone ⅡA, froM Salvia Miltiorrhiza Tanshinone IIA (20 mg) ANSHINONE ⅡA Tanshinonel IIA Tanshinone IIA 568-72-9 Tanshinone IIA, 97%, from Salvia miltiorrhiza Tanshinone IIa CRS 2A tanshinone Tanshinone IIA (Dan Shen ketone) ATanshinoneⅡA Tanshinone IIA (1643339) Tanshinone IIA (7CI) Tanshinone IIA-RM Abametapir Impurity 26 Salvia Miltiorrhiza Extract, Danshen Root Extract Tanshinone IIA Tanshinonum ⅡA TanshinoneⅡA Tanshinone IIA Reference Standard Tanshinone IIA (Standard) Tanshinone B TANSHINONE ⅡA 568-72-9 8568-72-9 C19H18O3 Inhibitors chemical reagent pharmaceutical intermediate phytochemical reference standards from Chinese medicinal herbs (TCM).